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http://hdl.handle.net/1942/32879
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DC Field | Value | Language |
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dc.contributor.author | Finamore, Panaiotis | - |
dc.contributor.author | Janssen, Daisy J. A. | - |
dc.contributor.author | Schols, Jos M. G. A. | - |
dc.contributor.author | Verstraeten, Els R. N. | - |
dc.contributor.author | Antonelli Incalzi, Raffaele | - |
dc.contributor.author | Wouters, Emiel F. M. | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.date.accessioned | 2020-12-11T10:16:26Z | - |
dc.date.available | 2020-12-11T10:16:26Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2020-11-24T13:49:05Z | - |
dc.identifier.citation | Aging Clinical and Experimental Research (Print), 33 (2), p. 419-428 | - |
dc.identifier.issn | 1594-0667 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32879 | - |
dc.description.abstract | Background Healthcare needs are complex and heterogeneous in advanced chronic organ failure. However, based on symptom clusters, groups of patients with similar quality of life, care dependency and life-sustaining treatment preferences can be identified. Aims To evaluate the stability of symptom-based clusters over time, and whether and to what extent the clusters are able to predict patients' 2-year survival and hospitalization rates. Methods This is a secondary analysis of a longitudinal observational study including 95 outpatients with chronic obstructive pulmonary disease (COPD) GOLD stage III-IV, 80 outpatients with chronic heart failure (CHF) NYHA stage III-IV and 80 outpatients with chronic renal failure (CRF) requiring dialysis. Patients were clustered into three groups applying K-means algorithm on baseline symptoms' severity and were then longitudinally evaluated. 2-year survival and hospital admissions during 1 year were estimated using Kaplan-Meier curves and Cox models. 1-year tendencies in symptom variation, using mixed linear models, and clusters comparison over time were performed. Results The three clusters were unable to predict patients' survival and hospital admissions. Noteworthy, they show different trajectories of symptom variation, with Cluster 1 patients experiencing a worsening of symptoms, associated with an increased care dependency, and Cluster 2 and Cluster 3 patients being stable or having a relief in some symptoms. Although Cluster 1 is becoming more similar to Cluster 2, the three clusters preserve the overall characteristics and differences. Discussion Symptom-based clusters might help to identify patients with different trajectories of symptom variations. Conclusion Symptom clusters do not predict survival and hospital admissions and are stable over time. | - |
dc.description.sponsorship | This project was supported by: Proteion Thuis, Horn, The Netherlands; CIRO +, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; Netherlands Asthma Foundation [Grant 3.4.06.082], Leusden, The Netherlands; Stichting Wetenschapsbevordering Verpleeghuiszorg (SWBV), Utrecht, The Netherlands. No funding source had any role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject.other | Chronic obstructive pulmonary disease | - |
dc.subject.other | Congestive heart failure | - |
dc.subject.other | Chronic renal failure | - |
dc.subject.other | Dialysis | - |
dc.subject.other | Symptoms | - |
dc.subject.other | Cluster analysis | - |
dc.title | Symptom-based clusters in patients with advanced chronic organ failure identify different trajectories of symptom variations | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 428 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 419 | - |
dc.identifier.volume | 33 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Finamore, P (corresponding author), Campus Biomed Univ, Dept Med, Unit Geriatr, Via Alvaro del Portillo 200, I-00128 Rome, Italy.; Finamore, P (corresponding author), Teaching Hosp, Via Alvaro del Portillo 200, I-00128 Rome, Italy. | - |
dc.description.notes | p.finamore@unicampus.it | - |
dc.description.other | Finamore, P (corresponding author), Campus Biomed Univ, Dept Med, Unit Geriatr, Via Alvaro del Portillo 200, I-00128 Rome, Italy ; Teaching Hosp, Via Alvaro del Portillo 200, I-00128 Rome, Italy. p.finamore@unicampus.it | - |
local.publisher.place | ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s40520-020-01711-z | - |
dc.identifier.isi | WOS:000571373100001 | - |
dc.identifier.eissn | 1720-8319 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Finamore, Panaiotis; Antonelli Incalzi, Raffaele] Campus Biomed Univ, Dept Med, Unit Geriatr, Via Alvaro del Portillo 200, I-00128 Rome, Italy. | - |
local.description.affiliation | [Finamore, Panaiotis; Antonelli Incalzi, Raffaele] Teaching Hosp, Via Alvaro del Portillo 200, I-00128 Rome, Italy. | - |
local.description.affiliation | [Janssen, Daisy J. A.; Wouters, Emiel F. M.; Spruit, Martijn A.] Ciro, Dept Res & Dev, Horn, Netherlands. | - |
local.description.affiliation | [Janssen, Daisy J. A.] Maastricht Univ, Dept Hlth Serv Res, Care & Publ Hlth Res Inst, Maastricht, Netherlands. | - |
local.description.affiliation | [Schols, Jos M. G. A.] Maastricht Univ Med Ctr MUMC, Dept Hlth Serv Res, Maastricht, Netherlands. | - |
local.description.affiliation | [Verstraeten, Els R. N.] Proteion, Horn, Netherlands. | - |
local.description.affiliation | [Wouters, Emiel F. M.; Spruit, Martijn A.] Maastricht Univ Med Ctr MUMC, Dept Resp Med, Maastricht, Netherlands. | - |
local.description.affiliation | [Spruit, Martijn A.] Hasselt Univ, REVAL Rehabil Res Ctr, BIOMED Biomed Res Inst, Fac Rehabil Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Spruit, Martijn A.] NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Finamore, Panaiotis; Janssen, Daisy J. A.; Schols, Jos M. G. A.; Verstraeten, Els R. N.; Antonelli Incalzi, Raffaele; Wouters, Emiel F. M. & SPRUIT, Martijn A. (2021) Symptom-based clusters in patients with advanced chronic organ failure identify different trajectories of symptom variations. In: Aging Clinical and Experimental Research (Print), 33 (2), p. 419-428. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | Finamore, Panaiotis | - |
item.contributor | Janssen, Daisy J. A. | - |
item.contributor | Schols, Jos M. G. A. | - |
item.contributor | Verstraeten, Els R. N. | - |
item.contributor | Antonelli Incalzi, Raffaele | - |
item.contributor | Wouters, Emiel F. M. | - |
item.contributor | SPRUIT, Martijn A. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1594-0667 | - |
crisitem.journal.eissn | 1720-8319 | - |
Appears in Collections: | Research publications |
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s40520-020-01711-z.pdf Restricted Access | Published version | 706.11 kB | Adobe PDF | View/Open Request a copy |
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