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Title: | A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study | Authors: | Vanassche, T. Engelen, M. M. Van Thillo, Q. Wauters, J. Gunst, J. Wouters, C. Vandenbriele, C. Rex, S. LIESENBORGHS, L. Wilmer, A. Meersseman, P. Van den Berghe, G. Dauwe, D. VERBEKE, Geert THOMEER, Michiel Fivez, T. MESOTTEN, Dieter RUTTENS, David Heytens, L. Dapper, I. Tuyls, S. De Tavernier, B. Verhamme, P. |
Issue Date: | 2020 | Publisher: | BMC | Source: | Trials, 21 (1) (Art N° 1005) | Abstract: | Background: The peak of the global COVID-19 pandemic has not yet been reached, and many countries face the prospect of a second wave of infections before effective vaccinations will be available. After an initial phase of viral replication, some patients develop a second illness phase in which the host thrombotic and inflammatory responses seem to drive complications. Severe COVID-19 disease is linked to high mortality, hyperinflammation, and a remarkably high incidence of thrombotic events. We hypothesize a crucial pathophysiological role for the contact pathway of coagulation and the kallikrein-bradykinin pathway. Therefore, drugs that modulate this excessive thromboinflammatory response should be investigated in severe COVID-19. | Keywords: | COVID-19;SARS-CoV-2;Low molecular weight heparins;Aprotinin;Anakinra;Thromboinflammatory response;Thrombosis;Inflammation | Document URI: | http://hdl.handle.net/1942/33080 | e-ISSN: | 1745-6215 | DOI: | 10.1186/s13063-020-04878-y | ISI #: | WOS:000600118700001 | Rights: | The Author(s). 2020, corrected publication 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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s13063-020-04878-y.pdf | Published version | 1.34 MB | Adobe PDF | View/Open |
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