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Title: | Age-related GABAergic differences in the primary sensorimotor cortex: A multimodal approach combining PET, MRS and TMS | Authors: | CUYPERS, Koen HEHL, Melina van Aalst, June Chalavi, Sima Mikkelsen, Mark Van Laere, Koen Dupont, Patrick Mantini, Dante Swinnen, Stephan P. |
Issue Date: | 2021 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | NeuroImage (Orlando, Fla. Print), 226 (Art N° 117536) | Abstract: | Healthy aging is associated with mechanistic changes in gamma-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter in the human brain. While previous work mainly focused on magnetic resonance spectroscopy (MRS)-based GABA + levels and transcranial magnetic stimulation (TMS)-based GABA A receptor (GABA A R) activity in the primary sensorimotor (SM1) cortex, the aim of the current study was to identify age-related differences in positron emission tomography (PET)-based GABA A R availability and its relationship with GABA + levels (i.e. GABA with the contribution of macromolecules) and GABA A R activity. For this purpose, fifteen young (aged 20-28 years) and fifteen older (aged 65-80 years) participants were recruited. PET and MRS images were acquired using simultaneous time-of-flight PET/MR to evaluate age-related differences in GABA A R availability (distribution volume ratio with pons as reference region) and GABA + levels. TMS was applied to identify age-related differences in GABA A R activity by measuring short-interval intracortical inhibition (SICI). Whereas GABA A R availability was significantly higher in the SM cortex of older as compared to young adults (18.5%), there were neither age-related differences in GABA + levels nor SICI. A correlation analysis revealed no significant associations between GABA A R availability, GABA A R activity and GABA + levels. Although the exact mechanisms need to be further elucidated, it is possible that a higher GABA A R availability in older adults is a compensatory mechanism to ensure optimal inhibitory functionality during the aging process. | Keywords: | Aging;GABA;PET;MRS;TMS | Document URI: | http://hdl.handle.net/1942/33221 | ISSN: | 1053-8119 | e-ISSN: | 1095-9572 | DOI: | 10.1016/j.neuroimage.2020.117536 | ISI #: | 000608035900015 | Rights: | 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.0-S1053811920310211-main.pdf | Published version | 1.42 MB | Adobe PDF | View/Open |
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