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Title: | DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability | Authors: | Banimohamad-shotorbani, Behnaz KAHROBA, Houman Sadeghzadeh, Hadi WILSON, David Maadi, Hamid Samadi, Nasser Hejazi, Mohammad Saeid Farajpour, Hekmat Onari, Behzad Nemati Sadeghi, Mohammad Reza |
Issue Date: | 2020 | Publisher: | ELSEVIER IRELAND LTD | Source: | AGEING RESEARCH REVIEWS, 62 (Art N° 101125) | Abstract: | Mesenchymal stromal cells (MSCs) are heterogeneous and contain several populations, including stem cells. MSCs' secretome has the ability to induce proliferation, differentiation, chemo-attraction, anti-apoptosis, and immunomodulation activities in stem cells. Moreover, these cells recognize tissue damage caused by drugs, radiation (e.g., Ultraviolet, infra-red) and oxidative stress, and respond in two ways: either MSCs differentiate into particular cell lineages to preserve tissue homeostasis, or they release a regenerative secretome to activate tissue repairing mechanisms. The maintenance of MSCs in quiescence can increase the incidence and accumulation of various forms of genomic modifications, particularly upon environmental insults. Thus, dysregulated DNA repair pathways can predispose MSCs to senescence or apoptosis, reducing their stemness and self-renewal properties. For instance, DNA damage can impair telomere replication, activating DNA damage checkpoints to maintain MSC function. In this review, we aim to summarize the role of DNA damage and associated repair responses in MSC senescence, differentiation and programmed cell death. | Notes: | Kahroba, H; Sadeghi, MR (corresponding author), Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Mol Med, Tabriz, Iran. houman.kahroba@yahoo.com; sadegimohammadreza@gmail.com |
Other: | Kahroba, H; Sadeghi, MR (corresponding author), Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Mol Med, Tabriz, Iran. houman.kahroba@yahoo.com; sadegimohammadreza@gmail.com | Keywords: | Malignancy;Base excision repair;Nucleotide excision repair;Homologous recombination;Non-homologous end joining;Mismatch repair | Document URI: | http://hdl.handle.net/1942/32880 | ISSN: | 1568-1637 | e-ISSN: | 1872-9649 | DOI: | 10.1016/j.arr.2020.101125 | ISI #: | WOS:000571829300005 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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1-s2.0-S1568163720302609-main.pdf Restricted Access | Published version | 1.88 MB | Adobe PDF | View/Open Request a copy |
author version.pdf | Peer-reviewed author version | 1.75 MB | Adobe PDF | View/Open |
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