Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33588
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dc.contributor.authorVandenabeele, Marjan-
dc.contributor.authorVeys, Lien-
dc.contributor.authorLemmens, Sophie-
dc.contributor.authorHadoux, Xavier-
dc.contributor.authorGelders, Geraldine-
dc.contributor.authorMasin, Luca-
dc.contributor.authorSerneels, Lutgarde-
dc.contributor.authorTHEUNIS, Jan-
dc.contributor.authorSaito, Takashi-
dc.contributor.authorSaido, Takaomi C.-
dc.contributor.authorJayapala, Murali-
dc.contributor.authorDE BOEVER, Patrick-
dc.contributor.authorDe Strooper, Bart-
dc.contributor.authorStalmans, Ingeborg-
dc.contributor.authorvan Wijngaarden, Peter-
dc.contributor.authorMoons, Lieve-
dc.contributor.authorDe Groef, Lies-
dc.date.accessioned2021-02-26T14:49:41Z-
dc.date.available2021-02-26T14:49:41Z-
dc.date.issued2021-
dc.date.submitted2021-02-23T13:10:17Z-
dc.identifier.citationActa Neuropathologica Communications, 9 (1) (Art N° 6)-
dc.identifier.issn2051-5960-
dc.identifier.urihttp://hdl.handle.net/1942/33588-
dc.description.abstractIn this study, we report the results of a comprehensive phenotyping of the retina of the App(NL-G-F) mouse. We demonstrate that soluble A beta accumulation is present in the retina of these mice early in life and progresses to A beta plaque formation by midlife. This rising A beta burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the App(NL-G-F) mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal A beta, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the App(NL-G-F) retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.-
dc.description.sponsorshipMV, LV, LuM and LDG are fellows of the Research Foundation Flanders (FWO). This research was supported by the Alzheimer's Research Foundation (SAO-FRA), the European Union Horizon 2020 Research and Innovation Program (2014-2020) (HERALD project, granted by the ATTRAC T consortium). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. XH and PvW acknowledge funding support from the H & L Hecht Trust and the Yulgilbar Alzheimer's Research Program.-
dc.language.isoen-
dc.publisherBMC-
dc.rightsThe Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or ther third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.-
dc.subject.otherAlzheimer's disease-
dc.subject.otherMouse model-
dc.subject.otherRetina-
dc.subject.otherRetinal imaging-
dc.subject.otherElectroretinogram-
dc.subject.otherHyperspectral imaging-
dc.titleThe AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume9-
local.format.pages16-
local.bibliographicCitation.jcatA1-
dc.description.notesDe Groef, L (corresponding author), Univ Leuven KU Leuven, Dept Biol, Neural Circuit Dev & Regenerat Res Grp, Naamsestr 61,Box 2464, B-3000 Leuven, Belgium.-
dc.description.notesLies.Degroef@kuleuven.be-
dc.description.otherDe Groef, L (corresponding author), Univ Leuven KU Leuven, Dept Biol, Neural Circuit Dev & Regenerat Res Grp, Naamsestr 61,Box 2464, B-3000 Leuven, Belgium. Lies.Degroef@kuleuven.be-
local.publisher.placeCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr6-
dc.identifier.doi10.1186/s40478-020-01102-5-
dc.identifier.pmid33407903-
dc.identifier.isiWOS:000610162800005-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Vandenabeele, Marjan; Veys, Lien; Gelders, Geraldine; Masin, Luca; Moons, Lieve; De Groef, Lies] Univ Leuven KU Leuven, Dept Biol, Neural Circuit Dev & Regenerat Res Grp, Naamsestr 61,Box 2464, B-3000 Leuven, Belgium.-
local.description.affiliation[Vandenabeele, Marjan; Veys, Lien; Gelders, Geraldine; Masin, Luca; Serneels, Lutgarde; De Strooper, Bart; Moons, Lieve; De Groef, Lies] Leuven Brain Inst, Leuven, Belgium.-
local.description.affiliation[Lemmens, Sophie; Stalmans, Ingeborg] Univ Hosp Leuven, Dept Ophthalmol, Leuven, Belgium.-
local.description.affiliation[Lemmens, Sophie; Stalmans, Ingeborg] Katholieke Univ Leuven, Res Grp Ophthalmol, Dept Neurosci, Leuven, Belgium.-
local.description.affiliation[Hadoux, Xavier; van Wijngaarden, Peter] Royal Victorian Eye & Ear Hosp, Ctr Eye Res Australia, East Melbourne, Australia.-
local.description.affiliation[Hadoux, Xavier; van Wijngaarden, Peter] Univ Melbourne, Dept Surg, Ophthalmol, Parkville, Vic, Australia.-
local.description.affiliation[Serneels, Lutgarde; De Boever, Patrick; De Strooper, Bart] Flemish Inst Biotechnol VIB, Ctr Brain & Dis Res, Leuven, Belgium.-
local.description.affiliation[Serneels, Lutgarde; De Boever, Patrick; De Strooper, Bart] Katholieke Univ Leuven, Lab Res Neurodegenerat Dis, Dept Neurosci, Leuven, Belgium.-
local.description.affiliation[Theunis, Jan] Flemish Inst Technol Res VITO, Hlth Unit, Mol, Belgium.-
local.description.affiliation[Saito, Takashi; Saido, Takaomi C.] RIKEN Ctr Brain Sci, Lab Proteolyt Neurosci, Saitama, Japan.-
local.description.affiliation[Saito, Takashi] Nagoya City Univ, Inst Brain Sci, Dept Neurocognit Sci, Grad Sch Med Sci, Nagoya, Aichi, Japan.-
local.description.affiliation[Saito, Takashi; Jayapala, Murali] Interuniv Microelect Ctr Imec, Leuven, Belgium.-
local.description.affiliation[De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.-
local.description.affiliation[De Boever, Patrick] Univ Antwerp, Dept Biol, Antwerp, Belgium.-
local.uhasselt.internationalyes-
item.fullcitationVandenabeele, Marjan; Veys, Lien; Lemmens, Sophie; Hadoux, Xavier; Gelders, Geraldine; Masin, Luca; Serneels, Lutgarde; THEUNIS, Jan; Saito, Takashi; Saido, Takaomi C.; Jayapala, Murali; DE BOEVER, Patrick; De Strooper, Bart; Stalmans, Ingeborg; van Wijngaarden, Peter; Moons, Lieve & De Groef, Lies (2021) The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research. In: Acta Neuropathologica Communications, 9 (1) (Art N° 6).-
item.contributorVandenabeele, Marjan-
item.contributorVeys, Lien-
item.contributorLemmens, Sophie-
item.contributorHadoux, Xavier-
item.contributorGelders, Geraldine-
item.contributorMasin, Luca-
item.contributorSerneels, Lutgarde-
item.contributorTHEUNIS, Jan-
item.contributorSaito, Takashi-
item.contributorSaido, Takaomi C.-
item.contributorJayapala, Murali-
item.contributorDE BOEVER, Patrick-
item.contributorDe Strooper, Bart-
item.contributorStalmans, Ingeborg-
item.contributorvan Wijngaarden, Peter-
item.contributorMoons, Lieve-
item.contributorDe Groef, Lies-
item.validationecoom 2022-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
crisitem.journal.issn2051-5960-
crisitem.journal.eissn2051-5960-
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