Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/32979
Title: | Ivermectin Treatment Response in Onchocerca Volvulus Infected Persons with Epilepsy: A Three-Country Short Cohort Study | Authors: | Dusabimana, Alfred Bhwana, Dan Raimon, Stephen Mmbando, Bruno P. Hotterbeekx, An Tepage, Floribert Mandro, Michel Fodjo, Joseph N. Siewe ABRAMS, Steven Colebunders, Robert |
Issue Date: | 2020 | Publisher: | MDPI | Source: | PATHOGENS, 9 (8) (Art N° 617). | Abstract: | Despite a long history of community-directed treatment with ivermectin (CDTI), a high ongoingOnchocerca volvulustransmission is observed in certain onchocerciasis-endemic regions in Africa with a high prevalence of epilepsy. We investigated factors associated with higher microfilarial (mf) density after ivermectin treatment. Skin snips were obtained fromO. volvulus-infected persons with epilepsy before, and 3 to 5 months after ivermectin treatment. Participants were enrolled from 4 study sites: Maridi (South Sudan); Logo and Aketi (Democratic Republic of Congo); and Mahenge (Tanzania). Of the 329 participants, 105 (31.9%) had a post-treatment mf density >20% of the pre-treatment value. The percentage reduction in the geometric mean mf density ranged from 69.0% (5 months after treatment) to 89.4% (3 months after treatment). A higher pre-treatment mf density was associated with increased probability of a positive skin snip after ivermectin treatment (p= 0.016). For participants with persistent microfiladermia during follow-up, a higher number of previous CDTI rounds increased the odds of having a post-treatment mf density >20% of the pre-treatment value (p= 0.006). In conclusion, the high onchocerciasis transmission in the study sites may be due to initially high infection intensity in some individuals. Whether the decreasing effect of ivermectin with increasing years of CDTI results from sub-optimal response mechanisms warrants further research. | Notes: | Colebunders, R (corresponding author), Univ Antwerp, Global Hlth Inst, Doornstr 331, B-2610 Antwerp, Belgium.; Colebunders, R (corresponding author), Univ Antwerp, Gouverneur Kinsbergenctr, Global Hlth Inst, Doornstr 331, B-2610 Antwerp, Belgium. alfred.dusabimana@uantwerpen.be; danbhwana@yahoo.com; Stephen.Jada@amref.org; b.mmbando@yahoo.com; an.hotterbeekx@uantwerpen.be; floritepage@yahoo.fr; Michel.MandroNdahura@studentuantwerpen.be; JosephNelson.SieweFodjo@uantwerpen.be; Steven.Abrams@uantwerpen.be; robert.colebunders@uantwerpen.be |
Other: | Colebunders, R (corresponding author), Univ Antwerp, Gouverneur Kinsbergenctr, Global Hlth Inst, Doornstr 331, B-2610 Antwerp, Belgium. alfred.dusabimana@uantwerpen.be; danbhwana@yahoo.com; Stephen.Jada@amref.org; b.mmbando@yahoo.com; an.hotterbeekx@uantwerpen.be; floritepage@yahoo.fr; Michel.MandroNdahura@studentuantwerpen.be; JosephNelson.SieweFodjo@uantwerpen.be; Steven.Abrams@uantwerpen.be; robert.colebunders@uantwerpen.be | Keywords: | ivermectin;sub-optimal response;onchocerciasis;Onchocerca volvulus;epilepsy | Document URI: | http://hdl.handle.net/1942/32979 | e-ISSN: | 2076-0817 | DOI: | 10.3390/pathogens9080617 | ISI #: | WOS:000567326300001 | Rights: | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
pathogens-09-00617.pdf | Published version | 537.32 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
7
checked on Oct 13, 2024
Page view(s)
40
checked on Sep 6, 2022
Download(s)
12
checked on Sep 6, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.