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http://hdl.handle.net/1942/33979
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DC Field | Value | Language |
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dc.contributor.author | HOLLAND, Amy | - |
dc.contributor.author | Bon-Frauches, Ana Carina | - |
dc.contributor.author | Keszthelyi, Daniel | - |
dc.contributor.author | Melotte, Veerle | - |
dc.contributor.author | BOESMANS, Werend | - |
dc.date.accessioned | 2021-04-26T08:45:11Z | - |
dc.date.available | 2021-04-26T08:45:11Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-04-13T11:58:00Z | - |
dc.identifier.citation | CELLULAR AND MOLECULAR LIFE SCIENCES, 78(10), p. 4713-4733 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | http://hdl.handle.net/1942/33979 | - |
dc.description.abstract | A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate digestive processes and gastrointestinal homeostasis. Because ENS components are in charge of the autonomous regulation of gut function, it is inevitable that their dysfunction is central to the pathophysiology and symptom generation of gastrointestinal disease. While for neurodevelopmental disorders such as Hirschsprung, ENS pathogenesis appears to be clear-cut, the role for impaired ENS activity in the etiology of other gastrointestinal disorders is less established and is often deemed secondary to other insults like intestinal inflammation. However, mounting experimental evidence in recent years indicates that gastrointestinal homeostasis hinges on multifaceted connections between the ENS, and other cellular networks such as the intestinal epithelium, the immune system, and the intestinal microbiome. Derangement of these interactions could underlie gastrointestinal disease onset and elicit variable degrees of abnormal gut function, pinpointing, perhaps unexpectedly, the ENS as a diligent participant in idiopathic but also in inflammatory and cancerous diseases of the gut. In this review, we discuss the latest evidence on the role of the ENS in the pathogenesis of enteric neuropathies, disorders of gut-brain interaction, inflammatory bowel diseases, and colorectal cancer. | - |
dc.description.sponsorship | This work is supported by grants from the Research Foundation Flanders (FWO: G036320N) and the Dutch Research Council (NWO VIDI: 016.196.367). | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | - |
dc.subject.other | Neural crest | - |
dc.subject.other | Irritable bowel syndrome | - |
dc.subject.other | Inflammatory bowel disease | - |
dc.subject.other | Hirschsprung disease | - |
dc.subject.other | Microbiota | - |
dc.title | The enteric nervous system in gastrointestinal disease etiology | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4733 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 4713 | - |
dc.identifier.volume | 78 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Boesmans, W (corresponding author), Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Pathol, Maastricht, Netherlands.; Boesmans, W (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Diepenbeek, Belgium. | - |
dc.description.notes | werend.boesmans@uhasselt.be | - |
dc.description.other | Boesmans, W (corresponding author), Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Pathol, Maastricht, Netherlands. Hasselt Univ, Biomed Res Inst BIOMED, Diepenbeek, Belgium. werend.boesmans@uhasselt.be | - |
local.publisher.place | PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1007/s00018-021-03812-y | - |
dc.identifier.isi | 000633294800001 | - |
dc.contributor.orcid | Holland, Amy/0000-0002-3150-4477; Boesmans, Werend/0000-0002-2426-0451 | - |
dc.identifier.eissn | 1420-9071 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Holland, Amy Marie; Bon-Frauches, Ana Carina; Melotte, Veerle; Boesmans, Werend] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Pathol, Maastricht, Netherlands. | - |
local.description.affiliation | [Holland, Amy Marie; Boesmans, Werend] Hasselt Univ, Biomed Res Inst BIOMED, Diepenbeek, Belgium. | - |
local.description.affiliation | [Keszthelyi, Daniel] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Internal Med,Div Gastroenterol Hepatol, Maastricht, Netherlands. | - |
local.description.affiliation | [Melotte, Veerle] Erasmus MC Univ Med Ctr, Dept Clin Genet, Rotterdam, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | HOLLAND, Amy; Bon-Frauches, Ana Carina; Keszthelyi, Daniel; Melotte, Veerle & BOESMANS, Werend (2021) The enteric nervous system in gastrointestinal disease etiology. In: CELLULAR AND MOLECULAR LIFE SCIENCES, 78(10), p. 4713-4733. | - |
item.accessRights | Open Access | - |
item.contributor | HOLLAND, Amy | - |
item.contributor | Bon-Frauches, Ana Carina | - |
item.contributor | Keszthelyi, Daniel | - |
item.contributor | Melotte, Veerle | - |
item.contributor | BOESMANS, Werend | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 1420-682X | - |
crisitem.journal.eissn | 1420-9071 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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s00018-021-03812-y.pdf | Published version | 1.12 MB | Adobe PDF | View/Open |
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