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http://hdl.handle.net/1942/33833
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DC Field | Value | Language |
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dc.contributor.author | BROUX, Bieke | - |
dc.contributor.author | Zandee, Stephanie | - |
dc.contributor.author | Gowing, Elizabeth | - |
dc.contributor.author | Charabati, Marc | - |
dc.contributor.author | Lecuyer, Marc-Andre | - |
dc.contributor.author | Tastet, Olivier | - |
dc.contributor.author | Hachehouche, Lamia | - |
dc.contributor.author | Bourbonniere, Lyne | - |
dc.contributor.author | Ouimet, Jean-Philippe | - |
dc.contributor.author | Lemaitre, Florent | - |
dc.contributor.author | Larouche, Sandra | - |
dc.contributor.author | Cayrol, Romain | - |
dc.contributor.author | Bouthillier, Alain | - |
dc.contributor.author | Moumdjian, Robert | - |
dc.contributor.author | Lahav, Boaz | - |
dc.contributor.author | Poirier, Josee | - |
dc.contributor.author | Duquette, Pierre | - |
dc.contributor.author | Arbour, Nathalie | - |
dc.contributor.author | PEELEN, Evelyn | - |
dc.contributor.author | Prat, Alexandre | - |
dc.date.accessioned | 2021-04-02T13:34:09Z | - |
dc.date.available | 2021-04-02T13:34:09Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-03-09T12:37:27Z | - |
dc.identifier.citation | Neurology-Neuroimmunology & Neuroinflammation, 7 (6) (Art N° e870) | - |
dc.identifier.uri | http://hdl.handle.net/1942/33833 | - |
dc.description.abstract | Objective To investigate the involvement of interleukin (IL)-26 in neuroinflammatory processes in multiple sclerosis (MS), in particular in blood-brain barrier (BBB) integrity. Methods Expression of IL-26 was measured in serum, CSF, in vitro differentiated T helper (T-H) cell subsets, and postmortem brain tissue of patients with MS and controls by ELISA, quantitative PCR, and immunohistochemistry. Primary human and mouse BBB endothelial cells (ECs) were treated with IL-26 in vitro and assessed for BBB integrity. RNA sequencing was performed on IL-26-treated human BBB ECs. Myelin oligodendrocyte glycoprotein(35-55) experimental autoimmune encephalomyelitis (EAE) mice were injected IP with IL-26. BBB leakage and immune cell infiltration were assessed in the CNS of these mice using immunohistochemistry and flow cytometry. Results IL-26 expression was induced in T-H lymphocytes by T(H)17-inducing cytokines and was upregulated in the blood and CSF of patients with MS. CD4(+)IL-26(+) T lymphocytes were found in perivascular infiltrates in MS brain lesions, and both receptor chains for IL-26 (IL-10R2 and IL-20R1) were detected on BBB ECs in vitro and in situ. In contrast to IL-17 and IL-22, IL-26 promoted integrity and reduced permeability of BBB ECs in vitro and in vivo. In EAE, IL-26 reduced disease severity and proinflammatory lymphocyte infiltration into the CNS, while increasing infiltration of Tregs. Conclusions Our study demonstrates that although IL-26 is preferentially expressed by T(H)17 lymphocytes, it promotes BBB integrity in vitro and in vivo and is protective in chronic EAE, highlighting the functional diversity of cytokines produced by T(H)17 lymphocytes. | - |
dc.description.sponsorship | This work was funded by a grant from the Canadian Institutes of Health Research (MOP136980). A. Prat holds a senior Canada Research Chair in Multiple Sclerosis. M. Charabati held a postdoctoral studentship from the Fonds de recherche du Quebec-Sante (FRQS) and is now supported by a doctoral scholarship from the Multiple Sclerosis Society of Canada (MSSC). E. Peelen and S. Zandee held a postdoctoral studentship from the FRQS/MSSC Partnership Award. B. Broux held a postdoctoral studentship from Fonds Wetenschappelijk Onderzoek-Vlaanderen. L. Hachehouche held PhD studentships from the MSSC, FRQS, and Neuroinflammation Training Program. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. | - |
dc.title | Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 6 | - |
