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http://hdl.handle.net/1942/32807
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DC Field | Value | Language |
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dc.contributor.author | Takahashi, Kuniaki | - |
dc.contributor.author | Wang, Rutao | - |
dc.contributor.author | Kawashima, Hideyuki | - |
dc.contributor.author | Tomaniak, Mariusz | - |
dc.contributor.author | Gao, Chao | - |
dc.contributor.author | Ono, Masafumi | - |
dc.contributor.author | Hara, Hironori | - |
dc.contributor.author | Wykrzykowska, Joanna J. | - |
dc.contributor.author | de Winter, Robbert J. | - |
dc.contributor.author | Werner, Nikos | - |
dc.contributor.author | Teiger, Emmanuel | - |
dc.contributor.author | Almeida, Manuel | - |
dc.contributor.author | Barraud, Pascal | - |
dc.contributor.author | Lantelme, Pierre | - |
dc.contributor.author | Barlis, Peter | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2020-12-08T14:15:22Z | - |
dc.date.available | 2020-12-08T14:15:22Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-12-08T12:56:42Z | - |
dc.identifier.citation | International journal of cardiology (print), 320 , p. 27 -34 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32807 | - |
dc.description.abstract | Backgrounds: Data on optimal antiplatelet therapy in patients undergoing stenting of the proximal left anterior descending artery (LAD) are limited. Methods: This is a post-hoc analysis of the GLOBAL LEADERS trial, a prospective, multi-center, randomized controlled trial, comparing the experimental strategy (1-month dual anti-platelet therapy [DAPT] followed by 23-month ticagrelor monotherapy) with the reference regimen (12-month DAPT followed by 12-month aspirin monotherapy) in relation to stenting of the proximal LAD. The primary endpoint was the composite of all-cause death or new Q-wave myocardial infarction (MI) and key secondary safety endpoint was Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding at two years. Results: Among 15,845 patients included in the analysis, 3823 (23.9%) patients underwent stenting of the proximal LAD, while 12,022 (75.2%) did not. In the proximal LAD stenting group, there was no significant difference in the risk of the primary endpoint between the two antiplatelet strategies (3.38% vs. 3.93%; hazard ratio [HR]:0.86; 95% CI:0.62-1.20; P-interaction = 0.951). However, the risk of any MI (2.63% vs. 3.88%; HR:0.68; 95% CI:0.47-0.97; P-interaction = 0.015) and any revascularization (7.84% vs. 9.94%; HR:0.78; 95% CI:0.63-0.97; Pinteraction = 0.058) was significantly lower in the experimental strategy group, while demonstrating a similar risk of BARC type 3 or 5 bleeding between the two antiplatelet strategies (1.93% vs. 1.99%; HR:0.98; 95% CI:0.62-1.54; P-interaction = 0.981). Conclusions: The present study showed patients having stenting to the proximal LAD could potentially benefit from the experimental strategy with lower ischaemic events without a trade-off in major bleeding at two years. (C) 2020 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | The GLOBAL LEADERS trial was supported by an unrestricted resource from AstraZeneca, Biosensors, and The Medicines Company. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject.other | Dual antiplatelet therapy | - |
dc.subject.other | Drug-eluting stent | - |
dc.subject.other | Proximal left anterior artery descending artery | - |
dc.subject.other | Ticagrelor monotherapy | - |
dc.title | Efficacy and safety of one-month DAPT followed by 23-month ticagrelor monotherapy in patients undergoing proximal LAD stenting: Insights from the GLOBAL LEADERS trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 34 | - |
dc.identifier.spage | 27 | - |
dc.identifier.volume | 320 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Serruys, PW (corresponding author), Natl Univ Ireland, Intervent Med & Innovat, Galway NUIG, Galway, Ireland. | - |
dc.description.notes | patrick.w.j.c.serruys@gmail.com | - |
