Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/32803
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dc.contributor.authorBELMANS, Niels-
dc.contributor.authorGilles, Liese-
dc.contributor.authorVermeesen, Randy-
dc.contributor.authorVirag, Piroska-
dc.contributor.authorHedesiu, Mihaela-
dc.contributor.authorSalmon, Benjamin-
dc.contributor.authorBaatout, Sarah-
dc.contributor.authorLucas, Stephane-
dc.contributor.authorLAMBRICHTS, Ivo-
dc.contributor.authorJacobs, Reinhilde-
dc.contributor.authorMOREELS, Marjan-
dc.date.accessioned2020-12-08T11:33:08Z-
dc.date.available2020-12-08T11:33:08Z-
dc.date.issued2020-
dc.date.submitted2020-11-12T12:35:23Z-
dc.identifier.citationSCIENTIFIC REPORTS, 10 (1) (Art N° 2113)-
dc.identifier.urihttp://hdl.handle.net/1942/32803-
dc.description.abstractAssessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines.-
dc.description.sponsorshipThe authors like to thank all patients (and their parents) for their willingness to contribute to this study. They also like to express their gratitude towards the hospital staff, especially Christelle Lefevre and the CRB facility (Dr. Sarah Tubiana, HUPNVS - APHP, France) for their indispensable help with the sample collection. The DIMITRA project has received funding from the European Atomic Energy Community's Seventh Framework Programme FP7/2007-2011 under grant agreement no 604984 (OPERRA: Open Project for the European Radiation Research Area). The DIMITRA Research Group that contributed to this paper consists of N. Belmans, M. Moreels, S. Baatout, B. Salmon, A.C. Oenning, C. Chaussain, C. Lefevre, M. Hedesiu, P. Virag, M. Baciut, M. Marcu, O. Almasan, R. Roman, A. Porumb, C. Dinu, H. Rotaru, C. Ratiu, O. Lucaciu, B. Crisan, S. Bran, G. Baciut, R. Jacobs, H. Bosmans, R. Bogaerts, C. Politis, A. Stratis, R. Pauwels, K. de F. Vasconcelos, L. Nicolielo, G. Zhang, E. Tijskens, M. Vranckx, A. Ockerman, E. Claerhout, E. Embrechts.-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/-
dc.subject.otherBuccal Mucosa Cells-
dc.subject.otherCone-Beam Ct-
dc.subject.otherGamma-H2ax Foci-
dc.subject.otherCancer-Risk-
dc.subject.otherComputed-Tomography-
dc.subject.otherIonizing-Radiation-
dc.subject.otherAdaptive Response-
dc.subject.otherSubsequent Risk-
dc.subject.otherNucleotide Pool-
dc.subject.otherBrain-Tumor-
dc.titleQuantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume10-
local.format.pages13-
local.bibliographicCitation.jcatA1-
dc.description.notesMoreels, M (corresponding author), SCK CEN, Belgian Nucl Res Ctr, Radiobiol Unit, Mol, Belgium.-
dc.description.notesmarjan.moreels@sckcen.be-
dc.description.otherMoreels, M (corresponding author), SCK CEN, Belgian Nucl Res Ctr, Radiobiol Unit, Mol, Belgium. marjan.moreels@sckcen.be-
local.publisher.placeMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr2113-
dc.identifier.doi10.1038/s41598-020-58746-5-
dc.identifier.pmid32034200-
dc.identifier.isiWOS:000562828900010-
dc.contributor.orcidLambrichts, Ivo/0000-0001-7520-0021; Costa Oenning, Anne-
dc.contributor.orcidCaroline/0000-0001-9731-8629; jacobs, reinhilde/0000-0002-3461-0363;-
dc.contributor.orcidSALMON, Benjamin/0000-0001-8739-2753; Lucaciu,-
dc.contributor.orcidOndine/0000-0002-0092-8955; Belmans, Niels/0000-0002-0829-060X-
dc.identifier.eissn-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Belmans, Niels; Gilles, Liese; Lambrichts, Ivo] Hasselt Univ, Morphol Grp, Biomed Res Inst, Agoralaan Bldg C, Diepenbeek, Belgium.-
local.description.affiliation[Belmans, Niels; Vermeesen, Randy; Baatout, Sarah; Moreels, Marjan] SCK CEN, Belgian Nucl Res Ctr, Radiobiol Unit, Mol, Belgium.-
local.description.affiliation[Virag, Piroska] Inst Oncol Prof Dr Ion Chiricuta, Cluj Napoca, Romania.-
local.description.affiliation[Hedesiu, Mihaela] Iuliu Hatieganu Univ Med & Pharm, Dept Oral & Maxillofacial Radiol, Cluj Napoca, Romania.-
local.description.affiliation[Salmon, Benjamin] Paris Descartes Univ, Sorbonne Paris Cite, EA 2496, Orofacial Pathol Imaging & Biotherapies Lab, Paris, France.-
local.description.affiliation[Salmon, Benjamin] Bretonneau Hosp, AP HP, HUPNVS, Dept Dent Med, Paris, France.-
local.description.affiliation[Lucas, Stephane] Univ Namur, Namur Res Inst Life Sci, Namur, Belgium.-
local.description.affiliation[Jacobs, Reinhilde] Katholieke Univ Leuven, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Kapucijnenvoer 7, Leuven, Belgium.-
local.description.affiliation[Jacobs, Reinhilde] Univ Hosp, Oral & Maxillofacial Surg, Dentomaxillofacial Imaging Ctr, Kapucijnenvoer 7, Leuven, Belgium.-
local.description.affiliation[Jacobs, Reinhilde] Karolinska Inst, Dept Dent Med, Huddinge, Sweden.-
item.validationecoom 2021-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.fullcitationBELMANS, Niels; Gilles, Liese; Vermeesen, Randy; Virag, Piroska; Hedesiu, Mihaela; Salmon, Benjamin; Baatout, Sarah; Lucas, Stephane; LAMBRICHTS, Ivo; Jacobs, Reinhilde & MOREELS, Marjan (2020) Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan. In: SCIENTIFIC REPORTS, 10 (1) (Art N° 2113).-
item.contributorBELMANS, Niels-
item.contributorGilles, Liese-
item.contributorVermeesen, Randy-
item.contributorVirag, Piroska-
item.contributorHedesiu, Mihaela-
item.contributorSalmon, Benjamin-
item.contributorBaatout, Sarah-
item.contributorLucas, Stephane-
item.contributorLAMBRICHTS, Ivo-
item.contributorJacobs, Reinhilde-
item.contributorMOREELS, Marjan-
crisitem.journal.issn2045-2322-
crisitem.journal.eissn2045-2322-
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