dc.identifier.volume | 7 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Prat, A (corresponding author), Univ Montreal, Fac Med, Multiple Sclerosis Clin, Res Ctr,Ctr Hosp Univ Montreal CRCHUM,Dept Neuros, Montreal, PQ, Canada. | - |
dc.description.notes | a.prat@umontreal.ca | - |
dc.description.other | Prat, A (corresponding author), Univ Montreal, Fac Med, Multiple Sclerosis Clin, Res Ctr,Ctr Hosp Univ Montreal CRCHUM,Dept Neuros, Montreal, PQ, Canada. a.prat@umontreal.ca | - |
local.publisher.place | TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e870 | - |
dc.identifier.doi | 10.1212/NXI.0000000000000870 | - |
dc.identifier.isi | WOS:000618947900004 | - |
dc.contributor.orcid | Broux, Bieke/0000-0001-8509-2415; Lecuyer, | - |
dc.contributor.orcid | Marc-Andre/0000-0003-0465-6122; Arbour, Nathalie/0000-0002-3718-1584; | - |
dc.contributor.orcid | Zandee, Stephanie/0000-0003-0812-676X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Broux, Bieke; Zandee, Stephanie; Gowing, Elizabeth; Charabati, Marc; Lecuyer, Marc-Andre; Tastet, Olivier; Hachehouche, Lamia; Bourbonniere, Lyne; Ouimet, Jean-Philippe; Lemaitre, Florent; Larouche, Sandra; Cayrol, Romain; Lahav, Boaz; Poirier, Josee; Duquette, Pierre; Arbour, Nathalie; Peelen, Evelyn; Prat, Alexandre] Univ Montreal, Fac Med, Neuroimmunol Unit, Res Ctr,Ctr Hosp Univ Montreal CRCHUM,Dept Neuros, Montreal, PQ, Canada. | - |
local.description.affiliation | [Broux, Bieke; Zandee, Stephanie; Gowing, Elizabeth; Charabati, Marc; Lecuyer, Marc-Andre; Tastet, Olivier; Hachehouche, Lamia; Bourbonniere, Lyne; Ouimet, Jean-Philippe; Lemaitre, Florent; Larouche, Sandra; Cayrol, Romain; Lahav, Boaz; Poirier, Josee; Duquette, Pierre; Arbour, Nathalie; Peelen, Evelyn; Prat, Alexandre] Univ Montreal, Fac Med, Multiple Sclerosis Clin, Res Ctr,Ctr Hosp Univ Montreal CRCHUM,Dept Neuros, Montreal, PQ, Canada. | - |
local.description.affiliation | [Broux, Bieke] Hasselt Univ, Biomed Res Inst, Hasselt, Belgium. | - |
local.description.affiliation | [Broux, Bieke] Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [Bouthillier, Alain; Moumdjian, Robert] Univ Montreal, Ctr Hosp Univ Montreal CHUM, Fac Med, Div Neurosurg, Montreal, PQ, Canada. | - |
local.uhasselt.international | yes | - |
item.contributor | BROUX, Bieke | - |
item.contributor | Zandee, Stephanie | - |
item.contributor | Gowing, Elizabeth | - |
item.contributor | Charabati, Marc | - |
item.contributor | Lecuyer, Marc-Andre | - |
item.contributor | Tastet, Olivier | - |
item.contributor | Hachehouche, Lamia | - |
item.contributor | Bourbonniere, Lyne | - |
item.contributor | Ouimet, Jean-Philippe | - |
item.contributor | Lemaitre, Florent | - |
item.contributor | Larouche, Sandra | - |
item.contributor | Cayrol, Romain | - |
item.contributor | Bouthillier, Alain | - |
item.contributor | Moumdjian, Robert | - |
item.contributor | Lahav, Boaz | - |
item.contributor | Poirier, Josee | - |
item.contributor | Duquette, Pierre | - |
item.contributor | Arbour, Nathalie | - |
item.contributor | PEELEN, Evelyn | - |
item.contributor | Prat, Alexandre | - |
item.validation | ecoom 2022 | - |
item.fullcitation | BROUX, Bieke; Zandee, Stephanie; Gowing, Elizabeth; Charabati, Marc; Lecuyer, Marc-Andre; Tastet, Olivier; Hachehouche, Lamia; Bourbonniere, Lyne; Ouimet, Jean-Philippe; Lemaitre, Florent; Larouche, Sandra; Cayrol, Romain; Bouthillier, Alain; Moumdjian, Robert; Lahav, Boaz; Poirier, Josee; Duquette, Pierre; Arbour, Nathalie; PEELEN, Evelyn & Prat, Alexandre (2020) Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function. In: Neurology-Neuroimmunology & Neuroinflammation, 7 (6) (Art N° e870). | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2332-7812 | - |
crisitem.journal.eissn | 2332-7812 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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e870.full.pdf | Published version | 1.51 MB | Adobe PDF | View/Open |
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