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http://hdl.handle.net/1942/33628
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DC Field | Value | Language |
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dc.contributor.author | VERSTRAELEN, Stefanie | - |
dc.contributor.author | Nitsche, Michael | - |
dc.contributor.author | VAN DUN, Kim | - |
dc.contributor.author | DEPESTELE, Siel | - |
dc.contributor.author | VAN HOORNWEDER, Sybren | - |
dc.contributor.author | JAMIL, Asif | - |
dc.contributor.author | GHASEMIAN SHIRVAN, Ensiyeh | - |
dc.contributor.author | Swinnen, Stephan | - |
dc.contributor.author | VAN MALDEREN, Shanti | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | MEESEN, Raf | - |
dc.date.accessioned | 2021-03-03T12:17:35Z | - |
dc.date.available | 2021-03-03T12:17:35Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-03-03T09:18:30Z | - |
dc.identifier.citation | Brain Stimulation, 14 (2) , p. 423 -434 | - |
dc.identifier.issn | 1935-861X | - |
dc.identifier.uri | http://hdl.handle.net/1942/33628 | - |
dc.description.abstract | Background: The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking. Objective: We investigated how left (PMd L) and right PMd (PMd R) are causally involved in planning and executing bimanual movements, using short-train repetitive transcranial magnetic stimulation (rTMS). Additionally, we explored to what extent the observed rTMS-induced modulation of performance could be explained by rTMS-induced modulation of PMd-M1 interhemispheric interactions (IHI). Methods: Twenty healthy adults (mean age ± SD = 22.85 ± 3.73 years) participated in two sessions, in which either PMd L or PMd R was targeted with rTMS (10 Hz) in a pseudo-randomized design. PMd functionality was transiently modulated during the planning or execution of a complex bimanual task, whereby the participant was asked to track a moving dot by controlling two dials. The effect of rTMS on several performance measures was investigated. Concurrently, rTMS-induced modulation of PMd-M1 IHI was measured using a dual-coil paradigm, and associated with the rTMS-induced performance modulation. Results: rTMS over PMd L during planning increased bilateral hand movement speed (p = 0.03), thereby improving movement accuracy (p = 0.02). In contrast, rTMS over PMd R during both planning and execution induced deterioration of movement stability (p = 0.04). rTMS-induced modulation of PMd-M1 IHI during planning did not predict rTMS-induced performance modulation. Conclusion: The current findings support the growing evidence on PMd L dominance during motor planning, as PMd L was crucially involved in planning the speed of each hand, subserving bimanual coordination accuracy. Moreover, the current results suggest that PMd R fulfills a role in continuous adjustment processes of movement. | - |
dc.description.sponsorship | This work was supported by the Research Fund KU Leuven (C16/ 15/070), Research Foundation Flanders (I005018N, G089818N and G039821N), Excellence of Science (EOS 30446199, MEMODYN), the Hercules fund AUHL/11/01 (R-3987), and the Special Research Fund (BOF) of Hasselt University (BOF20KP18, BOF17BL03, BOF20DCOV05). MAN is in the Scientific Advisory Boards of Neuroelectrics, and NeuroDevice. The other authors declare no competing financial interests. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Authors are thankful to R. Clerckx for his support in programming the bimanual task and for his help in preprocessing the acquired performance data. We additionally thank several master students of KU Leuven and UHasselt, who assisted with data collection; and dr. Anna Ivanova for her assistance in performing statistical analyses. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject.other | Bimanual coordination | - |
dc.subject.other | Dorsal premotor cortex | - |
dc.subject.other | Repetitive transcranial magnetic stimulation | - |
dc.subject.other | Interhemispheric interaction | - |
dc.subject.other | Virtual lesion | - |
dc.title | Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements e A neuro-navigated rTMS study | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.authors | George | - |
dc.identifier.epage | 434 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 423 | - |
dc.identifier.volume | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.brs.2021.02.006 | - |
dc.identifier.pmid | 33621675 | - |
dc.identifier.isi | WOS:000632697000033 | - |
dc.identifier.eissn | 1876-4754 | - |
local.provider.type | - | |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | VERSTRAELEN, Stefanie; Nitsche, Michael; VAN DUN, Kim; DEPESTELE, Siel; VAN HOORNWEDER, Sybren; JAMIL, Asif; GHASEMIAN SHIRVAN, Ensiyeh; Swinnen, Stephan; VAN MALDEREN, Shanti; CUYPERS, Koen & MEESEN, Raf (2021) Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements e A neuro-navigated rTMS study. In: Brain Stimulation, 14 (2) , p. 423 -434. | - |
item.contributor | VERSTRAELEN, Stefanie | - |
item.contributor | Nitsche, Michael | - |
item.contributor | VAN DUN, Kim | - |
item.contributor | DEPESTELE, Siel | - |
item.contributor | VAN HOORNWEDER, Sybren | - |
item.contributor | JAMIL, Asif | - |
item.contributor | GHASEMIAN SHIRVAN, Ensiyeh | - |
item.contributor | Swinnen, Stephan | - |
item.contributor | VAN MALDEREN, Shanti | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | MEESEN, Raf | - |
crisitem.journal.issn | 1935-861X | - |
crisitem.journal.eissn | 1876-4754 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Verstraelen et al. 2021.pdf | Published version | 1.66 MB | Adobe PDF | View/Open |
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