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http://hdl.handle.net/1942/33893
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DC Field | Value | Language |
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dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | Tersalvi, Gregorio | - |
dc.contributor.author | Schouteden, Joren | - |
dc.contributor.author | DEFERM, Sebastien | - |
dc.contributor.author | GRUWEZ, Henri | - |
dc.contributor.author | DE MOOR, Bart | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2021-04-09T13:07:11Z | - |
dc.date.available | 2021-04-09T13:07:11Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-03-30T12:46:59Z | - |
dc.identifier.citation | EUROPEAN JOURNAL OF HEART FAILURE, 23(7), p. 1110-1119 | - |
dc.identifier.issn | 1388-9842 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33893 | - |
dc.description.abstract | Aims To study loop diuretic response and effect of loop diuretic omission in ambulatory heart failure (HF) patients on chronic low-dose loop diuretics. Methods and results Urine collections were performed on two consecutive days in 40 ambulatory HF patients with 40-80 mg furosemide (day 1 with loop diuretic; day 2 without loop diuretic). Three phases were collected each day: (i) first 6 h; (ii) rest of the day; and (iii) night. On the day of loop diuretic intake, the total natriuresis was 125.9 (86.9-155.0) mmol/24 h and urine output was 1650 (1380-2025) mL/24 h. There was a clear loop diuretic response with a natriuresis of 9.4 (6.7-15.9) mmol/h and a urine output of 117 (83-167) mL/h during the first 6 h, followed by a significant drop in natriuresis and urine output during the rest of the day [2.6 (1.8-4.8) mmol/h and 55 (33-71) mL/h] and night [2.2 (1.6-3.5) mmol/h and 44 (34-73) mL/h]. On day 2, after loop diuretic omission, the natriuresis and urine output remained similarly low the entire day, resulting in a 50% reduction in natriuresis [55.1 (33.5-77.7) mmol/24 h; P < 0.001] and a 31% reduction in urine output [1035 (875-1425) mL/24 h; P < 0.001] compared with the day of loop diuretic intake. Conclusion Patients with HF on chronic loop diuretic treatment still have a clear diuretic response phase, while loop diuretic omission leads to a significant drop in natriuresis and urine output, arguing against routine cessation of low-dose loop diuretics. | - |
dc.description.sponsorship | Jeroen Dauw, Sebastien Deferm, Henri Gruwez and Wilfried Mullens are researchers for the Limburg Clinical Research Center (LCRC) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2021European Society of Cardiology | - |
dc.subject.other | Loop diuretics | - |
dc.subject.other | Heart failure | - |
dc.subject.other | Diuretic response | - |
dc.subject.other | Natriuresis | - |
dc.subject.other | Urine output | - |
dc.title | Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low-dose loop diuretic therapy | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1119 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1110 | - |
dc.identifier.volume | 23 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | wilfried.mullens@zol.be | - |
dc.description.other | Mullens, W (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. wilfried.mullens@zol.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ejhf.2145 | - |
dc.identifier.pmid | 33641220 | - |
dc.identifier.isi | WOS:000628917700001 | - |
dc.identifier.eissn | 1879-0844 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Dauw, Jeroen; Martens, Pieter; Tersalvi, Gregorio; Schouteden, Joren; Deferm, Sebastien; Gruwez, Henri; Nijst, Petra; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Dauw, Jeroen; Deferm, Sebastien; Gruwez, Henri] UHasselt Hasselt Univ, Doctoral Sch Med & Life Sci, LCRC, Diepenbeek, Belgium. | - |
local.description.affiliation | [De Moor, Bart] Jessa Ziekenhuis, Dept Nephrol, Hasselt, Belgium. | - |
local.description.affiliation | [De Moor, Bart; Mullens, Wilfried] UHasselt Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, LCRC, Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | Tersalvi, Gregorio | - |
item.contributor | Schouteden, Joren | - |
item.contributor | DEFERM, Sebastien | - |
item.contributor | GRUWEZ, Henri | - |
item.contributor | DE MOOR, Bart | - |
item.contributor | NIJST, Petra | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
item.fullcitation | DAUW, Jeroen; MARTENS, Pieter; Tersalvi, Gregorio; Schouteden, Joren; DEFERM, Sebastien; GRUWEZ, Henri; DE MOOR, Bart; NIJST, Petra; DUPONT, Matthias & MULLENS, Wilfried (2021) Diuretic response and effects of diuretic omission in ambulatory heart failure patients on chronic low-dose loop diuretic therapy. In: EUROPEAN JOURNAL OF HEART FAILURE, 23(7), p. 1110-1119. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1388-9842 | - |
crisitem.journal.eissn | 1879-0844 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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European J of Heart Fail - 2021 - Dauw - Diuretic response and effects of diuretic omission in ambulatory heart failure.pdf | Published version | 1.29 MB | Adobe PDF | View/Open |
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