Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/33233
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schonkeren, Simone L | - |
dc.contributor.author | THIJSSEN, Meike | - |
dc.contributor.author | Vaes, Nathalie | - |
dc.contributor.author | BOESMANS, Werend | - |
dc.contributor.author | Melotte, Veerle | - |
dc.date.accessioned | 2021-01-29T13:44:07Z | - |
dc.date.available | 2021-01-29T13:44:07Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-01-25T14:03:00Z | - |
dc.identifier.citation | Cancers (Basel), 13 (1) (Art N° 152) | - |
dc.identifier.uri | http://hdl.handle.net/1942/33233 | - |
dc.description.abstract | The role of the nervous system as a contributor in the tumor microenvironment has been recognized in different cancer types, including colorectal cancer (CRC). The gastrointestinal tract is a highly innervated organ system, which is not only innervated by the autonomic nervous system, but also contains an extensive nervous system of its own; the enteric nervous system (ENS). The ENS is important for gut function and homeostasis by regulating processes such as fluid absorption, blood flow, and gut motility. Dysfunction of the ENS has been linked with multiple gastrointestinal diseases, such as Hirschsprung disease and inflammatory bowel disease, and even with neurodegenerative disorders. How the extrinsic and intrinsic innervation of the gut contributes to CRC is not fully understood, although a mutual relationship between cancer cells and nerves has been described. Nerves enhance cancer progression through the secretion of neurotransmitters and neuropeptides, and cancer cells are capable of stimulating nerve growth. This review summarizes and discusses the nervous system innervation of the gastrointestinal tract and how it can influence carcinogenesis, and vice versa. Lastly, the therapeutic potential of these novel insights is discussed. | - |
dc.description.sponsorship | This research was funded by The Netherlands Organisation for Scientific Research (NWO) Veni grant, grant number 016.186.124 (V.M.), by a BOF-mandate at Hasselt University (BSFWBIOMED) (M.S.T.), and by a Kootstra talent fellowship at Maastricht University (N.V.). | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) | - |
dc.subject.other | colorectal cancer | - |
dc.subject.other | enteric nervous system | - |
dc.subject.other | glia | - |
dc.subject.other | innervation | - |
dc.subject.other | nerves | - |
dc.subject.other | neurons | - |
dc.subject.other | peripheral nervous system | - |
dc.subject.other | tumor microenvironment | - |
dc.title | The Emerging Role of Nerves and Glia in Colorectal Cancer | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 13 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 152 | - |
dc.identifier.doi | 10.3390/cancers13010152 | - |
dc.identifier.pmid | 33466373 | - |
dc.identifier.isi | 000605821100001 | - |
dc.identifier.eissn | 2072-6694 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fullcitation | Schonkeren, Simone L; THIJSSEN, Meike; Vaes, Nathalie; BOESMANS, Werend & Melotte, Veerle (2021) The Emerging Role of Nerves and Glia in Colorectal Cancer. In: Cancers (Basel), 13 (1) (Art N° 152). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
item.contributor | Schonkeren, Simone L | - |
item.contributor | THIJSSEN, Meike | - |
item.contributor | Vaes, Nathalie | - |
item.contributor | BOESMANS, Werend | - |
item.contributor | Melotte, Veerle | - |
item.accessRights | Open Access | - |
crisitem.journal.eissn | 2072-6694 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
cancers-13-00152-v2.pdf | Published version | 600.16 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.