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Title: | Photobiomodulation therapy for the prevention of acute radiation dermatitis in head and neck cancer patients (DERMISHEAD trial) | Authors: | ROBIJNS, Jolien LODEWIJCKX, Joy Claes, Stefan Van Bever, Leen Pannekoeke, Luc Censabella, Sandrine Bussé, Lore Colson, Dora Kaminski, Iris Broux, Victoria Puts, Sofie Vanmechelen, Sofie Timmermans, An Noé, Leen BULENS, Paul Govers, Mieke MAES, Annelies MEBIS, Jeroen |
Issue Date: | 2021 | Publisher: | Source: | RADIOTHERAPY AND ONCOLOGY, 158 , p. 268 -275 | Abstract: | Background and purpose The purpose of this study was to investigate the effectiveness of photobiomodulation therapy (PBMT) for the prevention of acute radiation dermatitis (ARD) in head and neck cancer (HNC) patients. Materials and methods A randomised, placebo-controlled trial (RCT) with 46 HNC patients who underwent radiotherapy (RT) with or without concomitant chemotherapy was set up (DERMISHEAD trial). Patients were randomised to receive PBM or placebo treatments from the first day of RT (2×/week) alongside the institutional skincare. The severity of skin reactions was assessed by the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4.03 (NCI-CTCAE v4.03) and the Radiotherapy-Induced Skin Reaction Assessment Scale (RISRAS). Quality of life (QoL) was evaluated using the Skindex-16 questionnaire. Results PBMT significantly reduced NCI-CTCAE grade 2–3 ARD with 49% at the end of RT. Conclusion The results of the first RCT in HNC patients showed that PBMT is an effective method to prevent the development of severe ARD. These results support the implementation of PBM in the clinical oncology – radiotherapy practice. | Keywords: | Radiodermatitis;Photobiomodulation;Head and neck cancer;Supportive cancer care | Document URI: | http://hdl.handle.net/1942/33784 | ISSN: | 0167-8140 | e-ISSN: | 1879-0887 | DOI: | 10.1016/j.radonc.2021.03.002 | ISI #: | 000648874300038 | Rights: | 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).⇑Corresponding author at: Hasselt University, Faculty of Medicine and Lifesciences, LCRC, Martelarenlaan 42, 3500 Hasselt, Belgium.E-mail addresses:jolien.robijns@uhasselt.be(J. Robijns),Jeroen.mebis@jessazh.be(J. Mebis).Radiotherapy and Oncology 158 (2021) 268–275Contents lists available atScienceDirectRadiotherapy and Oncologyjournal homepage: www.thegreenjournal.com | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Robijns_DERMISHEAD_2021.pdf | Published version | 554.02 kB | Adobe PDF | View/Open |
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