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http://hdl.handle.net/1942/33235
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DC Field | Value | Language |
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dc.contributor.author | Mailleux, Lisa | - |
dc.contributor.author | Simon-Martinez, Cristina | - |
dc.contributor.author | Radwan, Ahmed | - |
dc.contributor.author | Blommaert, Jeroen | - |
dc.contributor.author | Gooijers, Jolien | - |
dc.contributor.author | Wenderoth, Nicole | - |
dc.contributor.author | KLINGELS, Katrijn | - |
dc.contributor.author | Ortibus, Els | - |
dc.contributor.author | Sunaert, Stefan | - |
dc.contributor.author | Feys, Hilde | - |
dc.date.accessioned | 2021-01-29T14:09:35Z | - |
dc.date.available | 2021-01-29T14:09:35Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-01-26T15:57:40Z | - |
dc.identifier.citation | Brain Structure & Function, 225 (5) , p. 1495 -1509 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33235 | - |
dc.description.abstract | This study explored the role of lesion timing (periventricular white matter versus cortical and deep grey matter lesions) and type of corticospinal tract (CST) wiring pattern (contralateral, bilateral, ipsilateral) on white matter characteristics of the CST, medial lemniscus, superior thalamic radiations and sensorimotor transcallosal fibers in children with unilateral cerebral palsy (CP), and examined the association with upper limb function. Thirty-four children (mean age 10 years 7 months ± 2 years 3 months) with unilateral CP underwent a comprehensive upper limb evaluation and diffusion weighted imaging (75 directions, b value 2800). Streamline count, fractional anisotropy and mean diffusivity were extracted from the targeted tracts and asymmetry indices were additionally calculated. Transcranial magnetic stimulation was applied to assess the CST wiring pattern. Results showed a more damaged CST in children with cortical and deep grey matter lesions (N = 10) and ipsilateral CST projections (N = 11) compared to children with periventricular white matter lesions (N = 24; p < 0.02) and contralateral CST projections (N = 9; p < 0.025), respectively. Moderate to high correlations were found between diffusion metrics of the targeted tracts and upper limb function (r = 0.45-0.72; p < 0.01). Asymmetry indices of the CST and sensory tracts could best explain bimanual performance (74%, p < 0.0001) and unimanual capacity (50%, p = 0.004). Adding lesion timing and CST wiring pattern did not further improve the model of bimanual performance, while for unimanual capacity lesion timing was additionally retained (58%, p = 0.0002). These results contribute to a better understanding of the underlying neuropathology of upper limb function in children with unilateral CP and point towards a clinical potential of tractography. | - |
dc.description.sponsorship | Acknowledgements We acknowledge all parents and their children for their participation in this study. We also thank Jasmine Hoskens for her assistance during the assessments. Lastly, we would like to acknowledge, dr. Annouschka Laenen and dr. Anna Ivanova, from the Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven for their advice regarding the statistical analyses. Funding This study was funded by the Fund Scientifc Research Flanders (FWO project, Grant G087213N), by the Special Research Fund, KU Leuven (Grant OT/14/127). | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.rights | Springer-Verlag GmbH Germany, part of Springer Nature 2020 | - |
dc.subject.other | Brain injuries | - |
dc.subject.other | Diffusion magnetic resonance imaging | - |
dc.subject.other | Transcranial magnetic stimulation | - |
dc.subject.other | Unilateral cerebral palsy | - |
dc.subject.other | Upper extremity | - |
dc.title | White matter characteristics of motor, sensory and interhemispheric tracts underlying impaired upper limb function in children with unilateral cerebral palsy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1509 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1495 | - |
dc.identifier.volume | 225 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s00429-020-02070-1 | - |
dc.identifier.pmid | 32318818 | - |
dc.identifier.isi | WOS:000528504900001 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fullcitation | Mailleux, Lisa; Simon-Martinez, Cristina; Radwan, Ahmed; Blommaert, Jeroen; Gooijers, Jolien; Wenderoth, Nicole; KLINGELS, Katrijn; Ortibus, Els; Sunaert, Stefan & Feys, Hilde (2020) White matter characteristics of motor, sensory and interhemispheric tracts underlying impaired upper limb function in children with unilateral cerebral palsy. In: Brain Structure & Function, 225 (5) , p. 1495 -1509. | - |
item.contributor | Mailleux, Lisa | - |
item.contributor | Simon-Martinez, Cristina | - |
item.contributor | Radwan, Ahmed | - |
item.contributor | Blommaert, Jeroen | - |
item.contributor | Gooijers, Jolien | - |
item.contributor | Wenderoth, Nicole | - |
item.contributor | KLINGELS, Katrijn | - |
item.contributor | Ortibus, Els | - |
item.contributor | Sunaert, Stefan | - |
item.contributor | Feys, Hilde | - |
item.validation | ecoom 2021 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1863-2653 | - |
crisitem.journal.eissn | 1863-2661 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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PostPrint.pdf | Peer-reviewed author version | 860.6 kB | Adobe PDF | View/Open |
Mailleux2020_Article_WhiteMatterCharacteristicsOfMo.pdf Restricted Access | Published version | 1.3 MB | Adobe PDF | View/Open Request a copy |
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