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http://hdl.handle.net/1942/33046| Title: | DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter | Authors: | WANG, Congrong PLUSQUIN, Michelle Ghantous, Akram Herceg, Zdenko ALFANO, Rossella COX, Bianca NAWROT, Tim |
Issue Date: | 2020 | Publisher: | Springer Science and Business Media {LLC} | Source: | Environmental Health, 19 (1) (Art N° 129) | Abstract: | Background: The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM 2.5 exposure and newborn DNA methylation of the IGF2/H19. | Keywords: | Air pollution;DLNM;Factor analysis;Fetal growth;Gestation;H19;IGF2;Imprinted genes;Methylation;Newborn;PM2.5 | Document URI: | http://hdl.handle.net/1942/33046 | e-ISSN: | 1476-069X | DOI: | 10.1186/s12940-020-00677-9 | ISI #: | 000597940700001 | Rights: | The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
| Appears in Collections: | Research publications |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| s12940-020-00677-9.pdf | Published version | 1.27 MB | Adobe PDF | View/Open |
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