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http://hdl.handle.net/1942/32798
Title: | Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset | Authors: | BORREMANS, Benny Gamble, Amandine Prager, K. C. Helman, Sarah K. McClain, Abby M. Cox, Caitlin Savage, Van Lloyd-Smith, James O. |
Issue Date: | 2020 | Publisher: | ELIFE SCIENCES PUBLICATIONS LTD | Source: | ELIFE, 9 (Art N° e60122) | Abstract: | Understanding and mitigating SARS-CoV-2 transmission hinges on antibody and viral RNA data that inform exposure and shedding, but extensive variation in assays, study group demographics and laboratory protocols across published studies confounds inference of true biological patterns. Our meta-analysis leverages 3214 datapoints from 516 individuals in 21 studies to reveal that seroconversion of both IgG and IgM occurs around 12 days post-symptom onset (range 1-40), with extensive individual variation that is not significantly associated with disease severity. IgG and IgM detection probabilities increase from roughly 10% at symptom onset to 98-100% by day 22, after which IgM wanes while IgG remains reliably detectable. RNA detection probability decreases from roughly 90% to zero by day 30, and is highest in feces and lower respiratory tract samples. Our findings provide a coherent evidence base for interpreting clinical diagnostics, and for the mathematical models and serological surveys that underpin public health policies. | Notes: | Borremans, B (corresponding author), Univ Calif Los Angeles, Ecol & Evolutionary Biol Dept, Los Angeles, CA 90095 USA.; Borremans, B (corresponding author), Hasselt Univ, Data Sci Inst, I BioStat, Hasselt, Belgium.; Borremans, B (corresponding author), Univ Antwerp, Evolutionary Ecol Grp, Antwerp, Belgium. bennyborremans@gmail.com |
Other: | Borremans, B (correspondin, g author), Univ Calif Los Angeles, Ecol & Evolutionary Biol Dept, Los Angeles, CA 90095 USA ; Hasselt Univ, Data Sci Inst, I BioStat, Hasselt, Belgium ; Univ Antwerp, Evolutionary Ecol Grp, Antwerp, Belgium. bennyborremans@gmail.com | Keywords: | Viral Load;Coronavirus;Responses | Document URI: | http://hdl.handle.net/1942/32798 | ISSN: | 2050-084X | e-ISSN: | 2050-084X | DOI: | 10.7554/eLife.60122 | ISI #: | WOS:000575352900001 | Rights: | Copyright Borremans et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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BORREMANS_B_2020.pdf | Published version | 8.52 MB | Adobe PDF | View/Open |
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