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Title: | Prenatal particulate air pollution exposure and expression of the miR-17/92 cluster in cord blood: Findings from the ENVIRONAGE birth cohort | Authors: | TSAMOU, Maria NAWROT, Tim CAROLLO, Riccardo Trippas, Ann-Julie Lefebvre, Wouter Vanpoucke, Charlotte VRIJENS, Karen |
Issue Date: | 2020 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | ENVIRONMENT INTERNATIONAL, 142 (Art N° 105860) | Abstract: | Background: Air pollution exposure during pregnancy is an important environmental health issue. Epigenetics mediate the effects of prenatal exposure and could increase disease predisposition in later life. The oncogenic miR-17/92 cluster is involved in normal development and disease. Objectives: Here, for the first time the potential prenatal effects of particulate matter with a diameter < 2.5 mu m (PM2.5) exposure on expression of the miR-17/92 cluster in cord blood are explored. Methods: In 370 mother-newborn pairs from the ENVIRONAGE birth cohort, expression of three members of the miR-17/92 cluster was measured in cord blood by qRT-PCR. Expression of C-MYC and CDKN1A, a cluster activator and a target gene, respectively, was also analyzed. Multivariable linear regression models were used to associate the relative m(i)RNA expression with prenatal PM2.5 exposure. Results: PM2.5 exposure averaged (10th-90th percentile) 11.7 (9.0-14.4) mu g/m(3) over the entire pregnancy. In cord blood, miR-17 and miR-20a showed a -45.0% (95%CI: -55.9 to -31.4, p < 0.0001) and a -33.7% (95%CI: -46.9 to -17.2, p = 0.0003), decrease in expression in association with first trimester PM2.5 exposure, and a -32.5% (95%CI: -45.6 to -16.3, p = 0.0004) and -23.3% (95%CI: -38.1 to -4.8, p = 0.02), respectively, decrease in expression in association with PM2.5 exposure during the entire pregnancy. In association with third trimester PM2.5 exposure, a reduction of -25.8% (95%CI: -40.2 to -8.0, p = 0.007) and -14.2% (95%CI: -27.7 to 1.9, p = 0.08), for miR-20a and miR-92a expression, respectively, was identified. Only miR-92a expression (-15.7%, 95%CI: -27.3 to-2.4, p = 0.02) was associated with PM2.5 exposure during the last month of pregnancy. C-MYC expression was downregulated in cord blood in association with prenatal PM2.5 exposure during the first trimester and the entire pregnancy, in the adjusted model. Discussion: Lower expression levels of the miR-17/92 cluster in cord blood in association with increased prenatal PM2.5 exposure were observed. Whether this oncogenic microRNA cluster plays a role in trans-placental carcinogenesis remains to be elucidated. | Notes: | Vrijens, K (corresponding author), Ctr Environm Sci Mol & Environm Epidemiol, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. karen.vrijens@uhasselt.be |
Other: | Vrijens, K (corresponding author), Ctr Environm Sci Mol & Environm Epidemiol, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. karen.vrijens@uhasselt.be | Keywords: | Particulate matter;miR-17/92;Birth cohort;Cord blood | Document URI: | http://hdl.handle.net/1942/33505 | ISSN: | 0160-4120 | e-ISSN: | 1873-6750 | DOI: | 10.1016/j.envint.2020.105860 | ISI #: | WOS:000603599200009 | Rights: | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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