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Title: | Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19 | Authors: | Machado, Felipe V. C. Meys, Roy Delbressine, Jeannet M. Vaes, Anouk W. Goërtz, Yvonne M. J. VAN HERCK, Maarten Houben-Wilke, Sarah Boon, Gudula J. A. M. Barco, Stefano BURTIN, Chris van ’t Hul, Alex Posthuma, Rein Franssen, Frits M. E. Spies, Yvonne Vijlbrief, Herman Pitta, Fabio Rezek, Spencer A. Janssen, Daisy J. A. Siegerink, Bob Klok, Frederikus A. SPRUIT, Martijn A. |
Issue Date: | 2021 | Publisher: | Springer Nature | Source: | Health and Quality of Life Outcomes, 19 (Art N° 40) | Abstract: | Background: An increasing number of subjects are recovering from COVID-19, raising the need for tools to adequately assess the course of the disease and its impact on functional status. We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19. Methods: Adult subjects with confirmed and presumed COVID-19, who were members of an online panel and two Facebook groups for subjects with COVID-19 with persistent symptoms, completed an online survey after the onset of infection-related symptoms. The number and intensity of symptoms were evaluated with the Utrecht Symptom Diary, health-related quality of life (HrQoL) with the 5-level EQ-5D questionnaire, impairment in work and activities with the Work Productivity and Activity Impairment questionnaire and functional status with the PCFS Scale. Results: 1939 subjects were included in the analyses (85% women, 95% non-hospitalized during infection) about 3 months after the onset of infection-related symptoms. Subjects classified as experiencing ‘slight’, ‘moderate’ and ‘severe’ functional limitations presented a gradual increase in the number/intensity of symptoms, reduction of HrQoL and impairment in work and usual activities. No differences were found regarding the number and intensity of symptoms, HrQoL and impairment in work and usual activities between subjects classified as experiencing ‘negligible’ and ‘no’ functional limitations. We found weak-to-strong statistical associations between functional status and all domains of HrQoL (r: 0.233–0.661). Notably, the strongest association found was with the ‘usual activities’ domain of the 5-level EQ-5D questionnaire. Conclusion: We demonstrated the construct validity of the PCFS Scale in highly-symptomatic adult subjects with confirmed and presumed COVID-19, 3 months after the onset of symptoms. | Keywords: | SARS-CoV-2;Functional status;Symptoms;Quality of life | Document URI: | http://hdl.handle.net/1942/33312 | e-ISSN: | 1477-7525 | DOI: | 10.1186/s12955-021-01691-2 | ISI #: | 000614413100001 | Datasets of the publication: | NTR NL8705 | Rights: | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Machado et al 2021 - Health and Quality of Life outcomes - COVID-19 and PCFS scale.pdf | Published version | 1.26 MB | Adobe PDF | View/Open |
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