Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/33983
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bastiaensen, Michiel | - |
dc.contributor.author | Gys, Celine | - |
dc.contributor.author | Colles, Ann | - |
dc.contributor.author | Malarvannan, Govindan | - |
dc.contributor.author | Verheyen, Veerle | - |
dc.contributor.author | Koppen, Gudrun | - |
dc.contributor.author | Govarts, Eva | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Morrens, Bert | - |
dc.contributor.author | Franken, Carmen | - |
dc.contributor.author | Den Hond, Elly | - |
dc.contributor.author | Schoeters, Greet | - |
dc.contributor.author | Covaci, Adrian | - |
dc.date.accessioned | 2021-04-26T09:53:14Z | - |
dc.date.available | 2021-04-26T09:53:14Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-04-13T12:11:53Z | - |
dc.identifier.citation | ENVIRONMENTAL POLLUTION, 276 (Art N° 116724) | - |
dc.identifier.issn | 02697491 | - |
dc.identifier.uri | http://hdl.handle.net/1942/33983 | - |
dc.description.abstract | Restrictions on the use of legacy phthalate esters (PEs) as plasticizer chemicals in several consumer products has led to the increased use of alternative plasticizers (APs), such as di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) and di-(2-ethylhexyl) terephthalate (DEHTP). In the fourth cycle of the Flemish Environment and Health Study (FLEHS IV, 2016-2020), we monitored exposure to seven PEs (diethyl phthalate (DEP), di-(2-ethylhexyl) phthalate (DEHP), di-isobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP, di-isononyl phthalate (DINP), and di-isodecyl phthalate (DIDP))and three APs (DINCH, DEHTP, and di-(2-ethylhexyl) adipate (DEHA)) by measuring multiple biomarkers in urine of 416 adolescents from Flanders, Belgium (14-15 years old). The reference values show that exposure to PEs is still widespread, although levels of several PE metabolites (e.g., sum of DEHP metabolites, mono-normal-butyl phthalate (MnBP) and mono-benzyl phthalate (MBzP)) have decreased significantly compared to previous human biomonitoring cycles (2003-2018). On the other hand, metabolites of DINCH and DEHTP were detected in practically every participant. Concentrations of AP exposure biomarkers in urine were generally lower than PE metabolites, but calculations of estimated daily intakes (EDIs) showed that exposure to DINCH and DEHTP can be considerable. However, preliminary risk assessment showed that none of the EDI or urinary exposure levels of APs exceeded the available health-based guidance values, while a very low number of participants had levels of MiBP and MnBP exceeding the HBM value. Several significant determinants of exposure could be identified from multiple regression models: the presence of building materials containing PVC, ventilation habits, socioeconomic status and season were all associated with PE and AP biomarker levels. Cumulatively, the results of FLEHS IV show that adolescents in Flanders, Belgium, are exposed to a wide range of plasticizer chemicals. Close monitoring over the last decade showed that the exposure levels of restricted PEs have decreased, while newer APs are now frequently detected in humans. (C) 2021 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | We are highly indebted to all adolescents and their families who participated in FLEHS IV. Without their effort this study would not have been possible. We also thank A. Klimowska for her assistance during the analyses of the samples. This paper is based on research conducted within the framework of the Flemish Center of Expertise on Environment and Health (FLEHS 2016-2020), funded by the Government of Flanders, Department of Environment & Spatial Development. The views expressed herein are those of the author(s) and are not necessarily endorsed by the government of Flanders. The Flemish Environment and Health Study was commissioned, financed and steered by the Ministry of the Flemish Community, including the partial funding of the Ph.D. of Michiel Bastiaensen. Celine Gys acknowledges the funding of a PhD fellowship from Research Foundation Flanders (project G0E5216 N). The partial financial funding of the European Human Biomonitoring project (HBM4EU) is gratefully acknowledged. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | 2021 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Alternative plasticizers | - |
dc.subject.other | PEs | - |
dc.subject.other | Human biomonitoring | - |
dc.subject.other | Estimated daily intake | - |
dc.subject.other | Exposure biomarkers | - |
dc.subject.other | Flanders | - |
dc.title | Biomarkers of phthalates and alternative plasticizers in the Flemish Environment and Health Study (FLEHS IV): Time trends and exposure assessment | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 276 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Covaci, A (corresponding author), Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
dc.description.notes | adrian.covaci@uantwerpen.be | - |
dc.description.other | Covaci, A (corresponding author), Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. adrian.covaci@uantwerpen.be | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 116724 | - |
dc.identifier.doi | 10.1016/j.envpol.2021.116724 | - |
dc.identifier.pmid | 33631684 | - |
dc.identifier.isi | WOS:000630774100056 | - |
dc.contributor.orcid | Verheyen, Veerle/0000-0002-5262-5665 | - |
dc.identifier.eissn | 1873-6424 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Bastiaensen, Michiel; Gys, Celine; Malarvannan, Govindan; Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Colles, Ann; Verheyen, Veerle; Koppen, Gudrun; Govarts, Eva; Schoeters, Greet] Flemish Inst Technol Res VITO, VITO Hlth, Boeretang 200, B-2400 Mol, Belgium. | - |
local.description.affiliation | [Verheyen, Veerle; Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Bruckers, Liesbeth] Hasselt Univ, Data Sci Inst, BioStat, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Morrens, Bert] Univ Antwerp, Fac Social Sci, Sint Jacobstr 2, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Franken, Carmen; Den Hond, Elly] Prov Inst Hyg, Kronenburgstr 45, B-2000 Antwerp, Belgium. | - |
local.uhasselt.international | no | - |
item.contributor | Bastiaensen, Michiel | - |
item.contributor | Gys, Celine | - |
item.contributor | Colles, Ann | - |
item.contributor | Malarvannan, Govindan | - |
item.contributor | Verheyen, Veerle | - |
item.contributor | Koppen, Gudrun | - |
item.contributor | Govarts, Eva | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Morrens, Bert | - |
item.contributor | Franken, Carmen | - |
item.contributor | Den Hond, Elly | - |
item.contributor | Schoeters, Greet | - |
item.contributor | Covaci, Adrian | - |
item.validation | ecoom 2022 | - |
item.fullcitation | Bastiaensen, Michiel; Gys, Celine; Colles, Ann; Malarvannan, Govindan; Verheyen, Veerle; Koppen, Gudrun; Govarts, Eva; BRUCKERS, Liesbeth; Morrens, Bert; Franken, Carmen; Den Hond, Elly; Schoeters, Greet & Covaci, Adrian (2021) Biomarkers of phthalates and alternative plasticizers in the Flemish Environment and Health Study (FLEHS IV): Time trends and exposure assessment. In: ENVIRONMENTAL POLLUTION, 276 (Art N° 116724). | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0269-7491 | - |
crisitem.journal.eissn | 1873-6424 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ENVPOL-D-20-02772_clean.pdf | Peer-reviewed author version | 585.11 kB | Adobe PDF | View/Open |
1-s2.0-S0269749121003043-main.pdf Restricted Access | Published version | 508.89 kB | Adobe PDF | View/Open Request a copy |
WEB OF SCIENCETM
Citations
21
checked on Apr 24, 2024
Page view(s)
46
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.