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http://hdl.handle.net/1942/33821
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DC Field | Value | Language |
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dc.contributor.author | van Heerden, Jaques | - |
dc.contributor.author | Kruger, Mariana | - |
dc.contributor.author | Esterhuizen, Tonya Marianne | - |
dc.contributor.author | PINXTEN, Wim | - |
dc.date.accessioned | 2021-04-02T12:43:07Z | - |
dc.date.available | 2021-04-02T12:43:07Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-03-02T11:01:42Z | - |
dc.identifier.citation | PEDIATRIC BLOOD & CANCER, 68 (7), (Art N° e28923) | - |
dc.identifier.issn | 1545-5009 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33821 | - |
dc.description.abstract | Background Neuroblastoma (NB) contributes the most to the mortality of childhood malignancies worldwide. The disease spectrum is heterogenous and the management complex and costly, especially in advanced disease or disease with adverse biology. In low- and middle-income countries (LMICs) the majority of NB presents in advanced stages. Therefore, with limited resources and poor prognosis the treatment of NB is often not a priority. The aim of the study was to evaluate the research activities and perceptions of the management of NB that determine the research and treatment approaches in LMICs. Methods Data were sourced from identifying NB trials open to LMIC. s on NB research presented at the International Society for Paediatric Oncology (SIOP) Congresses between 2014 and 2020 were evaluated according to income status. An online survey evaluating medical views on NB in LMICs and the effect on the management was conducted. Descriptive analysis was done. Where appropriate categorical association between covariates was assessed using the Pearson chi-square (chi(2)) test or Fishers exact test. Results There were 15/562 (2.7%) trials open to LMIC. Only six of 138 (4.3%) LMIC participated in NB trials. Of the 688 abstracts presented between 2014 and 2020 at the SIOP International Congress on NB as primary subject, 297 (42.7%) were from LMICs. Only two were from low-income countries (LICs). Sixty-one countries responded to the NB survey. Positive views towards NB management were present when treatment was based on a national protocol, the availability of trimodal or advanced treatment options were present, and when a balance of metastatic or local disease were treated. Conclusion Management of NB in LMICs should include increased advocacy and research as well as implementation of national management strategies. | - |
dc.description.sponsorship | We appreciate the support offered by Profs Kate Matthey, Guillermo Chantada and Scott Howard on behalf of the Global Neuroblastoma Network, Profs Laila Heississen and Lorna Renner on behalf of SIOPAfrica, Dr Joyce Balagadde-Kambugu on behalf of POGEA in the distribution of the survey. Our gratitude extends to all the participants of the survey. Dr van Heerden, as staff member of the Department of Paediatric Haematology and Oncology, Antwerp University Hospital, University of Antwerp acknowledges theDepartment for Research Support as well as the vzw Kinderkankerfonds, Belgium for the initial research grants. We acknowledge the Spanish and French translation services done by Mr Jorge Luis Rentaria, Mr Steve Populaire and Mrs Gaelle DuFour. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2021 Wiley Periodicals LLC | - |
dc.subject.other | low‐ | - |
dc.subject.other | and middle‐ | - |
dc.subject.other | income countries | - |
dc.subject.other | management | - |
dc.subject.other | neuroblastoma | - |
dc.title | Neuroblastoma: The basis for cure in limited-resource settings | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 7 | - |
dc.identifier.volume | 68 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | van Heerden, J (corresponding author), Stellenbosch Univ, Tygerberg Hosp, Dept Paediat & Child Hlth, Paediat Haematol & Oncol,Fac Med & Hlth Sci, Cape Town, South Africa. | - |
dc.description.notes | Jaques.vanheerden@uza.be | - |
dc.description.other | van Heerden, J (corresponding author), Stellenbosch Univ, Tygerberg Hosp, Dept Paediat & Child Hlth, Paediat Haematol & Oncol,Fac Med & Hlth Sci, Cape Town, South Africa. Jaques.vanheerden@uza.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e28923 | - |
dc.identifier.doi | 10.1002/pbc.28923 | - |
dc.identifier.pmid | 33533177 | - |
dc.identifier.isi | WOS:000613949900001 | - |
dc.contributor.orcid | Kruger, Mariana/0000-0002-6838-0180 | - |
dc.identifier.eissn | 1545-5017 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [van Heerden, Jaques; Kruger, Mariana] Stellenbosch Univ, Tygerberg Hosp, Dept Paediat & Child Hlth, Paediat Haematol & Oncol,Fac Med & Hlth Sci, Cape Town, South Africa. | - |
local.description.affiliation | [van Heerden, Jaques] Antwerp Univ Hosp, Dept Paediat, Paediat Haematol & Oncol, Antwerp, Belgium. | - |
local.description.affiliation | [Esterhuizen, Tonya Marianne] Stellenbosch Univ, Div Epidemiol & Biostat, Fac Med & Hlth Sci, Cape Town, South Africa. | - |
local.description.affiliation | [Pinxten, Wim] Hasselt Univ, Dept Healthcare & Eth, Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.contributor | van Heerden, Jaques | - |
item.contributor | Kruger, Mariana | - |
item.contributor | Esterhuizen, Tonya Marianne | - |
item.contributor | PINXTEN, Wim | - |
item.accessRights | Restricted Access | - |
item.fullcitation | van Heerden, Jaques; Kruger, Mariana; Esterhuizen, Tonya Marianne & PINXTEN, Wim (2021) Neuroblastoma: The basis for cure in limited-resource settings. In: PEDIATRIC BLOOD & CANCER, 68 (7), (Art N° e28923). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1545-5009 | - |
crisitem.journal.eissn | 1545-5017 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Pediatric Blood Cancer - 2021 - Heerden - Neuroblastoma The basis for cure in limited‐resource settings.pdf Restricted Access | Published version | 1.13 MB | Adobe PDF | View/Open Request a copy |
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