Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33456
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dc.contributor.authorVos, L. M.-
dc.contributor.authorBRUYNDONCKX, Robin-
dc.contributor.authorZuithoff, N. P. A.-
dc.contributor.authorLittle, P.-
dc.contributor.authorOosterheert, J. J.-
dc.contributor.authorBroekhuizen, B. D. L.-
dc.contributor.authorLammens, C.-
dc.contributor.authorLoens, K.-
dc.contributor.authorViveen, M.-
dc.contributor.authorButler, C. C.-
dc.contributor.authorCrook, D.-
dc.contributor.authorZlateva, K.-
dc.contributor.authorGoossens, H.-
dc.contributor.authorClaas, E. C. J.-
dc.contributor.authorIEVEN, Magda-
dc.contributor.authorVan Loon, A. M.-
dc.contributor.authorVerheij, T. J. M.-
dc.contributor.authorCoenjaerts, F. E. J.-
dc.date.accessioned2021-02-16T08:09:54Z-
dc.date.available2021-02-16T08:09:54Z-
dc.date.issued2021-
dc.date.submitted2021-02-02T14:08:24Z-
dc.identifier.citationCLINICAL MICROBIOLOGY AND INFECTION, 27 (1) , p. 96 -104-
dc.identifier.urihttp://hdl.handle.net/1942/33456-
dc.description.abstractObjectives: This study determined associations between respiratory viruses and subsequent illness course in primary care adult patients presenting with acute cough and/or suspected lower respiratory tract infection. Methods: A prospective European primary care study recruited adults with symptoms of lower respiratory tract infection between November 2007 and April 2010. Real-time in-house polymerase chain reaction (PCR) was performed to test for six common respiratory viruses. In this secondary analysis, symptom severity (scored 1 = no problem, 2 = mild, 3 = moderate, 4 = severe) and symptom duration were compared between groups with different viral aetiologies using regression and Cox proportional hazard models, respectively. Additionally, associations between baseline viral load (cycle threshold (Ct) value) and illness course were assessed. Results: The PCR tested positive for a common respiratory virus in 1354 of the 2957 (45.8%) included patients. The overall mean symptom score at presentation was 2.09 (95% confidence interval (CI) 2.07-2.11) and the median duration until resolution of moderately bad or severe symptoms was 8.70 days (interquartile range 4.50-11.00). Patients with influenza virus, human metapneumovirus (hMPV), respiratory syncytial virus (RSV), coronavirus (CoV) or rhinovirus had a significantly higher symptom score than patients with no virus isolated (0.07-0.25 points or 2.3-8.3% higher symptom score). Time to symptom resolution was longer in RSV infections (adjusted hazard ratio (AHR) 0.80, 95% CI 0.65-0.96) and hMPV infections (AHR 0.77, 95% CI 0.62-0.94) than in infections with no virus isolated. Overall, baseline viral load was associated with symptom severity (difference 0.11, 95% CI 0.06-0.16 per 10 cycles decrease in Ct value), but not with symptom duration. Conclusions: In healthy, working adults from the general community presenting at the general practitioner with acute cough and/or suspected lower respiratory tract infection other than influenza impose an illness burden comparable to influenza. Hence, the public health focus for viral respiratory tract infections should be broadened. (C) 2020 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.-
dc.description.sponsorshipThe authors declare that they have no conflicts of interest. The study was part of the European Commission Framework Programme 6 (FP6) funded Network of Excellence GRACE, grant number 518226. Orion Diagnostics provided the QuikRead instruments and kits for this study. The study sponsors played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.-
dc.language.isoen-
dc.publisherELSEVIER SCI LTD-
dc.rights2020 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.-
