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http://hdl.handle.net/1942/33491
Title: | Age-related differences of motor cortex plasticity in adults: A transcranial direct current stimulation study | Authors: | GHASEMIAN SHIRVAN, Ensiyeh Farnad, Leila Mosayebi-Samani, Mohsen VERSTRAELEN, Stefanie MEESEN, Raf Kuo, Min-Fang Nitsche, Michael A. |
Issue Date: | 2020 | Publisher: | ELSEVIER SCIENCE INC | Source: | Brain Stimulation, 13 (6) , p. 1588 -1599 | Abstract: | Background: Cognitive, and motor performance are reduced in aging, especially with respect to acquisition of new knowledge, which is associated with a neural plasticity decline. Animal models show a reduction of long-term potentiation, but not long-term depression, in higher age. Findings in humans are more heterogeneous, with some studies showing respective deficits, but others not, or mixed results, for plasticity induced by non-invasive brain stimulation. One reason for these heterogeneous results might be the inclusion of different age ranges in these studies. In addition, a systematic detailed comparison of the age-dependency of neural plasticity in humans is lacking so far. Objective: We aimed to explore age-dependent plasticity alterations in adults systematically by discerning between younger and older participants in our study. Methods: We recruited three different age groups (Young: 18-30, Pre-Elderly: 50-65, and Elderly: 66 -80 years). Anodal, cathodal, or sham transcranial direct current stimulation (tDCS) was applied over the primary motor cortex with 1 mA for 15 min to induce neuroplasticity. Cortical excitability was monitored by single-pulse transcranial magnetic stimulation as an index of plasticity. Results: For anodal tDCS, the results show a significant excitability enhancement, as compared to sham stimulation, for both, Young and the Pre-Elderly groups, while no LTP-like plasticity was obtained in the Elderly group by the applied stimulation protocol. Cathodal tDCS induced significant excitability-diminishing plasticity in all age groups. Conclusion: Our study provides further insight in age-related differences of plasticity in healthy humans, which are similar to those obtained in animal models. The decline of LTP-like plasticity in higher age could contribute to cognitive deficits observed in aging. (C) 2020 The Author(s). Published by Elsevier Inc. | Notes: | Nitsche, MA (corresponding author), Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosci, Dortmund, Germany. nitsche@ifado.de |
Other: | Nitsche, MA (corresponding author), Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosci, Dortmund, Germany. nitsche@ifado.de | Keywords: | Aging;Neuroplasticity;tDCS;MEP;TMS | Document URI: | http://hdl.handle.net/1942/33491 | ISSN: | 1935-861X | e-ISSN: | 1876-4754 | DOI: | 10.1016/j.brs.2020.09.004 | ISI #: | WOS:000597945200017 | Rights: | 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.0-S1935861X20302436-main.pdf | Published version | 1.23 MB | Adobe PDF | View/Open |
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