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http://hdl.handle.net/1942/3363
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DC Field | Value | Language |
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dc.contributor.author | GOETGHEBEUR, Els | - |
dc.contributor.author | Shapiro, SH | - |
dc.date.accessioned | 2007-11-28T08:03:40Z | - |
dc.date.available | 2007-11-28T08:03:40Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | STATISTICS IN MEDICINE, 15(24). p. 2813-2826 | - |
dc.identifier.issn | 0277-6715 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3363 | - |
dc.description.abstract | Assuming that a drug is active and different from placebo, a patient's gain or loss is likely to depend on how much of the drug is taken and when. The present paper motivates the ethical imperative of statistical compliance analysis by considering important clinical questions, the advent of more precise compliance measuring instruments and new statistical efforts towards well understood analyses that seek to preserve scientific integrity. An extension of Efron and Feldman's approach is developed which exploits the randomization assumption in combination with structural models. It also generates more promising designs and alternative statistical approaches. | - |
dc.description.sponsorship | We thank H. Callaert, A. Heyting, S. Pocock, J. Urquhart and the statisticians from the Janssen Research Foundation for helpful discussions on the topic. This research has been sponsored by the I WT, ‘Vlaams Instituut ter bevordering van het wetenschappelijk-technologisch onderzoek in de industrie’. | - |
dc.language.iso | en | - |
dc.publisher | JOHN WILEY & SONS LTD | - |
dc.rights | 1996 by John Wiley & Sons, Ltd. | - |
dc.title | Analysing non-compliance in clinical trials: Ethical imperative or mission impossible? | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2826 | - |
dc.identifier.issue | 24 | - |
dc.identifier.spage | 2813 | - |
dc.identifier.volume | 15 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | RIJKS UNIV LIMBUG,NL-6200 MD MAASTRICHT,NETHERLANDS. MCGILL UNIV,MONTREAL,PQ H3A 1A2,CANADA.Goetghebeur, EJT, LIMBURGS UNIV CTR,B-3590 DIEPENBEEK,BELGIUM. | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1002/(SICI)1097-0258(19961230)15:24<2813::AID-SIM366>3.0.CO;2-U | - |
dc.identifier.isi | A1996VY09500013 | - |
dc.identifier.eissn | 1097-0258 | - |
dc.identifier.eissn | 1097-0258 | - |
local.provider.type | - | |
local.uhasselt.international | yes | - |
item.fullcitation | GOETGHEBEUR, Els & Shapiro, SH (1996) Analysing non-compliance in clinical trials: Ethical imperative or mission impossible?. In: STATISTICS IN MEDICINE, 15(24). p. 2813-2826. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | GOETGHEBEUR, Els | - |
item.contributor | Shapiro, SH | - |
crisitem.journal.issn | 0277-6715 | - |
crisitem.journal.eissn | 1097-0258 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Statistics in Medicine - 30 December 1996 - GOETGHEBEUR - ANALYSING NON‐COMPLIANCE IN CLINICAL TRIALS ETHICAL IMPERATIVE.pdf Restricted Access | Published version | 960.31 kB | Adobe PDF | View/Open Request a copy |
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