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http://hdl.handle.net/1942/34080
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Nikita | - |
dc.contributor.author | SCHEPERS, Melissa | - |
dc.contributor.author | Zhan, Na | - |
dc.contributor.author | Leijten, Frank | - |
dc.contributor.author | Voortman, Gardi | - |
dc.contributor.author | TIANE, Assia | - |
dc.contributor.author | ROMBAUT, Ben | - |
dc.contributor.author | POISQUET, Janne | - |
dc.contributor.author | van de Sande, Nienke | - |
dc.contributor.author | Kerksiek, Anja | - |
dc.contributor.author | Kuipers, Folkert | - |
dc.contributor.author | Jonker, Johan W. | - |
dc.contributor.author | Liu, Hongbing | - |
dc.contributor.author | Lütjohann, Dieter | - |
dc.contributor.author | VANMIERLO, Tim | - |
dc.contributor.author | Mulder, Monique T. | - |
dc.date.accessioned | 2021-05-26T13:20:14Z | - |
dc.date.available | 2021-05-26T13:20:14Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-05-17T14:02:47Z | - |
dc.identifier.citation | Marine Drugs, 19 (4) (Art N° 190) | - |
dc.identifier.uri | http://hdl.handle.net/1942/34080 | - |
dc.description.abstract | We recently found that dietary supplementation with the seaweed Sargassum fusiforme, containing the preferential LXR beta-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-beta (A beta) deposition in an Alzheimer's disease (AD) mouse model without inducing hepatic steatosis. Here, we examined the effects of 24(S)-saringosterol as a food additive on cognition and neuropathology in AD mice. Six-month-old male APPswePS1 Delta E9 mice and wildtype C57BL/6J littermates received 24(S)-saringosterol (0.5 mg/25 g body weight/day) (APPswePS1 Delta E9 n = 20; C57BL/6J n = 19) or vehicle (APPswePS1 Delta E9 n = 17; C57BL/6J n = 19) for 10 weeks. Cognition was assessed using object recognition and object location tasks. Sterols were analyzed by gas chromatography/mass spectrometry, A beta and inflammatory markers by immunohistochemistry, and gene expression by quantitative real-time PCR. Hepatic lipids were quantified after Oil-Red-O staining. Administration of 24(S)-saringosterol prevented cognitive decline in APPswePS1 Delta E9 mice without affecting the A beta plaque load. Moreover, 24(S)-saringosterol prevented the increase in the inflammatory marker Iba1 in the cortex of APPswePS1 Delta E9 mice (p < 0.001). Furthermore, 24(S)-saringosterol did not affect the expression of lipid metabolism-related LXR-response genes in the hippocampus nor the hepatic neutral lipid content. Thus, administration of 24(S)-saringosterol prevented cognitive decline in APPswePS1 Delta E9 mice independent of effects on A beta load and without adverse effects on liver fat content. The anti-inflammatory effects of 24(S)-saringosterol may contribute to the prevention of cognitive decline. | - |
dc.description.sponsorship | Funding: This research was funded by the Alzheimer Nederland and Alzheimer Forschung Initiative (#15048 and #WE.03-2018-06 AN), and no APC was charged. Acknowledgments: We thank P. Martinez-Martinez and M.R. Losen (School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands) for providing the Aβ antibody (clone 3D6). | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | Alzheimer’ | - |
dc.subject.other | s disease | - |
dc.subject.other | seaweed | - |
dc.subject.other | Sargassum fusiforme | - |
dc.subject.other | phytosterols | - |
dc.subject.other | cholesterol metabolism | - |
dc.title | 24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 4 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 190 | - |
dc.identifier.doi | 10.3390/md19040190 | - |
dc.identifier.isi | WOS:000643197300001 | - |
dc.identifier.eissn | 1660-3397 | - |
local.provider.type | Web of Science | - |
local.uhasselt.uhpub | no | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | MARTENS, Nikita | - |
item.contributor | SCHEPERS, Melissa | - |
item.contributor | Zhan, Na | - |
item.contributor | Leijten, Frank | - |
item.contributor | Voortman, Gardi | - |
item.contributor | TIANE, Assia | - |
item.contributor | ROMBAUT, Ben | - |
item.contributor | POISQUET, Janne | - |
item.contributor | van de Sande, Nienke | - |
item.contributor | Kerksiek, Anja | - |
item.contributor | Kuipers, Folkert | - |
item.contributor | Jonker, Johan W. | - |
item.contributor | Liu, Hongbing | - |
item.contributor | Lütjohann, Dieter | - |
item.contributor | VANMIERLO, Tim | - |
item.contributor | Mulder, Monique T. | - |
item.fullcitation | MARTENS, Nikita; SCHEPERS, Melissa; Zhan, Na; Leijten, Frank; Voortman, Gardi; TIANE, Assia; ROMBAUT, Ben; POISQUET, Janne; van de Sande, Nienke; Kerksiek, Anja; Kuipers, Folkert; Jonker, Johan W.; Liu, Hongbing; Lütjohann, Dieter; VANMIERLO, Tim & Mulder, Monique T. (2021) 24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease. In: Marine Drugs, 19 (4) (Art N° 190). | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 1660-3397 | - |
crisitem.journal.eissn | 1660-3397 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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marinedrugs-19-00190-v2.pdf | Published version | 2.49 MB | Adobe PDF | View/Open |
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