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http://hdl.handle.net/1942/33498
Title: | Fatty acid metabolism in the progression and resolution of CNS disorders | Authors: | BOGIE, Jeroen HAIDAR, Mansour Kooij, Gijs HENDRIKS, Jerome |
Issue Date: | 2020 | Publisher: | ELSEVIER | Source: | ADVANCED DRUG DELIVERY REVIEWS, 159 , p. 198 -213 | Abstract: | Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and level of fatty acids drive the initiation and progression of central nervous system (CNS) disorders such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Here, we provide an in-depth overview on the impact of the beta-oxidation, synthesis, desaturation, elongation, and peroxidation of fatty acids on the pathophysiology of these and other neurological disorders. Furthermore, we discuss the impact of individual fatty acids species, acquired through the diet or endogenously synthesized in mammals, on neuroinflammation, neurodegeneration, and CNS repair. The findings discussed in this review highlight the therapeutic potential of modulators of fatty acid metabolism and the fatty acid lipidome in CNS disorders, and underscore the diagnostic value of lipidome signatures in these diseases. (C) 2020 Published by Elsevier B.V. | Notes: | Hendriks, JJA (corresponding author), Hasselt Univ, Dept Neuroimmunol & Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. Jerome.hendriks@uhasselt.be |
Other: | Hendriks, JJA (corresponding author), Hasselt Univ, Dept Neuroimmunol & Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. Jerome.hendriks@uhasselt.be | Keywords: | Central nervous system;Lipids;Neuroinflammation;Immunometabolism;Neurodegeneration;Remyelination | Document URI: | http://hdl.handle.net/1942/33498 | ISSN: | 0169-409X | e-ISSN: | 1872-8294 | DOI: | 10.1016/j.addr.2020.01.004 | ISI #: | WOS:000600557400011 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Bogie et al 2019 Manuscript_.pdf | Peer-reviewed author version | 671.24 kB | Adobe PDF | View/Open |
1-s2.0-S0169409X20300065-main.pdf Restricted Access | Published version | 1.42 MB | Adobe PDF | View/Open Request a copy |
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