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http://hdl.handle.net/1942/3269
Title: | Risks of multiple sclerosis in relatives of patients in Flanders, Belgium | Authors: | Carton, H Vlietinck, R Debruyne, J DeKeyser, J DHooghe, MB Loos, R MEDAER, Rob Truyen, L Yee, IML Sadovnick, AD |
Issue Date: | 1997 | Publisher: | BRITISH MED JOURNAL PUBL GROUP | Source: | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 62(4). p. 329-333 | Abstract: | Objectives - To calculate age adjusted risks for multiple sclerosis in relatives of Flemish patients with multiple sclerosis. Methods - Lifetime risks were calculated using the maximum likelihood approach. Results - Vital information was obtained on 674 probands with multiple sclerosis in Flanders and a total of their 26 225 first, second, and third degree relatives. Full medical information to allow documentation of multiple sclerosis status was available for 21 351 (81.4%) relatives. The age adjusted risk for parents was 1.61 (SEM 0.35)%, for siblings 2.10 (SE 0.36)%, and for children 1.71 (SEM 0.70)%. For aunts and uncles, the risk was 0.66 (SEM 0.13)%. Conclusions - The risk for first degree relatives of patients with multiple sclerosis in Flanders is increased 10-fold to 12-fold; for second degree relatives, it is increased threefold. This information can be used for risk counselling in families and provides additional support for the role of more than one locus contributing to the susceptibility of multiple sclerosis. | Notes: | CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM. STATE UNIV GHENT HOSP,DEPT NEUROL,B-9000 GHENT,BELGIUM. FREE UNIV BRUSSELS,DEPT NEUROL,BRUSSELS,BELGIUM. UNIV ANTWERP HOSP,DEPT NEUROL,ANTWERP,BELGIUM. MS CTR MELSBROEK,MELSBROEK,BELGIUM. DWI,DIEPENBEEK,BELGIUM. UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V5Z 1M9,CANADA. | Keywords: | multiple sclerosis; familial multiple sclerosis; recurrence risk | Document URI: | http://hdl.handle.net/1942/3269 | Link to publication/dataset: | http://jnnp.bmj.com/cgi/content/abstract/62/4/329 | ISI #: | A1997WR27900004 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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