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http://hdl.handle.net/1942/33995
Title: | Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy | Authors: | Vasconcelos, Bruno Bird, Matthew STANCU, Ilie Cosmin TERWEL, Dick DEWACHTER, Ilse |
Issue Date: | 2017 | Source: | Baekelandt, Veerle; Lobbestael, Evy (Ed.). Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies, p. 115 -156 | Abstract: | Animal models recapitulate characteristic pathological features of Alzheimer’s disease and related tauopathies, in addition to several phenotypic traits reminiscent of the disease. These animal models have been used as a central tool in the identification of therapeutic targets and their preclinical validation. A major focus has been on therapies targeting amyloid-β (Aβ). However, clinical trials aiming at Aβ have led to the general view that once the disease process has started, multitargeted combined therapies are required for disease-modifying therapies, including downstream targets in the amyloid cascade. These include not only tau as a crucial executor of the pathogenesis, but also mechanisms involved in spreading of tau-pathology and in Aβ-induced tau-pathology. In this work, we review the use of preclinical models for identification of targets for disease-modifying therapies. We thereby focus on the initial validation of targets currently tested in clinical trials, their constraints and subsequent fine-tuning, and on new venues for future therapies currently under study in preclinical models. | Keywords: | Alzheimer’s disease;amyloid-β;animal models;tau;disease-modifying therapies | Document URI: | http://hdl.handle.net/1942/33995 | ISBN: | 9780128051207 | DOI: | 10.1016/b978-0-12-805120-7.00006-3 | Category: | B2 | Type: | Book Section |
Appears in Collections: | Research publications |
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3-s2.0-B9780128051207000063-main.pdf Restricted Access | Published version | 2.92 MB | Adobe PDF | View/Open Request a copy |
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