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http://hdl.handle.net/1942/32690
Title: | HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery | Authors: | HENDRIX, Sven SANCHEZ, Selien Ventriglia, Elissia LEMMENS, Stefanie |
Issue Date: | 2020 | Publisher: | MDPI | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (12) (Art N° 4539) | Abstract: | Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known to reduce anti-inflammatory mediators produced by macrophages (M phi). We hypothesized that HDAC8 inhibition improves functional recovery after SCI by reducing pro-inflammatory classically activated M phi. Specific HDAC8 inhibition with PCI-34051 reduced the numbers of perilesional M phi as measured by histological analyses, but did not improve functional recovery (Basso Mouse Scale). We could not reproduce the published improvement of functional recovery described in contusion SCI models using VPA in our T-cut hemisection SCI model. The presence of spared fibers might be the underlying reason for the conflicting data in different SCI models. | Notes: | Hendrix, S (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol, B-3590 Diepenbeek, Belgium. sven.hendrix@uhasselt.be; seliensanchez@hotmail.com; elissia.ventriglia@hotmail.com; stefanie.lemmens@uhasselt.be |
Other: | Hendrix, S (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol, B-3590 Diepenbeek, Belgium. sven.hendrix@uhasselt.be; seliensanchez@hotmail.com; elissia.ventriglia@hotmail.com; stefanie.lemmens@uhasselt.be | Keywords: | HDAC inhibition;PCI-34051;valproic acid | Document URI: | http://hdl.handle.net/1942/32690 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms21124539 | ISI #: | WOS:000550163100001 | Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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ijms-21-04539-v2.pdf | Published version | 1.73 MB | Adobe PDF | View/Open |
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