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http://hdl.handle.net/1942/33065
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DC Field | Value | Language |
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dc.contributor.author | Berkvens, Jessica | - |
dc.contributor.author | Majoie, Marian | - |
dc.contributor.author | Mergler, Sandra | - |
dc.contributor.author | Beerhorst, Kim | - |
dc.contributor.author | Verschuure, Pauline | - |
dc.contributor.author | Tan, In | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.date.accessioned | 2021-01-07T13:08:03Z | - |
dc.date.available | 2021-01-07T13:08:03Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-01-06T14:06:04Z | - |
dc.identifier.citation | EPILEPSY RESEARCH, 167 (Art N° 106461) | - |
dc.identifier.uri | http://hdl.handle.net/1942/33065 | - |
dc.description.abstract | Objective: The main objective of this cohort study is to determine the prevalence and incidence of morphometric vertebral fractures (VFs) over 7 years follow-up, in institutionalized adults with refractory epilepsy and intellectual disability (ID). Methods: Dual-energy X-ray Absorptiometry (DXA) and Vertebral Fracture Assessment (VFA) were performed in 2009 and 2016. Vertebrae T4-L4 were assessed using quantitative morphometry. Severity of VFs was graded as 1 (mild; 20-25% reduction in height), 2 (moderate; 25-40% reduction) or 3 (severe; >40% reduction) according to the method described by Genant. Prevalent VFs were analyzed at baseline. VFs (grade 1, 2 or 3) present at follow-up, but not at baseline, were considered new VFs. Worsening VFs were defined as VFs with at least one grade deterioration at follow-up, compared to baseline (grade 1 to 2 or 3, or grade 2 to 3). Patients were treated with anti-osteoporosis treatment according to the Dutch guideline. Results: Baseline and follow-up DXA and VFA could be obtained in 141 patients (87 male) aged between 18-79 years old (mean 44.8 +/- 15.7). At baseline, 56 patients had at least one prevalent VF. Patients with a prevalent VF were significantly older than patients without (49.2 +/- 13.7 vs 41.9 +/- 16.4, p < .01). After 7 years follow-up, 38 new VFs occurred in 27 patients and 15 patients had a worsening VF, leading to an overall cumulative incidence of 27.0%. VF incidence was significantly higher in patients with at least one prevalent VF at baseline (48.2% vs 12.9%, respectively, p < .01) compared to no VF. Significance: In adults with refractory epilepsy VFA is challenging, due to physical and behavioral aspects, resulting in a substantial proportion of unevaluable vertebrae and scans. Nevertheless, 40% of the patients had a VF at baseline and after 7 years follow-up, 27% had at least one new and/or worsening VF despite adequate anti-osteoporosis treatment. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject.other | Anti-epileptic drugs (AEDs) | - |
dc.subject.other | Bisphosphonates | - |
dc.subject.other | Bone mineral density (BMD) | - |
dc.subject.other | Dual-energy X-ray absorptiometry (DXA) | - |
dc.subject.other | Osteoporosis | - |
dc.subject.other | Vertebral Fractures Assessment (VFA) | - |
dc.title | Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 167 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Berkvens, J (corresponding author), Epilepsy Ctr Kempenhaeghe, Dept Residential Care, POB 61, NL-5590 AB Heeze, Netherlands. | - |
dc.description.notes | BerkvensJ@Kempenhaeghe.nl | - |
dc.description.other | Berkvens, J (corresponding author), Epilepsy Ctr Kempenhaeghe, Dept Residential Care, POB 61, NL-5590 AB Heeze, Netherlands. BerkvensJ@Kempenhaeghe.nl | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 106461 | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2020.106461 | - |
dc.identifier.isi | WOS:000587830900028 | - |
dc.contributor.orcid | Tan, In/0000-0002-0496-8209; Berkvens, Jessica/0000-0002-6520-312X; | - |
dc.contributor.orcid | Majoie, Marian/0000-0003-0579-8122; van den Bergh, | - |
dc.contributor.orcid | Joop/0000-0003-3984-2232 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Berkvens, Jessica; Tan, In] Epilepsy Ctr Kempenhaeghe, Dept Residential Care, POB 61, NL-5590 AB Heeze, Netherlands. | - |
local.description.affiliation | [Majoie, Marian] Maastricht Univ, Acad Ctr Epileptol Kempenhaeghe, Dept Neurol, Med Ctr, Heeze, Netherlands. | - |
local.description.affiliation | [Majoie, Marian] Maastricht Univ, Acad Ctr Epileptol Kempenhaeghe, Dept Neurol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Majoie, Marian] Maastricht Univ, MHeNs Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Majoie, Marian] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Hlth Profess Educ, Maastricht, Netherlands. | - |
local.description.affiliation | [Mergler, Sandra] Care & Serv Ctr People Intellectual Disabil, Med Dept ASVZ, Sliedrecht, Netherlands. | - |
local.description.affiliation | [Mergler, Sandra] Erasmus MC, Dept Gen Practice & Intellectual Disabil Med, Rotterdam, Netherlands. | - |
local.description.affiliation | [Beerhorst, Kim] Zuyderland Med Ctr, Dept Neurol, Heerlen, Netherlands. | - |
local.description.affiliation | [Verschuure, Pauline] Epilepsy Ctr Kempenhaeghe, Lab Clin Chem & Pharmacol, Heeze, Netherlands. | - |
local.description.affiliation | [van den Bergh, Joop] VieCuri Med Ctr, Dept Internal Med, Subdiv Endocrinol, Venlo, Netherlands. | - |
local.description.affiliation | [van den Bergh, Joop] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Internal Med, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [van den Bergh, Joop] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Berkvens, Jessica; Majoie, Marian; Mergler, Sandra; Beerhorst, Kim; Verschuure, Pauline; Tan, In & VAN DEN BERGH, Joop (2020) Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability. In: EPILEPSY RESEARCH, 167 (Art N° 106461). | - |
item.fulltext | With Fulltext | - |
item.contributor | Berkvens, Jessica | - |
item.contributor | Majoie, Marian | - |
item.contributor | Mergler, Sandra | - |
item.contributor | Beerhorst, Kim | - |
item.contributor | Verschuure, Pauline | - |
item.contributor | Tan, In | - |
item.contributor | VAN DEN BERGH, Joop | - |
crisitem.journal.issn | 0920-1211 | - |
crisitem.journal.eissn | 1872-6844 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0920121120305118-main.pdf Restricted Access | Published version | 581.08 kB | Adobe PDF | View/Open Request a copy |
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