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http://hdl.handle.net/1942/32767
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DC Field | Value | Language |
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dc.contributor.author | Monteiro, Thiago Santos | - |
dc.contributor.author | Adab, Hamed Zivari | - |
dc.contributor.author | Chalavi, Sima | - |
dc.contributor.author | Gooijers, Jolien | - |
dc.contributor.author | King, Brad (Bradley) Ross | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | Mantini, Dante | - |
dc.contributor.author | Swinnen, Stephan Patrick | - |
dc.date.accessioned | 2020-12-02T09:44:43Z | - |
dc.date.available | 2020-12-02T09:44:43Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-11-12T12:52:25Z | - |
dc.identifier.citation | CEREBRAL CORTEX, 30 (8) , p. 4346 -4360 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32767 | - |
dc.description.abstract | Aging is accompanied by marked changes in motor behavior and its neural correlates. At the behavioral level, age-related declines in motor performance manifest, for example, as a reduced capacity to inhibit interference between hands during bimanual movements, particularly when task complexity increases. At the neural level, aging is associated with reduced differentiation between distinct functional systems. Functional connectivity (FC) dedifferentiation is characterized by more homogeneous connectivity patterns across various tasks or task conditions, reflecting a reduced ability of the aging adult to modulate brain activity according to changing task demands. It is currently unknown, however, how whole-brain dedifferentiation interacts with increasing task complexity. In the present study, we investigated age- and task-related FC in a group of 96 human adults across a wide age range (19.9-74.5 years of age) during the performance of a bimanual coordination task of varying complexity. Our findings indicated stronger task complexity-related differentiation between visuomotor- and nonvisuomotor-related networks, though modulation capability decreased with increasing age. Decreased FC modulation mediated larger complexity-related increases in between-hand interference, reflective of worse bimanual coordination. Thus, the ability to maintain high motor performance levels in older adults is related to the capability to properly segregate and modulate functional networks. | - |
dc.description.sponsorship | Research Foundation Flanders (G089818 N); Excellence of Science grant (EOS, 30446199, MEMODYN); KU Leuven Research Fund (C16/15/070). | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.rights | 2020 Oxford University Press. | - |
dc.subject.other | aging | - |
dc.subject.other | bimanual coordination | - |
dc.subject.other | functional connectivity | - |
dc.title | Reduced Modulation of Task-Related Connectivity Mediates Age-Related Declines in Bimanual Performance | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4360 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 4346 | - |
dc.identifier.volume | 30 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Monteiro, TS (corresponding author), Res Ctr Movement Control & Neuroplast, Grp Biomed Sci, Tervuursevest 101 Box 1501, B-3001 Leuven, Belgium. | - |
dc.description.notes | thiago.santosmonteiro@kuleuven.be | - |
dc.description.other | Monteiro, TS (corresponding author), Res Ctr Movement Control & Neuroplast, Grp Biomed Sci, Tervuursevest 101 Box 1501, B-3001 Leuven, Belgium. thiago.santosmonteiro@kuleuven.be | - |
local.publisher.place | JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/cercor/bhaa021 | - |
dc.identifier.pmid | 32133505 | - |
dc.identifier.isi | WOS:000562454500006 | - |
dc.contributor.orcid | Gooijers, Jolien/0000-0002-7569-7223; King, Bradley/0000-0002-3010-8755; | - |
dc.contributor.orcid | Santos Monteiro, Thiago/0000-0002-3656-9747 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Monteiro, Thiago Santos; Adab, Hamed Zivari; Chalavi, Sima; Gooijers, Jolien; King, Brad (Bradley) Ross; Cuypers, Koen; Mantini, Dante; Swinnen, Stephan Patrick] Katholieke Univ Leuven, Dept Movement Sci, Res Ctr Movement Control & Neuroplast, Biomed Sci Grp, Leuven, Belgium. | - |
local.description.affiliation | [Monteiro, Thiago Santos; Adab, Hamed Zivari; Chalavi, Sima; Gooijers, Jolien; King, Brad (Bradley) Ross; Cuypers, Koen; Mantini, Dante; Swinnen, Stephan Patrick] Katholieke Univ Leuven, Leuven Brain Inst LBI, Leuven, Belgium. | - |
local.description.affiliation | [Cuypers, Koen] Hasselt Univ, REVAL Res Inst, Diepenbeek, Belgium. | - |
local.description.affiliation | [Mantini, Dante] IRCCS San Camillo Hosp, Brain Imaging & Neural Dynam Res Grp, Venice, Italy. | - |
item.fullcitation | Monteiro, Thiago Santos; Adab, Hamed Zivari; Chalavi, Sima; Gooijers, Jolien; King, Brad (Bradley) Ross; CUYPERS, Koen; Mantini, Dante & Swinnen, Stephan Patrick (2020) Reduced Modulation of Task-Related Connectivity Mediates Age-Related Declines in Bimanual Performance. In: CEREBRAL CORTEX, 30 (8) , p. 4346 -4360. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | Monteiro, Thiago Santos | - |
item.contributor | Adab, Hamed Zivari | - |
item.contributor | Chalavi, Sima | - |
item.contributor | Gooijers, Jolien | - |
item.contributor | King, Brad (Bradley) Ross | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | Mantini, Dante | - |
item.contributor | Swinnen, Stephan Patrick | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1047-3211 | - |
crisitem.journal.eissn | 1460-2199 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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bhaa021.pdf | Published version | 1.67 MB | Adobe PDF | View/Open |
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