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http://hdl.handle.net/1942/33718
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DC Field | Value | Language |
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dc.contributor.author | Bastiaensen, Michiel | - |
dc.contributor.author | Gys, Celine | - |
dc.contributor.author | Colles, Ann | - |
dc.contributor.author | Verheyen, Veerle | - |
dc.contributor.author | Koppen, Gudrun | - |
dc.contributor.author | Govarts, Eva | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Morrens, Bert | - |
dc.contributor.author | Loots, Ilse | - |
dc.contributor.author | De Decker, Annelies | - |
dc.contributor.author | Nelen, Vera | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | De Henauw, Stefaan | - |
dc.contributor.author | Van Larebeke, Nik | - |
dc.contributor.author | Schoeters, Greet | - |
dc.contributor.author | Covaci, Adrian | - |
dc.date.accessioned | 2021-03-19T14:56:47Z | - |
dc.date.available | 2021-03-19T14:56:47Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-03-16T12:59:19Z | - |
dc.identifier.citation | ENVIRONMENT INTERNATIONAL, 147 (Art N° 106368) | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33718 | - |
dc.description.abstract | The ubiquitous use of organophosphate flame retardants and plasticizers (PFRs) in a variety of consumer products has led to widespread human exposure. Since certain PFRs are developmental and carcinogenic toxicants, detailed exposure assessments are essential to investigate the risk associated with environmental exposure levels. However, such data are still lacking for European countries. In this study, concentrations of thirteen PFR metabolites were measured in urine samples from 600 adolescents from Flanders, Belgium. 1-Hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP), diphenyl phosphate (DPHP), bis(1,3-dichloro-isopropyl) phosphate (BDCIPP), 2-hydroxyethyl bis(2-butoxyethyl) phosphate (BBOEHEP), 2-ethylhexyl phenyl phosphate (EHPHP) and 2-ethyl-5-hydroxyhexyl diphenyl phosphate (5-HO-EHDPHP) were frequently detected (>83%) in all participants. Comparisons with study populations from outside the EU showed that urinary levels of DPHP, BDCIPP and BCIPHIPP were generally within the same range. Only exposure to 2-ethylhexyl diphenyl phosphate (EHDPHP) was presumably higher in Flemish adolescents. However, determinants analysis through multivariate regression analyses did not reveal significant predictors that may explain this finding. Significantly higher levels of BDCIPP were observed in participants with new decorations at home, while adolescents with highly educated parents had higher levels of BBOEHEP and BDCIPP. Furthermore, multiple PFR metabolite concentrations followed a seasonal pattern. Estimated daily intakes (EDIs) were calculated from the internal dose by including fractions of urinary excretion (FUE) estimated in in vitro metabolism studies. EDIs ranged from 6.3 ng/kg bw/day for TBOEP to 567.7 ng/kg bw/day for EHDPHP, which were well below the available oral reference doses for all investigated PFRs. This suggests that the associated risk is low at present. This is the first report on internal exposure to seven commonly used PFRs in a European population. | - |
dc.description.sponsorship | We thank the participating adolescents and their families. Without their effort this study would not have been possible. We also thank J. Bombeke for his assistance during the sample preparation. This paper is based on research conducted within the framework of the Flemish Center of Expertise on Environment and Health (FLEHS 2016-2020), funded by the Government of Flanders, Department of Environment & Spatial Development. The views expressed herein are those of the author (s) and are not necessarily endorsed by the government of Flanders. The Flemish Environment and Health Study was commissioned, financed and steered by the Ministry of the Flemish Community (Department of Environment) (grant ID: Steunpunt Milieu & Gezondheid), including the partial funding of the Ph.D. of Michiel Bastiaensen. Celine Gys acknowledges the funding of a PhD fellowship from Research Foundation Flanders (project G0E5216N). | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.rights | 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license | - |
dc.subject.other | Organophosphate flame retardants | - |
dc.subject.other | Exposure assessment | - |
dc.subject.other | Human biomonitoring | - |
dc.subject.other | FLEHS IV | - |
dc.subject.other | Belgium | - |
dc.subject.other | Adolescents | - |
dc.title | Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14–15 years) from the Flemish Environment and Health Study | - |
dc.type | Journal Contribution | - |
dc.identifier.spage | 106368 | - |
dc.identifier.volume | 147 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Covaci, A (corresponding author), Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
dc.description.notes | adrian.covaci@uantwerpen.be | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 106368 | - |
dc.identifier.doi | 10.1016/j.envint.2020.106368 | - |
dc.identifier.pmid | 33421765 | - |
dc.identifier.isi | WOS:000613514200002 | - |
dc.contributor.orcid | Bastiaensen, Michiel/0000-0001-7710-800X; Colles, | - |
dc.contributor.orcid | Ann/0000-0002-6629-7973; Verheyen, Veerle/0000-0002-5262-5665; Govarts, | - |
dc.contributor.orcid | Eva/0000-0002-6075-4862 | - |
dc.identifier.eissn | 1873-6750 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Bastiaensen, Michiel; Gys, Celine; Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Colles, Ann; Verheyen, Veerle; Koppen, Gudrun; Govarts, Eva; Schoeters, Greet] VITO Hlth, Boeretang 200, B-2400 Mol, Belgium. | - |
local.description.affiliation | [Verheyen, Veerle; Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Bruckers, Liesbeth] Hasselt Univ, Data Sci Inst, BioStat, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Morrens, Bert; Loots, Ilse] Univ Antwerp, Fac Social Sci, Sint Jacobstr 2, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [De Decker, Annelies; Nelen, Vera] Prov Inst Hyg, Kronenburgstr 45, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, Agoralaan, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [De Henauw, Stefaan] Univ Ghent, Dept Publ Hlth, C Heymanslaan 10, B-9000 Ghent, Belgium. | - |
local.description.affiliation | [Van Larebeke, Nik] Vrije Univ Brussel, Analyt Environm & Geochem, Pleinlaan 2, B-1050 Brussels, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.contributor | Bastiaensen, Michiel | - |
item.contributor | Gys, Celine | - |
item.contributor | Colles, Ann | - |
item.contributor | Verheyen, Veerle | - |
item.contributor | Koppen, Gudrun | - |
item.contributor | Govarts, Eva | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Morrens, Bert | - |
item.contributor | Loots, Ilse | - |
item.contributor | De Decker, Annelies | - |
item.contributor | Nelen, Vera | - |
item.contributor | NAWROT, Tim | - |
item.contributor | De Henauw, Stefaan | - |
item.contributor | Van Larebeke, Nik | - |
item.contributor | Schoeters, Greet | - |
item.contributor | Covaci, Adrian | - |
item.accessRights | Open Access | - |
item.fullcitation | Bastiaensen, Michiel; Gys, Celine; Colles, Ann; Verheyen, Veerle; Koppen, Gudrun; Govarts, Eva; BRUCKERS, Liesbeth; Morrens, Bert; Loots, Ilse; De Decker, Annelies; Nelen, Vera; NAWROT, Tim; De Henauw, Stefaan; Van Larebeke, Nik; Schoeters, Greet & Covaci, Adrian (2021) Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14–15 years) from the Flemish Environment and Health Study. In: ENVIRONMENT INTERNATIONAL, 147 (Art N° 106368). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0160-4120 | - |
crisitem.journal.eissn | 1873-6750 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0160412020323229-main.pdf | Published version | 618.19 kB | Adobe PDF | View/Open |
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