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http://hdl.handle.net/1942/32847
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DC Field | Value | Language |
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dc.contributor.author | KOC, Ozgur | - |
dc.contributor.author | Kuypers, Dirk | - |
dc.contributor.author | Dupont, Lieven J. | - |
dc.contributor.author | Vos, Robin | - |
dc.contributor.author | Van Keer, Jan M. | - |
dc.contributor.author | Van Cleemput, Johan | - |
dc.contributor.author | ROBAEYS, Geert | - |
dc.contributor.author | Oude Lashof, Astrid | - |
dc.contributor.author | Kramer, Matthijs | - |
dc.contributor.author | Verleden, Geert | - |
dc.contributor.author | Verbeek, Jef | - |
dc.contributor.author | Nevens, Frederik | - |
dc.date.accessioned | 2020-12-09T15:13:28Z | - |
dc.date.available | 2020-12-09T15:13:28Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2020-12-01T13:40:28Z | - |
dc.identifier.citation | Journal of viral hepatitis, 28 (1), p. 105-111 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32847 | - |
dc.description.abstract | Background Hepatitis B virus (HBV) immunity is recommended to optimize outcomes after solid organ transplantation (SOT). This study assessed the prevalence and predictors of HBV immunity at the time patients were placed on transplant waiting list over a period from 1997 to 2019 in a low HBV endemic region. Methods Data were obtained from the University Hospitals Leuven transplant database. Minors and patients with past/current HBV infection were excluded. From 1986, Belgian patients are covered by the universal infant vaccination; therefore, birth cohort was stratified in those born >= 1986 vs The study population consisted of 3297 SOT candidates. HBV immunity rate was superior in renal transplant candidates (55.3%), and this number was 21.5%, 15.4% and 16.8% for liver, cardiac and pulmonary transplant candidates, respectively,P < .001. Among liver transplant candidates, HBV immunity rate was 14.8% in decompensated cirrhotic patients and 27.9% in those without advanced cirrhosis (P < .001). The overall immunity rate increased from 19.3% in period 1997-2008 to 32.8% in 2009-2019,P < .001. In multivariable analyses, younger age (odds ratio (OR) 95% confidence interval (CI): 0.97-0.98,P < .001) and birth cohort >= 1986 (OR 95% CI: 1.18-2.66,P = .006) were associated with increased HBV immunity. Conclusion An increase in HBV immunity was observed over a 20-year period related to the introduction of universal infant HBV vaccination. Nevertheless, this study highlights the low overall HBV immunity at the time of listing for organ transplantation and points out the need of an increased awareness and vaccination strategy at an early disease stage. | - |
dc.description.sponsorship | This research is part of the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Jessa Hospital and Ziekenhuis Oost-Limburg. The authors specially thank Bruno Desschans and Albert Herelixka for the management of the transplant database. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2020 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.subject.other | Abbreviations: BMI, body mass index | - |
dc.subject.other | CI, confidence interval | - |
dc.subject.other | HBsAg, hepatitis B surface antigen | - |
dc.subject.other | HBV, hepatitis B virus | - |
dc.subject.other | HCV, hepatitis C virus | - |
dc.subject.other | HLA, human leucocyte antigen | - |
dc.subject.other | OR, odds ratio | - |
dc.subject.other | SOT, solid organ transplant | - |
dc.title | The effect of universal infant vaccination on the prevalence of hepatitis B immunity in adult solid organ transplant candidates | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 111 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 105 | - |
dc.identifier.volume | 28 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
dc.description.notes | ozgur.koc@uhasselt.be | - |
dc.description.other | Koc, OM (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. ozgur.koc@uhasselt.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/jvh.13414 | - |
dc.identifier.pmid | 32989861 | - |
dc.identifier.isi | WOS:000577707400001 | - |
dc.contributor.orcid | Verbeek, Jef/0000-0002-1549-8003 | - |
dc.identifier.eissn | 1365-2893 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Koc, Ozgur M.; Robaeys, Geert] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. | - |
local.description.affiliation | [Koc, Ozgur M.; Robaeys, Geert] Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Koc, Ozgur M.; Oude Lashof, Astrid] Maastricht Univ, Dept Med Microbiol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Koc, Ozgur M.] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Kuypers, Dirk] Univ Hosp Leuven, Dept Nephrol & Renal Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Kuypers, Dirk; Van Cleemput, Johan] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium. | - |
local.description.affiliation | [Dupont, Lieven J.; Vos, Robin; Verleden, Geert] Univ Hosp Leuven, Dept Resp Dis, Leuven, Belgium. | - |
local.description.affiliation | [Van Keer, Jan M.; Van Cleemput, Johan] Univ Hosp Leuven, Dept Cardiol, Leuven, Belgium. | - |
local.description.affiliation | [Robaeys, Geert; Verbeek, Jef; Nevens, Frederik] Univ Hosp Leuven, Dept Gastroenterol & Hepatol, Leuven, Belgium. | - |
local.description.affiliation | [Kramer, Matthijs] Maastricht Univ, Med Ctr, Div Gastroenterol & Hepatol, Dept Internal Med, Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | KOC, Ozgur; Kuypers, Dirk; Dupont, Lieven J.; Vos, Robin; Van Keer, Jan M.; Van Cleemput, Johan; ROBAEYS, Geert; Oude Lashof, Astrid; Kramer, Matthijs; Verleden, Geert; Verbeek, Jef & Nevens, Frederik (2021) The effect of universal infant vaccination on the prevalence of hepatitis B immunity in adult solid organ transplant candidates. In: Journal of viral hepatitis, 28 (1), p. 105-111. | - |
item.accessRights | Open Access | - |
item.contributor | KOC, Ozgur | - |
item.contributor | Kuypers, Dirk | - |
item.contributor | Dupont, Lieven J. | - |
item.contributor | Vos, Robin | - |
item.contributor | Van Keer, Jan M. | - |
item.contributor | Van Cleemput, Johan | - |
item.contributor | ROBAEYS, Geert | - |
item.contributor | Oude Lashof, Astrid | - |
item.contributor | Kramer, Matthijs | - |
item.contributor | Verleden, Geert | - |
item.contributor | Verbeek, Jef | - |
item.contributor | Nevens, Frederik | - |
crisitem.journal.issn | 1352-0504 | - |
crisitem.journal.eissn | 1365-2893 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Journal of Viral Hepatitis - 2020 - Koc - The effect of universal infant vaccination on the prevalence of hepatitis B.pdf | Published version | 503 kB | Adobe PDF | View/Open |
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