dc.subject.otherDisease burden-
dc.subject.otherlower respiratory tract infection-
dc.subject.otherprimary healthcare-
dc.subject.otherpublic health-
dc.subject.otherrespiratory tract infection-
dc.subject.otherrespiratory virus-
dc.subject.othersymptom duration-
dc.subject.othersymptom severity-
dc.titleLower respiratory tract infection in the community: associations between viral aetiology and illness course-
dc.typeJournal Contribution-
dc.identifier.epage104-
dc.identifier.issue1-
dc.identifier.spage96-
dc.identifier.volume27-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notesVos, LM (corresponding author), Univ Utrecht, Univ Med Ctr Utrecht, Dept Infect Dis, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.-
dc.description.notesl.m.vos-6@umcutrecht.nl-
dc.description.otherVos, LM (corresponding author), Univ Utrecht, Univ Med Ctr Utrecht, Dept Infect Dis, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands. l.m.vos-6@umcutrecht.nl-
local.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1016/j.cmi.2020.03.023-
dc.identifier.isiWOS:000600577900018-
dc.contributor.orcidLittle, Paul/0000-0003-3664-1873; Butler,-
dc.contributor.orcidChristopher/0000-0002-0102-3453-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Vos, L. M.; Oosterheert, J. J.] Univ Utrecht, Univ Med Ctr Utrecht, Dept Infect Dis, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.-
local.description.affiliation[Bruyndonckx, R.; Lammens, C.; Loens, K.; Goossens, H.; Ieven, M.] Univ Antwerp, Vaccine & Infect Dis Inst Vaxinfectio, Lab Med Microbiol, Antwerp, Belgium.-
local.description.affiliation[Bruyndonckx, R.; Goossens, H.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium.-
local.description.affiliation[Zuithoff, N. P. A.; Broekhuizen, B. D. L.; Verheij, T. J. M.] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.-
local.description.affiliation[Little, P.] Univ Southampton, Primary Care & Populat Sci Unit, Southampton, Hants, England.-
local.description.affiliation[Viveen, M.; Van Loon, A. M.; Coenjaerts, F. E. J.] Univ Utrecht, Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands.-
local.description.affiliation[Butler, C. C.] Cardiff Univ, Inst Primary Care & Publ Hlth, Cardiff, Wales.-
local.description.affiliation[Crook, D.] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.-
local.description.affiliation[Zlateva, K.; Claas, E. C. J.] Leiden Univ, Leiden Univ Med Ctr, Dept Med Microbiol, Leiden, Netherlands.-
local.uhasselt.internationalyes-
item.validationecoom 2022-
item.contributorVos, L. M.-
item.contributorBRUYNDONCKX, Robin-
item.contributorZuithoff, N. P. A.-
item.contributorLittle, P.-
item.contributorOosterheert, J. J.-
item.contributorBroekhuizen, B. D. L.-
item.contributorLammens, C.-
item.contributorLoens, K.-
item.contributorViveen, M.-
item.contributorButler, C. C.-
item.contributorCrook, D.-
item.contributorZlateva, K.-
item.contributorGoossens, H.-
item.contributorClaas, E. C. J.-
item.contributorIEVEN, Magda-
item.contributorVan Loon, A. M.-
item.contributorVerheij, T. J. M.-
item.contributorCoenjaerts, F. E. J.-
item.accessRightsOpen Access-
item.fullcitationVos, L. M.; BRUYNDONCKX, Robin; Zuithoff, N. P. A.; Little, P.; Oosterheert, J. J.; Broekhuizen, B. D. L.; Lammens, C.; Loens, K.; Viveen, M.; Butler, C. C.; Crook, D.; Zlateva, K.; Goossens, H.; Claas, E. C. J.; IEVEN, Magda; Van Loon, A. M.; Verheij, T. J. M. & Coenjaerts, F. E. J. (2021) Lower respiratory tract infection in the community: associations between viral aetiology and illness course. In: CLINICAL MICROBIOLOGY AND INFECTION, 27 (1) , p. 96 -104.-
item.fulltextWith Fulltext-
crisitem.journal.issn1198-743X-
crisitem.journal.eissn1469-0691-
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