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Title: | Peritoneal Metastases From Colorectal Cancer: Defining and Addressing the Challenges | Authors: | Kranenburg, Onno VAN DER SPEETEN, Kurt de Hingh, Ignace |
Issue Date: | 2021 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in Oncology, 11 (Art N° 650098) | Abstract: | The presence of peritoneal metastases (PM) in patients with colorectal cancer (CRC) is associated with an extremely poor prognosis. The diagnosis of PM is challenging, resulting in an underestimation of their true incidence. While surgery can be curative in a small percentage of patients, effective treatment for non-operable PM is lacking, and clinical and pre-clinical studies are relatively sparse. Here we have defined the major clinical challenges in the areas of risk assessment, detection, and treatment. Recent developments in the field include the application of organoid technology, which has generated highly relevant pre-clinical PM models, the application of diffusion-weighted MRI, which has greatly improved PM detection, and the design of small clinical proof-of-concept studies, which allows the efficient testing of new treatment strategies. Together, these developments set the stage for starting to address the clinical challenges. To help structure these efforts, a translational research framework is presented, in which clinical trial design is based on the insight gained from direct tissue analyses and pre-clinical (organoid) models derived from CRC patients with PM. This feed-forward approach, in which a thorough understanding of the disease drives innovation in its clinical management, has the potential to improve outcome in the years to come. | Notes: | Kranenburg, O (corresponding author), Univ Med Ctr Utrecht, Dept Surg Oncol, Utrecht, Netherlands.; Kranenburg, O (corresponding author), Univ Utrecht, Utrecht Platform Organoid Technol, Utrecht, Netherlands. o.kranenburg@umcutrecht.nl |
Other: | Kranenburg, O (corresponding author), Univ Med Ctr Utrecht, Dept Surg Oncol, Utrecht, Netherlands ; Univ Utrecht, Utrecht Platform Organoid Technol, Utrecht, Netherlands. o.kranenburg@umcutrecht.nl | Keywords: | colorectal;colorectal;CMS4;CMS4;peritoneal;peritoneal;imaging;imaging;organoid;organoid | Document URI: | http://hdl.handle.net/1942/33981 | ISSN: | 2234-943X | e-ISSN: | 2234-943X | DOI: | 10.3389/fonc.2021.650098 | ISI #: | WOS:000634717100001 | Rights: | 2021 Kranenburg, Speeten and Hingh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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