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http://hdl.handle.net/1942/32874
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DC Field | Value | Language |
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dc.contributor.author | Ahmad, Ali | - |
dc.contributor.author | Corban, Michel T. | - |
dc.contributor.author | Toya, Takumi | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | Sara, Jaskanwal D. | - |
dc.contributor.author | Lerman, Lilach O. | - |
dc.contributor.author | Borlaug, Barry A. | - |
dc.contributor.author | Lerman, Amir | - |
dc.date.accessioned | 2020-12-10T15:25:01Z | - |
dc.date.available | 2020-12-10T15:25:01Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2020-12-01T10:27:45Z | - |
dc.identifier.citation | EUROPEAN JOURNAL OF HEART FAILURE, 23(5), p. 765-772 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32874 | - |
dc.description.abstract | Aims This study uniquely explored the relationship between coronary microvascular function and exercise haemodynamics using concurrent invasive testing. Methods and results Fifty-one consecutive patients with unexplained cardiac exertion symptoms, non-obstructive coronary artery disease and normal left ventricular ejection fraction (>50%) underwent haemodynamic exercise assessment and concurrent coronary reactivity testing. Heart failure with preserved ejection fraction (HFpEF) was defined as a pulmonary arterial wedge pressure (PAWP) >= 15 mmHg at rest and/or >= 25 mmHg at peak exercise. Endothelium-independent coronary microvascular dysfunction (CMD) was defined as a coronary flow reserve (CFR) <= 2.5, while endothelium-dependent CMD was defined as <= 50% increase in coronary blood flow (CBF) in response to intracoronary acetylcholine infusions. Patients with HFpEF (n= 22) had significantly lower CFR (2.5 +/- 0.6 vs. 3.2 +/- 0.7;P= 0.0003) and median %CBF increase in response to intracoronary acetylcholine [1 (-35; 34) vs. 64 (-4; 133);P= 0.002] compared to patients without HFpEF (n= 29). PAWP was significantly higher in patients with endothelium-independent CMD compared to controls during both rest and exercise. This significant elevation was only present during exercise in patients with endothelium-dependent CMD compared to controls. CFR had significant inverse correlations with PAWP at rest (r = -0.31;P= 0.03) and peak exercise (r = -0.47,P= 0.001). CFR also had positive correlations with maximal exercise capacity (in W/kg) (r = 0.33,P= 0.02). Conclusions Coronary microvascular function is inversely associated with filling pressures, particularly during exercise. Both types of CMD are associated with higher filling pressures at peak exercise. These findings underscore the potential mechanism and therapeutic target for CMD and HFpEF. | - |
dc.description.sponsorship | This work was supported by Mayo institutional funding. F.H.V. is supported by a Fellowship of the Belgian American Educational Foundation (B.A.E.F.) and by the Special Research Fund (BOF) of Hasselt University (BOF19PD04). B.A.B. is supported by RO1 HL128526. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject.other | Heart failure with preserved ejection fraction | - |
dc.subject.other | Microvascular dysfunction | - |
dc.subject.other | Exercise haemodynamics | - |
dc.title | Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 772 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 765 | - |
dc.identifier.volume | 23 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Lerman, A (corresponding author), Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA. | - |
dc.description.notes | lerman.amir@mayo.edu | - |
dc.description.other | Lerman, A (corresponding author), Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA. lerman.amir@mayo.edu | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ejhf.2010 | - |
dc.identifier.isi | WOS:000575808500001 | - |
dc.contributor.orcid | Verbrugge, Frederik Hendrik/0000-0003-0599-9290; Ahmad, | - |
dc.contributor.orcid | Ali/0000-0001-9669-8009 | - |
dc.identifier.eissn | - | |
dc.identifier.eissn | 1879-0844 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Ahmad, Ali; Corban, Michel T.; Toya, Takumi; Verbrugge, Frederik H.; Sara, Jaskanwal D.; Borlaug, Barry A.; Lerman, Amir] Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA. | - |
local.description.affiliation | [Toya, Takumi] Natl Def Med Coll, Div Cardiol, Tokorozawa, Saitama, Japan. | - |
local.description.affiliation | [Verbrugge, Frederik H.] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Hasselt, Belgium. | - |
local.description.affiliation | [Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA. | - |
local.uhasselt.international | yes | - |
item.contributor | Ahmad, Ali | - |
item.contributor | Corban, Michel T. | - |
item.contributor | Toya, Takumi | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | Sara, Jaskanwal D. | - |
item.contributor | Lerman, Lilach O. | - |
item.contributor | Borlaug, Barry A. | - |
item.contributor | Lerman, Amir | - |
item.validation | ecoom 2021 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Ahmad, Ali; Corban, Michel T.; Toya, Takumi; VERBRUGGE, Frederik; Sara, Jaskanwal D.; Lerman, Lilach O.; Borlaug, Barry A. & Lerman, Amir (2021) Coronary microvascular dysfunction is associated with exertional haemodynamic abnormalities in patients with heart failure with preserved ejection fraction. In: EUROPEAN JOURNAL OF HEART FAILURE, 23(5), p. 765-772. | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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European J of Heart Fail - 2020 - Ahmad - Coronary microvascular dysfunction is associated with exertional haemodynamic.pdf | Published version | 3.33 MB | Adobe PDF | View/Open |
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