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http://hdl.handle.net/1942/32947
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DC Field | Value | Language |
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dc.contributor.author | Al-Mashhadi, Z. | - |
dc.contributor.author | Viggers, R. | - |
dc.contributor.author | Fuglsang-Nielsen, R. | - |
dc.contributor.author | de Vries, F. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | Harslof, T. | - |
dc.contributor.author | Langdahl, B. | - |
dc.contributor.author | Gregersen, S. | - |
dc.contributor.author | Starup-Linde, Jakob | - |
dc.date.accessioned | 2020-12-15T14:50:12Z | - |
dc.date.available | 2020-12-15T14:50:12Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-12-15T14:09:29Z | - |
dc.identifier.citation | Current Osteoporosis Reports, 18 (6) , p. 737 -758 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32947 | - |
dc.description.abstract | Purpose of Review Diabetes mellitus (DM) is associated with increased fracture risk. The aim of this systematic review was to examine the effects of different classes of glucose-lowering drugs on fracture risk in patients with type 2 DM. The heterogeneity of the included studies did not allow formal statistical analyses. Recent Findings Sixty studies were included in the review. Metformin, dipeptidylpeptidase-IV inhibitors, glucagon-like peptide-1 receptor agonists, and sodium-glucose cotransporter 2-inhibitors do not appear to increase fracture risk. Results for insulin and sulphonylureas were more disparate, although there may be an increased fracture risk related to hypoglycemia and falls with these treatments. Glitazones were consistently associated with increased fracture risk in women, although the evidence was sparser in men. New glucose-lowering drugs are continuously being developed and better understanding of these is leading to changes in prescription patterns. Our findings warrant continued research on the effects of glucose-lowering drugs on fracture risk, elucidating the class-specific effects of these drugs. | - |
dc.description.sponsorship | This work has received funding by Steno Collaborative grant, Novo Nordisk Foundation Denmark (Grant no. NNF18OC0052064). | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject.other | Type 2 diabetes | - |
dc.subject.other | Fracture | - |
dc.subject.other | Glucose-lowering drugs | - |
dc.subject.other | Antidiabetics | - |
dc.subject.other | Glitazones | - |
dc.subject.other | Insulin | - |
dc.subject.other | Systematic review | - |
dc.title | Glucose-Lowering Drugs and Fracture Risk—a Systematic Review | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 758 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 737 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 22 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Starup-Linde, J (corresponding author), Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.; Starup-Linde, J (corresponding author), Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Palle Juul Jensens Blvd 99, DK-8220 Aarhus N, Denmark. | - |
dc.description.notes | jakolind@rm.dk | - |
dc.description.other | Starup-Linde, J (corresponding author), Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark ; Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Palle Juul Jensens Blvd 99, DK-8220 Aarhus N, Denmark. jakolind@rm.dk | - |
local.publisher.place | ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1007/s11914-020-00638-8 | - |
dc.identifier.isi | WOS:000587966700001 | - |
dc.contributor.orcid | Al-Mashhadi, Zheer/0000-0003-1201-199X; Linde, Jakob | - |
dc.contributor.orcid | Starup/0000-0002-4325-8023 | - |
dc.identifier.eissn | - | |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Al-Mashhadi, Z.; Fuglsang-Nielsen, R.; Gregersen, S.; Starup-Linde, Jakob] Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark. | - |
local.description.affiliation | [Al-Mashhadi, Z.; Langdahl, B.] Aarhus Univ, Dept Clin Med, Aarhus, Denmark. | - |
local.description.affiliation | [Viggers, R.] Aalborg Univ Hosp, Steno Diabet Ctr North Jutland, Aalborg, Denmark. | - |
local.description.affiliation | [Viggers, R.] Aalborg Univ, Dept Clin Med, Aalborg, Denmark. | - |
local.description.affiliation | [Fuglsang-Nielsen, R.] Reg Hosp Horsens, Dept Internal Med, Horsens, Denmark. | - |
local.description.affiliation | [de Vries, F.] Maastricht Univ Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands. | - |
local.description.affiliation | [de Vries, F.] Utrecht Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. | - |
local.description.affiliation | [van den Bergh, J. P.] Maastricht Univ Med Ctr, Dept Internal Med, Maastricht, Netherlands. | - |
local.description.affiliation | [van den Bergh, J. P.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands. | - |
local.description.affiliation | [van den Bergh, J. P.] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Harslof, T.; Langdahl, B.; Gregersen, S.; Starup-Linde, Jakob] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Palle Juul Jensens Blvd 99, DK-8220 Aarhus N, Denmark. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Al-Mashhadi, Z.; Viggers, R.; Fuglsang-Nielsen, R.; de Vries, F.; VAN DEN BERGH, Joop; Harslof, T.; Langdahl, B.; Gregersen, S. & Starup-Linde, Jakob (2020) Glucose-Lowering Drugs and Fracture Risk—a Systematic Review. In: Current Osteoporosis Reports, 18 (6) , p. 737 -758. | - |
item.fulltext | With Fulltext | - |
item.contributor | Al-Mashhadi, Z. | - |
item.contributor | Viggers, R. | - |
item.contributor | Fuglsang-Nielsen, R. | - |
item.contributor | de Vries, F. | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | Harslof, T. | - |
item.contributor | Langdahl, B. | - |
item.contributor | Gregersen, S. | - |
item.contributor | Starup-Linde, Jakob | - |
crisitem.journal.issn | 1544-1873 | - |
crisitem.journal.eissn | 1544-2241 | - |
Appears in Collections: | Research publications |
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2020_Article_ (2).pdf Restricted Access | Published version | 587.21 kB | Adobe PDF | View/Open Request a copy |
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