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http://hdl.handle.net/1942/32946
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DC Field | Value | Language |
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dc.contributor.author | ALFANO, Rossella | - |
dc.contributor.author | Chadeau-Hyam, Marc | - |
dc.contributor.author | Ghantous, Akram | - |
dc.contributor.author | Keski-Rahkonen, Pekka | - |
dc.contributor.author | Chatzi, Leda | - |
dc.contributor.author | Perez, Almudena Espin | - |
dc.contributor.author | Herceg, Zdenko | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | DE KOK, Theo | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Novoloaca, Alexei | - |
dc.contributor.author | Patel, Chirag J. | - |
dc.contributor.author | Pizzi, Costanza | - |
dc.contributor.author | Robinot, Nivonirina | - |
dc.contributor.author | Rusconi, Franca | - |
dc.contributor.author | Scalbert, Augustin | - |
dc.contributor.author | Sunyer, Jordi | - |
dc.contributor.author | Vermeulen, Roel | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.contributor.author | Vineis, Paolo | - |
dc.contributor.author | Robinson, Oliver | - |
dc.contributor.author | PLUSQUIN, Michelle | - |
dc.date.accessioned | 2020-12-15T14:47:46Z | - |
dc.date.available | 2020-12-15T14:47:46Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-11-17T13:19:25Z | - |
dc.identifier.citation | METABOLISM-CLINICAL AND EXPERIMENTAL, 110 (Art N° 154292) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32946 | - |
dc.description.abstract | Background: Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains limited. Methods: To investigate the systems biology of birthweight, we (Toss-sectionally integrated the methylome, the transcriptome, the metabolome and a set of inflammatory proteins measured in cord blood samples, collected from four birth-cohorts (n = 489). We focused on two sets of 68 metabolites and 903 CpGs previously related to birthweight and investigated the correlation structures existing between these two sets and all other omic features via bipartite Pearson correlations. Results: This dataset revealed that the set of metabolome and methylome signatures of birthweight have seven signals in common, including three metabolites [PC(34:2), plasmalogen PC(36:4)/PC(0-36:5), and a compound with m/z of 781.0545], two CpGs (on the DHCR24 and SC4MOL gene), and two proteins (periostin and CCL22). CCL22, a macrophage-derived chemokine has not been previously identified in relation to birthweight. Since the results of the omics integration indicated the central role of cholesterol metabolism, we explored the association of cholesterol levels in cord blood with birthweight in the ENVIRONAGE cohort (n 1097), finding that higher birthweight was associated with increased high-density lipoprotein cholesterol and that high-density lipoprotein cholesterol was lower in small versus large for gestational age newborns. Conclusions: Our data suggests that an integration of different omic-layers in addition to single omics studies is a useful approach to generate new hypotheses regarding biological mechanisms. CCL22 and cholesterol metabolism in cord blood play a mechanistic role in birthweight. Crown Copyright (C) 2020 Published by Elsevier Inc. | - |
dc.description.sponsorship | This work is supported by the Bijzonder Onderzoeksfonds (BOF) Hasselt University through a PhD fellowship [to RA], the "EXPOsOMICS" grant [grant number 308610-FP7 European Commission to PV], and the "STOP" grant [grant number 774548-European Commission H2020 to PV]. The ENVIRONAGE birth-cohort is supported by the EU Program "Ideas" (ERC-2012-StG-310898) and the FWO (G082317N). Piccolipiu cohort has been funded by the CCMgrant 2010 and the ItalianMinistry ofHealth. | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.rights | © 2020 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.subject.other | Birth weight | - |
dc.subject.other | Cholesterol | - |
dc.subject.other | DNA methylation | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Metabolome | - |
dc.subject.other | Proteins | - |
dc.title | A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 110 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Plusquin, M (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | michelle.plusquin@uhasselt.be | - |
dc.description.other | Plusquin, M (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. michelle.plusquin@uhasselt.be | - |
local.publisher.place | 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 154292 | - |
