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http://hdl.handle.net/1942/32802
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DC Field | Value | Language |
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dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | GRAJCHEN, Elien | - |
dc.contributor.author | WOUTERS, Elien | - |
dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.date.accessioned | 2020-12-08T11:25:50Z | - |
dc.date.available | 2020-12-08T11:25:50Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-11-17T13:04:46Z | - |
dc.identifier.citation | THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 11 (Art N° 2040622320947378) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32802 | - |
dc.description.abstract | Background and aims: Alemtuzumab is a humanized monoclonal antibody that depletes CD52-bearing B and T lymphocytes. Clinical trials defined that systemic administration of alemtuzumab reduces disease severity in the relapsing-remitting phase of multiple sclerosis (MS). However, its efficacy in progressive MS patients is limited, which may reflect the inability of alemtuzumab to cross the reconstituted BBB in these patients. Objective: to study whether central nervous system (CNS) delivery of anti-CD52 antibodies reduces disease severity and the neuroinflammatory burden in the experimental autoimmune encephalomyelitis (EAE) model. Methods: Anti-CD52 antibodies were administered intrathecally during the acute and chronic phases of EAE. Flow cytometry and immunohistochemistry were utilized to define immunological and pathological parameters. Results: We show that subcutaneously administrated anti-CD52 antibodies completely abolish EAE disease severity. CNS delivery of anti-CD52 antibodies during both the acute and chronic phases of EAE moderately reduces disease severity and the neuroinflammatory burden. Our findings further suggest that CNS delivery of anti-CD52 antibodies impacts both the peripheral and CNS immune cell compartments in the EAE model but not in healthy mice. Conclusion: Collectively, our findings highlight the therapeutic potential of CNS delivery of alemtuzumab for the treatment of progressive as well as early MS. | - |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was funded by Sanofi Genzyme, and grants of the Belgian Charcot Foundation, Research Foundation Flanders (FWO), and European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.rights | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). | - |
dc.subject.other | alemtuzumab | - |
dc.subject.other | CD52 | - |
dc.subject.other | experimental autoimmune encephalomyelitis | - |
dc.subject.other | lymphocytes | - |
dc.subject.other | multiple sclerosis | - |
dc.subject.other | neuroinflammation | - |
dc.title | CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 11 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | Jerome.hendriks@uhasselt.be | - |
dc.description.other | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. Jerome.hendriks@uhasselt.be | - |
local.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2040622320947378 | - |
dc.identifier.doi | 10.1177/2040622320947378 | - |
dc.identifier.pmid | 32913622 | - |
dc.identifier.isi | WOS:000563499600001 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Bogie, Jeroen F. J.; Grajchen, Elien; Wouters, Elien; Broux, Bieke; Stinissen, Piet; Van Wijmeersch, Bart; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Van Wijmeersch, Bart] Rehabil & MS Ctr, Overpelt, Belgium. | - |
local.description.affiliation | [Van Wijmeersch, Bart] Hasselt Univ, Hasselt, Belgium. | - |
item.fulltext | With Fulltext | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | GRAJCHEN, Elien | - |
item.contributor | WOUTERS, Elien | - |
item.contributor | BROUX, Bieke | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | HENDRIKS, Jerome | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2021 | - |
item.fullcitation | BOGIE, Jeroen; GRAJCHEN, Elien; WOUTERS, Elien; BROUX, Bieke; STINISSEN, Piet; VAN WIJMEERSCH, Bart & HENDRIKS, Jerome (2020) CNS delivery of anti-CD52 antibodies modestly reduces disease severity in an animal model for multiple sclerosis. In: THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 11 (Art N° 2040622320947378). | - |
crisitem.journal.issn | 2040-6223 | - |
crisitem.journal.eissn | 2040-6231 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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2040622320947378.pdf | Published version | 1.53 MB | Adobe PDF | View/Open |
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