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http://hdl.handle.net/1942/32926
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DC Field | Value | Language |
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dc.contributor.author | Roggeri, Alessandra | - |
dc.contributor.author | SCHEPERS, Melissa | - |
dc.contributor.author | TIANE, Assia | - |
dc.contributor.author | ROMBAUT, Ben | - |
dc.contributor.author | VAN VEGGEL, Lieve | - |
dc.contributor.author | HELLINGS, Niels | - |
dc.contributor.author | Prickaerts, Jos | - |
dc.contributor.author | Pittaluga, Anna | - |
dc.contributor.author | VANMIERLO, Tim | - |
dc.date.accessioned | 2020-12-15T10:43:12Z | - |
dc.date.available | 2020-12-15T10:43:12Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-12-15T09:02:06Z | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (20) (Art N° 7537) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32926 | - |
dc.description.abstract | Multiple sclerosis (MS) is an autoimmune inflammatory disease characterized by demyelination, axonal loss, and synaptic impairment in the central nervous system (CNS). The available therapies aim to reduce the severity of the pathology during the early inflammatory stages, but they are not effective in the chronic stage of the disease. In this phase, failure in endogenous remyelination is associated with the impairment of oligodendrocytes progenitor cells (OPCs) to migrate and differentiate into mature myelinating oligodendrocytes. Therefore, stimulating differentiation of OPCs into myelinating oligodendrocytes has become one of the main goals of new therapeutic approaches for MS. Different disease-modifying therapies targeting sphingosine-1-phosphate receptors (S1PRs) have been approved or are being developed to treat MS. Besides their immunomodulatory effects, growing evidence suggests that targeting S1PRs modulates mechanisms beyond immunomodulation, such as remyelination. In this context, this review focuses on the current understanding of S1PR modulators and their direct effect on OPCs and oligodendrocytes. | - |
dc.description.sponsorship | This work was funded by "stichting charcot foundation" and "FWO". | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | Sphingosine-1-phosphate receptor modulators | - |
dc.subject.other | OPC | - |
dc.subject.other | oligodendrocyte | - |
dc.subject.other | demyelination | - |
dc.subject.other | multiple sclerosis | - |
dc.title | Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 20 | - |
dc.identifier.volume | 21 | - |
local.format.pages | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Vanmierlo, T (corresponding author), Hasselt Univ, Biomed Res Inst, Neuroimmune Connect & Repair Lab, B-3500 Hasselt, Belgium.; Vanmierlo, T (corresponding author), Maastricht Univ, Sch Mental Hlth & Neurosci, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands. | - |
dc.description.notes | roggeri@difar.unige.it; melissa.schepers@uhasselt.be; | - |
dc.description.notes | assia.tiane@uhasselt.be; ben.rombaut@uhasselt.be; | - |
dc.description.notes | lieve.vanveggel@uhasselt.be; niels.hellings@uhasselt.be; | - |
dc.description.notes | jos.prickaerts@maastrichtuniversity.nl; pittalug@difar.unige.it; | - |
dc.description.notes | tim.vanmierlo@uhasselt.be | - |
dc.description.other | Vanmierlo, T (corresponding author), Hasselt Univ, Biomed Res Inst, Neuroimmune Connect & Repair Lab, B-3500 Hasselt, Belgium ; Maastricht Univ, Sch Mental Hlth & Neurosci, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands. roggeri@difar.unige.it; melissa.schepers@uhasselt.be; assia.tiane@uhasselt.be; ben.rombaut@uhasselt.be; lieve.vanveggel@uhasselt.be; niels.hellings@uhasselt.be; jos.prickaerts@maastrichtuniversity.nl; pittalug@difar.unige.it; tim.vanmierlo@uhasselt.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 7537 | - |
dc.identifier.doi | 10.3390/ijms21207537 | - |
dc.identifier.isi | WOS:000582999000001 | - |
dc.contributor.orcid | Vanmierlo, Tim/0000-0003-2912-0578; Pittaluga, Anna/0000-0002-4011-1165 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Roggeri, Alessandra] Univ Genoa, Dept Pharm DiFar, Viale Cembrano 4, I-16148 Genoa, Italy. | - |
local.description.affiliation | [Schepers, Melissa; Tiane, Assia; Rombaut, Ben; van Veggel, Lieve; Hellings, Niels; Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst, Neuroimmune Connect & Repair Lab, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Schepers, Melissa; Tiane, Assia; Rombaut, Ben; van Veggel, Lieve; Prickaerts, Jos; Vanmierlo, Tim] Maastricht Univ, Sch Mental Hlth & Neurosci, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [Pittaluga, Anna] Univ Genoa, Ctr 3Rs, Ctr Excellence Biomed Res, Dept Pharm DiFar, Viale Cembrano 4, I-16148 Genoa, Italy. | - |
local.description.affiliation | [Pittaluga, Anna] IRCCS Osped Policlin San Martino, I-16145 Genoa, Italy. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.contributor | Roggeri, Alessandra | - |
item.contributor | SCHEPERS, Melissa | - |
item.contributor | TIANE, Assia | - |
item.contributor | ROMBAUT, Ben | - |
item.contributor | VAN VEGGEL, Lieve | - |
item.contributor | HELLINGS, Niels | - |
item.contributor | Prickaerts, Jos | - |
item.contributor | Pittaluga, Anna | - |
item.contributor | VANMIERLO, Tim | - |
item.accessRights | Open Access | - |
item.fullcitation | Roggeri, Alessandra; SCHEPERS, Melissa; TIANE, Assia; ROMBAUT, Ben; VAN VEGGEL, Lieve; HELLINGS, Niels; Prickaerts, Jos; Pittaluga, Anna & VANMIERLO, Tim (2020) Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21 (20) (Art N° 7537). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1661-6596 | - |
crisitem.journal.eissn | 1422-0067 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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ijms-21-07537.pdf | Published version | 775.58 kB | Adobe PDF | View/Open |
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