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Title: | Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy | Authors: | Van den Bergh, Bea R. H. van den Heuvel, Marion I. Lahti, Marius BRAEKEN, Marijke de Rooij, Susanne R. Entringer, Sonja Hoyer, Dirk Roseboom, Tessa Raikkonen, Katri King, Suzanne Schwab, Matthias |
Issue Date: | 2020 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 117 (SI) , p. 26 -64 | Abstract: | Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system. | Notes: | Van den Bergh, BRH (corresponding author), Univ Leuven, Res Grp Hlth Psychol, KU Leuven, Tiensestr 102, B-3000 Leuven, Belgium. bea.vandenbergh@kuleuven.be; m.vdnheuvel@wayne.edu; marius.lahti@helsinki.fi; marijke.braeken@uhasselt.be; s.r.derooij@amc.uva.nl; sonja.entringer@charite.de; dirk.hoyer@med.uni-jena.de; t.j.rooseboom@amc.uva.nl; katri.raikkonen@helsinki.fi; suzanne.king@mcgill.ca; matthias.schwab@med.uni-jena.de |
Other: | Van den Bergh, BRH (corresponding author), Univ Leuven, Res Grp Hlth Psychol, KU Leuven, Tiensestr 102, B-3000 Leuven, Belgium. bea.vandenbergh@kuleuven.be; m.vdnheuvel@wayne.edu; marius.lahti@helsinki.fi; marijke.braeken@uhasselt.be; s.r.derooij@amc.uva.nl; sonja.entringer@charite.de; dirk.hoyer@med.uni-jena.de; t.j.rooseboom@amc.uva.nl; katri.raikkonen@helsinki.fi; suzanne.king@mcgill.ca; matthias.schwab@med.uni-jena.de | Keywords: | Fetal programming;Maternal psychological distress;Life events;Disaster exposure;Objective stress;Anxiety;Pregnancy-specific anxiety;Depression;Autism;Attention deficit hyperactivity disorder (ADHD);Schizophrenia;Psychiatric disorders;Telomere biology;Epigenetics;Gut microbiome;Cortisol;HPA-axis;Heart rate variability;Autonomic nervous system;Event related potential (ERP);Functional magnetic resonance imaging (fMRI);Brain network connectivity;EEG | Document URI: | http://hdl.handle.net/1942/33489 | ISSN: | 0149-7634 | e-ISSN: | 1873-7528 | DOI: | 10.1016/j.neubiorev.2017.07.003 | ISI #: | WOS:000600573500005 | Rights: | 2017 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.pdf Restricted Access | Published version | 1.08 MB | Adobe PDF | View/Open Request a copy |
Van_den_Bergh_et_al_prenatal_developmental_origins_author_accepted_version.pdf | Peer-reviewed author version | 1.35 MB | Adobe PDF | View/Open |
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