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http://hdl.handle.net/1942/33904
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DC Field | Value | Language |
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dc.contributor.author | Mendez, Daniel | - |
dc.contributor.author | Escalona-Arranz, Julio C. | - |
dc.contributor.author | Foubert, Kenn | - |
dc.contributor.author | Matheeussen, An | - |
dc.contributor.author | Van der Auwera, Anastasia | - |
dc.contributor.author | Piazza, Stefano | - |
dc.contributor.author | CUYPERS, Ann | - |
dc.contributor.author | Cos, Paul | - |
dc.contributor.author | Pieters, Luc | - |
dc.date.accessioned | 2021-04-13T07:50:24Z | - |
dc.date.available | 2021-04-13T07:50:24Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-03-23T10:47:57Z | - |
dc.identifier.citation | MOLECULES, 26 (4) (Art N° 935) | - |
dc.identifier.uri | http://hdl.handle.net/1942/33904 | - |
dc.description.abstract | Coccoloba cowellii Britton (Polygonaceae) is an endemic and critically endangered plant that only grows in Camaguey, a province of Cuba. In this study, a total of 13 compounds were identified in a methanolic leaf extract, employing a dereplication of the UHPLC-HRMS data by means of feature-based molecular networking (FBMN) analysis in the Global Natural Products Social Molecular Network (GNPS), together with the interpretation of the MS/MS data and comparison with the literature. The major constituents were glucuronides and glycosides of myricetin and quercetin, as well as epichatechin-3-O-gallate, catechin, epicatechin and gallic acid, all of them being reported for the first time in C. cowellii leaves. The leaf extract was also tested against various microorganisms, and it showed a strong antifungal effect against Candida albicans ATCC B59630 (azole-resistant) (IC50 2.1 mu g/mL) and Cryptococcus neoformans ATCC B66663 (IC50 4.1 mu g/mL) with no cytotoxicity (CC50 > 64.0 mu g/mL) on MRC-5 SV2 cells, determined by the resazurin assay. Additionally, the extract strongly inhibited COX-1 and COX-2 enzyme activity using a cell-free experiment in a dose-dependent manner, being significantly more active on COX-1 (IC50 4.9 mu g/mL) than on COX-2 (IC50 10.4 mu g/mL). The constituents identified as well as the pharmacological activities measured highlight the potential of C. cowellii leaves, increasing the interest in the implementation of conservation strategies for this species. | - |
dc.description.sponsorship | This research was funded by VLIR-IUC, grant number CU2019IUC030A105-77143, and VLIR-TEAM, grant number CU2017TEA433A102. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/) | - |
dc.subject.other | Coccoloba cowellii | - |
dc.subject.other | endemic plant | - |
dc.subject.other | UHPLC-ESI-QTOF-MS | - |
dc.subject.other | flavonoids | - |
dc.subject.other | antifungal | - |
dc.subject.other | antibacterial | - |
dc.subject.other | COX-1 | - |
dc.subject.other | 2 inhibition | - |
dc.title | Chemical and Pharmacological Potential of Coccoloba cowellii, an Endemic Endangered Plant from Cuba | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 4 | - |
dc.identifier.volume | 26 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Pieters, L (corresponding author), Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal NatuRA, Univ Pl 1, BE-2610 Antwerp, Belgium.; Cos, P (corresponding author), Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg LMPH, Univ Pl 1, BE-2610 Antwerp, Belgium. | - |
dc.description.notes | daniel.mendez@reduc.edu.cu; jcea@uo.edu.cu; kenn.foubert@uantwerpen.be; | - |
dc.description.notes | an.matheeussen@uantwerpen.be; anastasia.vanderauwera@uantwerpen.be; | - |
dc.description.notes | stefano.piazza@unimi.it; ann.cuypers@uhasselt.be; | - |
dc.description.notes | paul.cos@uantwerpen.be; luc.pieters@uantwerpen.be | - |
dc.description.other | Pieters, L (corresponding author), Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal NatuRA, Univ Pl 1, BE-2610 Antwerp, Belgium. Cos, P (corresponding author), Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg LMPH, Univ Pl 1, BE-2610 Antwerp, Belgium. daniel.mendez@reduc.edu.cu; jcea@uo.edu.cu; kenn.foubert@uantwerpen.be; an.matheeussen@uantwerpen.be; anastasia.vanderauwera@uantwerpen.be; stefano.piazza@unimi.it; ann.cuypers@uhasselt.be; paul.cos@uantwerpen.be; luc.pieters@uantwerpen.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 935 | - |
dc.identifier.doi | 10.3390/molecules26040935 | - |
dc.identifier.pmid | 33578815 | - |
dc.identifier.isi | WOS:000624188900001 | - |
dc.contributor.orcid | cos, paul/0000-0003-4361-8911; Cuypers, Ann/0000-0002-0171-0245; Piazza, | - |
dc.contributor.orcid | Stefano/0000-0002-2470-6038 | - |
dc.identifier.eissn | 1420-3049 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Mendez, Daniel] Univ Camaguey, Fac Sci Appl, Dept Chem, Carretera Circunvalac Km 5 1-2, Camaguey 74650, Cuba. | - |
local.description.affiliation | [Escalona-Arranz, Julio C.] Oriente Univ, Fac Nat & Exact Sci, Dept Pharm, Ave Patricio Lumumba S-N, Santiago De Cuba 90500, Cuba. | - |
local.description.affiliation | [Foubert, Kenn; Van der Auwera, Anastasia; Pieters, Luc] Univ Antwerp, Dept Pharmaceut Sci, Nat Prod & Food Res & Anal NatuRA, Univ Pl 1, BE-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Matheeussen, An; Cos, Paul] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg LMPH, Univ Pl 1, BE-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Piazza, Stefano] Univ Milan UNIMI, Dept Pharmacol & Biomol Sci, Lab Pharmacognosy, IT-20133 Milan, Italy. | - |
local.description.affiliation | [Cuypers, Ann] Hasselt Univ, Ctr Environm Sci, Campus Diepenbeek,Agoralaan Bldg D, BE-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.contributor | Mendez, Daniel | - |
item.contributor | Escalona-Arranz, Julio C. | - |
item.contributor | Foubert, Kenn | - |
item.contributor | Matheeussen, An | - |
item.contributor | Van der Auwera, Anastasia | - |
item.contributor | Piazza, Stefano | - |
item.contributor | CUYPERS, Ann | - |
item.contributor | Cos, Paul | - |
item.contributor | Pieters, Luc | - |
item.accessRights | Open Access | - |
item.fullcitation | Mendez, Daniel; Escalona-Arranz, Julio C.; Foubert, Kenn; Matheeussen, An; Van der Auwera, Anastasia; Piazza, Stefano; CUYPERS, Ann; Cos, Paul & Pieters, Luc (2021) Chemical and Pharmacological Potential of Coccoloba cowellii, an Endemic Endangered Plant from Cuba. In: MOLECULES, 26 (4) (Art N° 935). | - |
item.validation | ecoom 2022 | - |
crisitem.journal.eissn | 1420-3049 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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molecules-26-00935-v2.pdf | Published version | 804.08 kB | Adobe PDF | View/Open |
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