Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/32968
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wijtvliet, Veerle | - |
dc.contributor.author | Plaeke, Philip | - |
dc.contributor.author | ABRAMS, Steven | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Gielis, Els | - |
dc.contributor.author | Hellemans, Rachel | - |
dc.contributor.author | De Winter, Benedicte | - |
dc.contributor.author | Abramowicz, Daniel | - |
dc.contributor.author | Ledeganck, Kristien | - |
dc.date.accessioned | 2020-12-17T11:10:09Z | - |
dc.date.available | 2020-12-17T11:10:09Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-11-17T13:55:03Z | - |
dc.identifier.citation | NEPHROLOGY DIALYSIS TRANSPLANTATION, 35 (S3) , p. 190 -190 (Art N° TO009) | - |
dc.identifier.uri | http://hdl.handle.net/1942/32968 | - |
dc.description.abstract | Background and Aims: Donor-derived cell-free DNA (dd-cfDNA) is actively studied as a non-invasive biomarker for the diagnosis of kidney allograft rejection, with conflicting results being reported. Therefore, we conducted a systematic review and meta-analysis to provide a clear overview of the potential value of dd-cfDNA to diagnose kidney rejection, and specifically antibody-mediated rejection (ABMR). Method: A systematic literature search was performed in Pubmed, Web of Science, and the Cochrane library using the search terms: "cell free DNA AND kidney transplantation". We included studies that 1) described dd-cfDNA fractions in blood of kidney allograft recipients; and 2) were published as English original research papers between January 1, 1994 and November 26, 2019. The methodological quality was assessed by the Methodological Index for Non-Randomized Studies (MINORS). Out of 287 hits, 55 duplicates were removed. 232 remaining abstracts were screened, leaving 36 articles for full-text review, of which 11 were included in a systematic review and data from 7 articles were synthesized in a meta-analysis. A weighted median of medians (WMM) (median with 95% confidence interval (CI) in squared brackets) was computed as a pooled estimate for the median dd-cfDNA fractions in different groups of patients. A meta-analysis was prespecified to be performed among following patient groups: 1) ABMR patients; 2) T-cell-mediated rejection (TCMR) patients; 3) stable patients; 4) patients without rejection at indication biopsy. The pooled ABMR group consisted of patient groups with pure ABMR and/or mixed ABMR/TCMR. Weighted median differences of medians (WMDM) were estimated for pairwise comparisons among the aforementioned groups, according to the approach proposed by McGrath et al. (2019). | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | THE POTENTIAL OF DONOR-DERIVED CELL-FREE DNA AS A BIOMARKER FOR REJECTION IN KIDNEY TRANSPLANTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencedate | JUN 06-09, 2020 | - |
local.bibliographicCitation.conferencename | 57th ERA-EDTA Congress | - |
local.bibliographicCitation.conferenceplace | ELECTR NETWORK | - |
dc.identifier.epage | 190 | - |
dc.identifier.issue | S3 | - |
dc.identifier.spage | 190 | - |
dc.identifier.volume | 35 | - |
local.format.pages | 1 | - |
local.bibliographicCitation.jcat | M | - |
local.publisher.place | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
local.bibliographicCitation.artnr | TO009 | - |
dc.identifier.isi | WOS:000562392102167 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Wijtvliet, Veerle; Plaeke, Philip; Gielis, Els; Hellemans, Rachel; De Winter, Benedicte; Abramowicz, Daniel; Ledeganck, Kristien] Univ Antwerp, Lab Expt Med & Paediat, Antwerp, Belgium. | - |
local.description.affiliation | [Wijtvliet, Veerle; Plaeke, Philip; Gielis, Els; Hellemans, Rachel; De Winter, Benedicte; Abramowicz, Daniel; Ledeganck, Kristien] Infla Med Ctr Excellence, Antwerp, Belgium. | - |
local.description.affiliation | [Plaeke, Philip] Antwerp Univ Hosp, Dept Abdominal Surg, Antwerp, Belgium. | - |
local.description.affiliation | [Abrams, Steven] Univ Antwerp, Global Hlth Inst, Dept Epidemiol & Social Med, Antwerp, Belgium. | - |
local.description.affiliation | [Abrams, Steven; Hens, Niel] Hasselt Univ, Ctr Stat, BioStat 1, Data Sci Inst, Diepenbeek, Belgium. | - |
local.description.affiliation | [Hens, Niel] Univ Antwerp, Ctr Hlth Econ Res & Modelling Infect Dis, Antwerp, Belgium. | - |
local.description.affiliation | [Hens, Niel] Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, Antwerp, Belgium. | - |
local.description.affiliation | [Hellemans, Rachel; Abramowicz, Daniel] Antwerp Univ Hosp, Dept Hypertens & Nephrol, Antwerp, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Wijtvliet, Veerle; Plaeke, Philip; ABRAMS, Steven; HENS, Niel; Gielis, Els; Hellemans, Rachel; De Winter, Benedicte; Abramowicz, Daniel & Ledeganck, Kristien (2020) THE POTENTIAL OF DONOR-DERIVED CELL-FREE DNA AS A BIOMARKER FOR REJECTION IN KIDNEY TRANSPLANTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS. In: NEPHROLOGY DIALYSIS TRANSPLANTATION, 35 (S3) , p. 190 -190 (Art N° TO009). | - |
item.contributor | Wijtvliet, Veerle | - |
item.contributor | Plaeke, Philip | - |
item.contributor | ABRAMS, Steven | - |
item.contributor | HENS, Niel | - |
item.contributor | Gielis, Els | - |
item.contributor | Hellemans, Rachel | - |
item.contributor | De Winter, Benedicte | - |
item.contributor | Abramowicz, Daniel | - |
item.contributor | Ledeganck, Kristien | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0931-0509 | - |
crisitem.journal.eissn | 1460-2385 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ordner1.pdf Restricted Access | Peer-reviewed author version | 243.23 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.