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http://hdl.handle.net/1942/33992
Title: | Unravelling Ipsilateral Interactions Between Left Dorsal Premotor and Primary Motor Cortex: A Proof of Concept Study | Authors: | VAN HOORNWEDER, Sybren Debeuf, Ruben VERSTRAELEN, Stefanie MEESEN, Raf CUYPERS, Koen |
Issue Date: | 2021 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | NEUROSCIENCE, 466, p. 36-46 | Abstract: | Few studies have identified the intrahemispheric functional connectivity between the ipsilateral dorsal premotor cortex (PMd) and the primary motor hand area (M1(hand)) due to technical limitations. In this proof-ofconcept study, a novel neuronavigated dsTMS set-up was employed, combining stimulation over left PMd and left M1(hand) using the edge of a butterfly coil and a small cooled-coil. This arrangement was warranted because coil (over)heating and inter coil distance are limiting factors when investigating connectivity between stimulation targets in close proximity and over a longer duration. The proposed set-up was designed to deal with these limitations. Specifically, the effect of four dual-site transcranial magnetic stimulation (dsTMS) protocols on twentyeight right-handed participants (12 males) was evaluated. These protocols differed in stimulus order, interstimulus interval and current direction induced in PMd. A structural scan with electric (E-)field modeling was obtained from seven participants prior to dsTMS, demonstrating that PMd and M1(hand) were effectively stimulated. Results indicate that one protocol, in which a latero-medial current was induced in PMd 2.8 ms prior to stimulation over M1(hand), induced a sex-mediated effect. In males, significant inhibition of motor-evoked potentials was identified, whereas females demonstrated a facilitatory effect that did not survive correction for multiple comparisons. E-field simulations revealed that the E-field induced by the coil targeting PMd was maximal in PMd, with weaker E-field strengths extending to regions beyond PMd. Summarizing, the current dsTMS set-up enabled stimulating at an inter-target distance of 35 mm without any indications of coil-overheating. (C) 2021 IBRO. Published by Elsevier Ltd. All rights reserved. | Keywords: | transcranial magnetic stimulation;dorsal premotor cortex;primary motor cortex;functional connectivity;brain modelling | Document URI: | http://hdl.handle.net/1942/33992 | ISSN: | 0306-4522 | e-ISSN: | 1873-7544 | DOI: | 10.1016/j.neuroscience.2021.04.033 | ISI #: | 000661401900004 | Rights: | 2021 IBRO. Published by Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.0-S0306452221002396-main.pdf Restricted Access | Published version | 2.35 MB | Adobe PDF | View/Open Request a copy |
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