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Title: | Positioning strictureplasty in the treatment of extensive Crohn’s disease ileitis: a comparative study with ileocecal resection | Authors: | Bislenghi, Gabriele FIEUWS, Steffen Wolthuis, Albert Vanbeckevoort, Dirk Ferrante, Marc Sabino, Joao Vermeire, Severine D'Hoore, Andre |
Issue Date: | 2021 | Publisher: | SPRINGER | Source: | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 36 (4) , p. 791-799 | Abstract: | Purpose The optimal surgical approach to extensive Crohn's disease (CD) terminal ileitis is debated. To date, no studies have directly compared the short- and long-term outcomes of modified side-to-side isoperistaltic strictureplasty over the valve (mSSIS) to traditional ileocecal resection. Methods A retrospective, observational, comparative study was conducted in consecutive CD patients operated for extensive involvement of the terminal ileum (>= 20 cm). Ninety-day postoperative morbidity was assessed using the comprehensive complication index (CCI). Surgical recurrence was defined as the need for any surgical intervention related to CD during the follow-up period. Endoscopic remission was defined as <= i2a, according to the modified Rutgeerts score. Deep remission was defined as the combination of endoscopic remission and absence of clinical symptoms. Perioperative factors related to clinical recurrence were evaluated. Results Eighty-seven patients were included (47 (54%) ileocecal resection and 40 (46%) mSSIS). Median follow-up was 56 (IQR 34.7-94.4) and 72 (IQR 48.3-87.2) months for resection and mSSIS, respectively (p < 0.001). No mortality occurred. Mean CCI was 9.1 vs 8.5 for ileocecal resection and mSSIS, respectively (p = 0.48). Throughout the follow-up, 8 patients in the resection group (17%) and 5 patients in the mSSIS group (12.5%) experienced surgical recurrence (p = 0.393). Thirty-seven (92.5%) of patients kept the mSSIS. No difference in deep remission was observed (41% vs 22.5%, p = 0.34). Conclusions Modified SSIS seems to be non-inferior in terms of safety, recurrence, and durability to traditional resections with the advantage of mitigating the risk of a short bowel syndrome. Larger prospective studies are required to confirm these findings. | Notes: | Bislenghi, G (corresponding author), Katholieke Univ Leuven, Dept Abdominal Surg, Univ Hosp Leuven, Leuven, Belgium. gabriele.bislenghi@uzleuven.be |
Other: | Bislenghi, G (corresponding author), Katholieke Univ Leuven, Dept Abdominal Surg, Univ Hosp Leuven, Leuven, Belgium. gabriele.bislenghi@uzleuven.be | Keywords: | Crohn's disease;Ileitis;Strictureplasty;Ileocecal resection;Recurrence | Document URI: | http://hdl.handle.net/1942/33476 | ISSN: | 0179-1958 | e-ISSN: | 1432-1262 | DOI: | 10.1007/s00384-021-03837-6 | ISI #: | 000609325700001 | Rights: | The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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