dc.identifier.doi | 10.1016/j.metabol.2020.154292 | - |
dc.identifier.isi | WOS:000563770500012 | - |
dc.contributor.orcid | Reis, AlessanRSS/0000-0001-8486-7469; Chadeau-Hyam, | - |
dc.contributor.orcid | Marc/0000-0001-8341-5436 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Alfano, Rossella; Chadeau-Hyam, Marc; Vermeulen, Roel; Vineis, Paolo; Robinson, Oliver; Plusquin, Michelle] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. | - |
local.description.affiliation | [Alfano, Rossella; Chadeau-Hyam, Marc; Vineis, Paolo; Plusquin, Michelle] Imperial Coll London, Hlth Protect Agcy, Ctr Environm & Hlth, MRC, London, England. | - |
local.description.affiliation | [Alfano, Rossella; Nawrot, Tim S.; Plusquin, Michelle] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Chadeau-Hyam, Marc; Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci IRAS, Div Environm Epidemiol, Utrecht, Netherlands. | - |
local.description.affiliation | [Ghantous, Akram; Keski-Rahkonen, Pekka; Herceg, Zdenko; Novoloaca, Alexei; Robinot, Nivonirina; Scalbert, Augustin] Int Agcy Res Canc IARC, 150 Cours Albert Thomas, F-69008 Lyon, France. | - |
local.description.affiliation | [Chatzi, Leda] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA. | - |
local.description.affiliation | [Chatzi, Leda] Univ Crete, Dept Social Med, Iraklion, Greece. | - |
local.description.affiliation | [Perez, Almudena Espin] Stanford Univ, Dept Biomed Informat Res, Stanford, CA 94305 USA. | - |
local.description.affiliation | [Kogevinas, Manolis; Vrijheid, Martine] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain. | - |
local.description.affiliation | [Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain. | - |
local.description.affiliation | [Kogevinas, Manolis; Sunyer, Jordi] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain. | - |
local.description.affiliation | [Kogevinas, Manolis; Sunyer, Jordi; Vrijheid, Martine] Univ Pompeu Fabra UPF, Barcelona, Catalonia, Spain. | - |
local.description.affiliation | [de Kok, Theo M.] Maastricht Univ, Dept Toxicogen, Maastricht, Netherlands. | - |
local.description.affiliation | [Nawrot, Tim S.] Leuven Univ, Environm & Hlth Unit, Leuven, Belgium. | - |
local.description.affiliation | [Patel, Chirag J.] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA. | - |
local.description.affiliation | [Pizzi, Costanza] Univ Turin, Dept Med Sci, Turin, Italy. | - |
local.description.affiliation | [Pizzi, Costanza] CPO Piemonte, Turin, Italy. | - |
local.description.affiliation | [Rusconi, Franca] Anna Meyer Childrens Univ Hosp, Unit Epidemiol, Florence, Italy. | - |
local.description.affiliation | [Vineis, Paolo] Human Genet Fdn HuGeF, Turin, Italy. | - |
local.uhasselt.international | yes | - |
item.fullcitation | ALFANO, Rossella; Chadeau-Hyam, Marc; Ghantous, Akram; Keski-Rahkonen, Pekka; Chatzi, Leda; Perez, Almudena Espin; Herceg, Zdenko; Kogevinas, Manolis; DE KOK, Theo; NAWROT, Tim; Novoloaca, Alexei; Patel, Chirag J.; Pizzi, Costanza; Robinot, Nivonirina; Rusconi, Franca; Scalbert, Augustin; Sunyer, Jordi; Vermeulen, Roel; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver & PLUSQUIN, Michelle (2020) A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism. In: METABOLISM-CLINICAL AND EXPERIMENTAL, 110 (Art N° 154292). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | ALFANO, Rossella | - |
item.contributor | Chadeau-Hyam, Marc | - |
item.contributor | Ghantous, Akram | - |
item.contributor | Keski-Rahkonen, Pekka | - |
item.contributor | Chatzi, Leda | - |
item.contributor | Perez, Almudena Espin | - |
item.contributor | Herceg, Zdenko | - |
item.contributor | Kogevinas, Manolis | - |
item.contributor | DE KOK, Theo | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Novoloaca, Alexei | - |
item.contributor | Patel, Chirag J. | - |
item.contributor | Pizzi, Costanza | - |
item.contributor | Robinot, Nivonirina | - |
item.contributor | Rusconi, Franca | - |
item.contributor | Scalbert, Augustin | - |
item.contributor | Sunyer, Jordi | - |
item.contributor | Vermeulen, Roel | - |
item.contributor | Vrijheid, Martine | - |
item.contributor | Vineis, Paolo | - |
item.contributor | Robinson, Oliver | - |
item.contributor | PLUSQUIN, Michelle | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0026-0495 | - |
crisitem.journal.eissn | 1532-8600 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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PIIS0026049520301566.pdf | Published version | 3.09 MB | Adobe PDF | View/Open |
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