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http://hdl.handle.net/1942/33155
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DC Field | Value | Language |
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dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | ABRAMS, Steven | - |
dc.contributor.author | HENS, Niel | - |
dc.contributor.author | Beutels, Philippe | - |
dc.contributor.author | FAES, Christel | - |
dc.contributor.author | VERBEKE, Geert | - |
dc.contributor.author | Van Damme, Pierre | - |
dc.contributor.author | Goossens, Herman | - |
dc.contributor.author | NEYENS, Thomas | - |
dc.contributor.author | HERZOG, Sereina | - |
dc.contributor.author | Theeten, Heidi | - |
dc.contributor.author | Pepermans, Koen | - |
dc.contributor.author | Abad, Ariel Alonso | - |
dc.contributor.author | VAN KEILEGOM, Ingrid | - |
dc.contributor.author | Speybroeck, Niko | - |
dc.contributor.author | LEGRAND, Catherine | - |
dc.contributor.author | De Buyser, Stefanie | - |
dc.contributor.author | Hulstaert, Frank | - |
dc.date.accessioned | 2021-01-24T13:10:33Z | - |
dc.date.available | 2021-01-24T13:10:33Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-01-21T08:56:58Z | - |
dc.identifier.citation | Contemporary Clinical Trials, 99 (Art N° 106189) | - |
dc.identifier.uri | http://hdl.handle.net/1942/33155 | - |
dc.description.abstract | Starting from historic reflections, the current SARS-CoV-2 induced COVID-19 pandemic is examined from various perspectives, in terms of what it implies for the implementation of non-pharmaceutical interventions, the modeling and monitoring of the epidemic, the development of early-warning systems, the study of mortality, prevalence estimation, diagnostic and serological testing, vaccine development, and ultimately clinical trials. Emphasis is placed on how the pandemic had led to unprecedented speed in methodological and clinical development, the pitfalls thereof, but also the opportunities that it engenders for national and international collaboration, and how it has simplified and sped up procedures. We also study the impact of the pandemic on clinical trials in other indications. We note that it has placed biostatistics, epidemiology, virology, infectiology, and vaccinology, and related fields in the spotlight in an unprecedented way, implying great opportunities, but also the need to communicate effectively, often amidst controversy. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Antiviral therapy | - |
dc.subject.other | Diagnostic testing | - |
dc.subject.other | Infection fatality rate | - |
dc.subject.other | Mortality | - |
dc.subject.other | Non-pharmaceutical intervention | - |
dc.subject.other | Nowcasting | - |
dc.subject.other | Prevalence | - |
dc.subject.other | Mathematical epidemiology | - |
dc.subject.other | Mathematical modeling | - |
dc.subject.other | Vaccine development | - |
dc.subject.other | Pragmatic trials | - |
dc.subject.other | Factorial designs | - |
dc.subject.other | Platform trials | - |
dc.subject.other | Data sharing | - |
dc.title | Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 99 | - |
local.format.pages | 17 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. | - |
dc.description.notes | marc.buyse@iddi.com | - |
dc.description.other | Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. marc.buyse@iddi.com | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 106189 | - |
dc.identifier.doi | 10.1016/j.cct.2020.106189 | - |
dc.identifier.isi | WOS:000599523300015 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Molenberghs, Geert; Buyse, Marc; Abrams, Steven; Hens, Niel; Faes, Christel; Verbeke, Geert; Neyens, Thomas] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. | - |
local.description.affiliation | [Molenberghs, Geert; Verbeke, Geert; Neyens, Thomas; Abad, Ariel Alonso] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. | - |
local.description.affiliation | [Buyse, Marc] Int Drug Dev Inst, Ceroux Mousty, Belgium. | - |
local.description.affiliation | [Buyse, Marc] CluePoints, Louvain La Neuve, Belgium. | - |
local.description.affiliation | [Abrams, Steven] Univ Antwerp, Global Hlth Inst, Dept Epidemiol & Social Med, Antwerp, Belgium. | - |
local.description.affiliation | [Hens, Niel; Beutels, Philippe; Van Damme, Pierre; Herzog, Sereina; Theeten, Heidi; Pepermans, Koen] Univ Antwerp, Ctr Hlth Econ Res & Modelling Infect Dis, Antwerp, Belgium. | - |
local.description.affiliation | [Hens, Niel; Beutels, Philippe; Van Damme, Pierre; Herzog, Sereina; Theeten, Heidi; Pepermans, Koen] Univ Antwerp, Vaccine & Infect Dis Inst, Antwerp, Belgium. | - |
local.description.affiliation | [Goossens, Herman] Univ Antwerp, Med Microbiol, Antwerp, Belgium. | - |
local.description.affiliation | [Van Keilegom, Ingrid] Katholieke Univ Leuven, Fac Econ & Business, ORSTAT, Leuven, Belgium. | - |
local.description.affiliation | [Speybroeck, Niko] UC Louvain, Inst Hlth & Soc, Louvain, Belgium. | - |
local.description.affiliation | [Legrand, Catherine] UC Louvain, Inst Stat Biostat & Actuarial Sci, Louvain, Belgium. | - |
local.description.affiliation | [De Buyser, Stefanie] Univ Ghent, Ghent, Belgium. | - |
local.description.affiliation | [Hulstaert, Frank] Belgian Hlth Care Knowledge Ctr KCE, Brussels, Belgium. | - |
item.fulltext | With Fulltext | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | BUYSE, Marc | - |
item.contributor | ABRAMS, Steven | - |
item.contributor | HENS, Niel | - |
item.contributor | Beutels, Philippe | - |
item.contributor | FAES, Christel | - |
item.contributor | VERBEKE, Geert | - |
item.contributor | Van Damme, Pierre | - |
item.contributor | Goossens, Herman | - |
item.contributor | NEYENS, Thomas | - |
item.contributor | HERZOG, Sereina | - |
item.contributor | Theeten, Heidi | - |
item.contributor | Pepermans, Koen | - |
item.contributor | Abad, Ariel Alonso | - |
item.contributor | VAN KEILEGOM, Ingrid | - |
item.contributor | Speybroeck, Niko | - |
item.contributor | LEGRAND, Catherine | - |
item.contributor | De Buyser, Stefanie | - |
item.contributor | Hulstaert, Frank | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2022 | - |
item.fullcitation | MOLENBERGHS, Geert; BUYSE, Marc; ABRAMS, Steven; HENS, Niel; Beutels, Philippe; FAES, Christel; VERBEKE, Geert; Van Damme, Pierre; Goossens, Herman; NEYENS, Thomas; HERZOG, Sereina; Theeten, Heidi; Pepermans, Koen; Abad, Ariel Alonso; VAN KEILEGOM, Ingrid; Speybroeck, Niko; LEGRAND, Catherine; De Buyser, Stefanie & Hulstaert, Frank (2020) Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country. In: Contemporary Clinical Trials, 99 (Art N° 106189). | - |
crisitem.journal.issn | 1551-7144 | - |
crisitem.journal.eissn | 1559-2030 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S1551714420302676-main.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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