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http://hdl.handle.net/1942/32799
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DC Field | Value | Language |
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dc.contributor.author | Reijniers, Jonas | - |
dc.contributor.author | Tersago, Katrien | - |
dc.contributor.author | BORREMANS, Benny | - |
dc.contributor.author | Hartemink, Nienke | - |
dc.contributor.author | Voutilainen, Liina | - |
dc.contributor.author | Henttonen, Heikki | - |
dc.contributor.author | Leirs, Herwig | - |
dc.date.accessioned | 2020-12-08T08:30:59Z | - |
dc.date.available | 2020-12-08T08:30:59Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-12-01T12:58:04Z | - |
dc.identifier.citation | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10 (Art N° 536660) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32799 | - |
dc.description.abstract | For wildlife diseases, one often relies on host density to predict host infection prevalence and the subsequent force of infection to humans in the case of zoonoses. Indeed, if transmission is mainly indirect, i.e., by way of the environment, the force of infection is expected to increase with host density, yet the laborious field data supporting this theoretical claim are often absent. Hantaviruses are among those zoonoses that have been studied extensively over the past decades, as they pose a significant threat to humans. In Europe, the most widespread hantavirus is the Puumala virus (PUUV), which is carried by the bank vole and causes nephropathia epidemica (NE) in humans. Extensive field campaigns have been carried out in Central Finland to shed light on this supposed relationship between bank vole density and PUUV prevalence and to identify other drivers for the infection dynamics. This resulted in the surprising observation that the relationship between bank vole density and PUUV prevalence is not purely monotonic on an annual basis, contrary to what previous models predicted: a higher vole density does not necessary result in a higher infection prevalence, nor in an increased number of humans reported having NE. Here, we advance a novel individual-based spatially-explicit model which takes into account the immunity provided by maternal antibodies and which simulates the spatial behavior of the host, both possible causes for this discrepancy that were not accounted for in previous models. We show that the reduced prevalence in peak years can be attributed to transient immunity, and that the density-dependent spatial vole behavior, i.e., the fact that home ranges are smaller in high density years, plays only a minor role. The applicability of the model is not limited to the study and prediction of PUUV (and NE) occurrence in Europe, as it could be easily adapted to model other rodent-borne diseases, either with indirect or direct transmission. | - |
dc.description.sponsorship | This study was funded by EU grant FP7-261504 EDENext and is cataloged by the EDENext Steering Committee as EDENext426 (http://www.edenext.eu).The contents of this publication are the sole responsibility of the authors and don't necessarily reflect the views of the European Commission. This work was supported by the University of Antwerp and the Antwerp Study Center for Infectious Diseases (ASCID). | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | © 2020 Reijniers, Tersago, Borremans, Hartemink, Voutilainen, Henttonen and Leirs. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | hantavirus | - |
dc.subject.other | Puumala virus | - |
dc.subject.other | spatial behavior | - |
dc.subject.other | maternal antibodies | - |
dc.subject.other | bank vole | - |
dc.title | Why Hantavirus Prevalence Does Not Always Increase With Host Density: Modeling the Role of Host Spatial Behavior and Maternal Antibodies | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 10 | - |
local.format.pages | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Leirs, H (corresponding author), Univ Antwerp, Dept Biol, Evolutionary Ecol Grp, Antwerp, Belgium. | - |
dc.description.notes | herwig.leirs@uantwerpen.be | - |
dc.description.other | Leirs, H (corresponding author), Univ Antwerp, Dept Biol, Evolutionary Ecol Grp, Antwerp, Belgium. herwig.leirs@uantwerpen.be | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 536660 | - |
dc.identifier.doi | 10.3389/fcimb.2020.536660 | - |
dc.identifier.pmid | 33134187 | - |
dc.identifier.isi | WOS:000576865700001 | - |
dc.identifier.eissn | - | |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Reijniers, Jonas; Borremans, Benny; Leirs, Herwig] Univ Antwerp, Dept Biol, Evolutionary Ecol Grp, Antwerp, Belgium. | - |
local.description.affiliation | [Reijniers, Jonas] Univ Antwerp, Dept Engn Management, Act Percept Lab, Antwerp, Belgium. | - |
local.description.affiliation | [Tersago, Katrien] Govt Adm, Agentschap Zorg & Gezondheid, Brussels, Belgium. | - |
local.description.affiliation | [Borremans, Benny] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA. | - |
local.description.affiliation | [Borremans, Benny] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. | - |
local.description.affiliation | [Hartemink, Nienke] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Theoret Ecol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Hartemink, Nienke] Wageningen Univ & Res, Biometris, Wageningen, Netherlands. | - |
local.description.affiliation | [Voutilainen, Liina] Univ Helsinki, Dept Virol, Helsinki, Finland. | - |
local.description.affiliation | [Henttonen, Heikki] Nat Resources Inst Finland, Terr Populat Dynam, Helsinki, Finland. | - |
item.fullcitation | Reijniers, Jonas; Tersago, Katrien; BORREMANS, Benny; Hartemink, Nienke; Voutilainen, Liina; Henttonen, Heikki & Leirs, Herwig (2020) Why Hantavirus Prevalence Does Not Always Increase With Host Density: Modeling the Role of Host Spatial Behavior and Maternal Antibodies. In: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10 (Art N° 536660). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | Reijniers, Jonas | - |
item.contributor | Tersago, Katrien | - |
item.contributor | BORREMANS, Benny | - |
item.contributor | Hartemink, Nienke | - |
item.contributor | Voutilainen, Liina | - |
item.contributor | Henttonen, Heikki | - |
item.contributor | Leirs, Herwig | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2235-2988 | - |
crisitem.journal.eissn | 2235-2988 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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fcimb-10-536660.pdf | Published version | 1.67 MB | Adobe PDF | View/Open |
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