dc.description.other | Serruys, PW (corresponding author), Natl Univ Ireland, Intervent Med & Innovat, Galway NUIG, Galway, Ireland. patrick.w.j.c.serruys@gmail.com | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, | - |
local.publisher.place | IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ijcard.2020.07.042 | - |
dc.identifier.isi | WOS:000580594200008 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Takahashi, Kuniaki; Kawashima, Hideyuki; Ono, Masafumi; Hara, Hironori; Wykrzykowska, Joanna J.; de Winter, Robbert J.] Univ Amsterdam, Med Ctr, Locat Acad Med Ctr, Dept Cardiol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Wang, Rutao; Gao, Chao] Radboud Univ Nijmegen, Depatment Cardiol, Nijmegen, Netherlands. | - |
local.description.affiliation | [Tomaniak, Mariusz] Erasmus Med Univ Ctr, Thorax Ctr, Dept Cardiol, Rotterdam, Netherlands. | - |
local.description.affiliation | [Werner, Nikos] Univ Hosp Bonn, Heart Ctr, Dept Med 2, Bonn, Germany. | - |
local.description.affiliation | [Teiger, Emmanuel] Univ Hosp Henri Mondor, Creteil, France. | - |
local.description.affiliation | [Almeida, Manuel] Hosp Santa Cruz, Lisbon, Portugal. | - |
local.description.affiliation | [Barraud, Pascal] Clin Domes, Clermont Ferrand, France. | - |
local.description.affiliation | [Lantelme, Pierre] Hop Croix Rousse, Lyon, France. | - |
local.description.affiliation | [Barlis, Peter] Northern Hosp, Epping, NSW, Australia. | - |
local.description.affiliation | [Barlis, Peter] St Vincents Heart Ctr, Fitzroy, Vic, Australia. | - |
local.description.affiliation | [Garg, Scot] Royal Blackburn Hosp, Blackburn, Lancs, England. | - |
local.description.affiliation | [Hamm, Christian] Univ Giessen, Kerckhoff Heartand Thorax Ctr, Bad Nauheim, Germany. | - |
local.description.affiliation | [Steg, Philippe Gabriel] Univ Paris Diderot, FACT French Alliance Cardiovasc Trials, Paris, France. | - |
local.description.affiliation | [Onuma, Yoshinobu; Serruys, Patrick W.] Natl Univ Ireland, Dept Cardiol, Galway NUIG, Galway, Ireland. | - |
local.description.affiliation | [Vranckx, Pascal] Hartctr Hasselt, Dept Cardiol & Crit Care Med, Ziekenhuis, Hasselt, Belgium. | - |
local.description.affiliation | [Vranckx, Pascal] Univ Hassell, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Windecker, Stephan; Valgimigli, Marco] Univ Bern, Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Takahashi, Kuniaki; Wang, Rutao; Kawashima, Hideyuki; Tomaniak, Mariusz; Gao, Chao; Ono, Masafumi; Hara, Hironori; Wykrzykowska, Joanna J.; de Winter, Robbert J.; Werner, Nikos; Teiger, Emmanuel; Almeida, Manuel; Barraud, Pascal; Lantelme, Pierre; Barlis, Peter; Garg, Scot; Hamm, Christian; Steg, Philippe Gabriel; Onuma, Yoshinobu; VRANCKX, Pascal; Windecker, Stephan; Valgimigli, Marco & Serruys, Patrick W. (2020) Efficacy and safety of one-month DAPT followed by 23-month ticagrelor monotherapy in patients undergoing proximal LAD stenting: Insights from the GLOBAL LEADERS trial. In: International journal of cardiology (print), 320 , p. 27 -34. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Takahashi, Kuniaki | - |
item.contributor | Wang, Rutao | - |
item.contributor | Kawashima, Hideyuki | - |
item.contributor | Tomaniak, Mariusz | - |
item.contributor | Gao, Chao | - |
item.contributor | Ono, Masafumi | - |
item.contributor | Hara, Hironori | - |
item.contributor | Wykrzykowska, Joanna J. | - |
item.contributor | de Winter, Robbert J. | - |
item.contributor | Werner, Nikos | - |
item.contributor | Teiger, Emmanuel | - |
item.contributor | Almeida, Manuel | - |
item.contributor | Barraud, Pascal | - |
item.contributor | Lantelme, Pierre | - |
item.contributor | Barlis, Peter | - |
item.contributor | Garg, Scot | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Serruys, Patrick W. | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0167-5273 | - |
crisitem.journal.eissn | 1874-1754 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0167527320335270-main.pdf Restricted Access | Published version | 1.47 MB | Adobe PDF | View/Open Request a copy |
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