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http://hdl.handle.net/1942/34085
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DC Field | Value | Language |
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dc.contributor.author | De Neubourg, Diane | - |
dc.contributor.author | BOGAERTS, Kris | - |
dc.contributor.author | Anagnostou, Elisabeth | - |
dc.contributor.author | Autin, Candice | - |
dc.contributor.author | Blockeel, Christophe | - |
dc.contributor.author | Coetsier, Tom | - |
dc.contributor.author | Delbaere, Anne | - |
dc.contributor.author | Gillain, Nicolas | - |
dc.contributor.author | Vandekerckhove, Frank | - |
dc.contributor.author | Wyns, Christine | - |
dc.date.accessioned | 2021-05-26T13:55:04Z | - |
dc.date.available | 2021-05-26T13:55:04Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-05-25T12:35:01Z | - |
dc.identifier.citation | REPRODUCTIVE BIOMEDICINE ONLINE, 42 (4) , p. 717 -724 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34085 | - |
dc.description.abstract | Research question: How do cumulative live birth rates (CLBR), cumulative multiple live birth rates (CMLBR) and dropout rates over six IVF and intracytoplasmic sperm injection (ICSI) cycles change over time? Design: Prospective longitudinal cohort (n = 16,073 patients; 48,946 cycles) starting a first fresh assisted reproductive technology cycle between 1 January 2014 and 31 December 2016, with follow-up until 31 December 2017 Outcomes between the periods 2014-2017 and 2009-2012 were compared. Results: Conservative estimates of CLBR after six complete cycles were significantly higher in women younger than 35 years after every cycle: one to three, adjusted P-value [p adj] < 0.0001; four, p = 0.01; five, p adj = 0.03; six, p adj = 0.04) and after the first cycle in women aged 35-37 years (p adj = 0.04) in 2014-2017 versus 2009-2012. For an optimal estimate, the CLBR was significantly higher after the first three cycles in women younger than 35 years (all p adj < 0.0001) and after the first cycle in women aged 35-37 years (p adj = 0.04). The CMLBR rate decreased from 5.1% 0.19 (SE) to 4.1% 0.16 for the conservative estimate and from 8.6% 0.37 (SE) to 6.7% 0.30 for the optimal estimate after six complete cycles for the whole cohort. Dropout rates of complete cycles were 26.5% 29.4%, 33.4%, 38.9% and 473% after the first to fifth cycle, respectively. Compared with 2009-2012, the dropout rate in the current period was significantly higher for the first (P < 0.0001) and second (P = 0.0124) cycle. Conclusion: Over six complete IVF/ICSI cycles, CLBR and dropout rates increased and multiple live birth rates decreased when 2014-2017 was compared with 2009-2012. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.rights | © 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Cumulative live birth rate | - |
dc.subject.other | Cumulative multiple live birth rate | - |
dc.subject.other | Discontinuation | - |
dc.subject.other | Drop-out rate | - |
dc.subject.other | IVF/ICSI | - |
dc.title | Evolution of cumulative live birth and dropout rates over six complete IVF/ICSI cycles: a large prospective cohort study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 724 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 717 | - |
dc.identifier.volume | 42 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | De Neubourg, D (corresponding author), Univ Antwerp, Univ Antwerp Hosp, Ctr Reprod Med, Fac Med & Hlth Sci, Wilrijkstr 10, B-2650 Edegem, Belgium. | - |
dc.description.notes | diane.deneubourg@uza.be | - |
dc.description.other | De Neubourg, D (corresponding author), Univ Antwerp, Univ Antwerp Hosp, Ctr Reprod Med, Fac Med & Hlth Sci, Wilrijkstr 10, B-2650 Edegem, Belgium. diane.deneubourg@uza.be | - |
local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.rbmo.2021.01.005 | - |
dc.identifier.isi | WOS:000638134200006 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [De Neubourg, Diane] Univ Antwerp, Univ Antwerp Hosp, Ctr Reprod Med, Fac Med & Hlth Sci, Wilrijkstr 10, B-2650 Edegem, Belgium. | - |
local.description.affiliation | [Bogaerts, Kris] Katholieke Univ Leuven, I BioStat, Leuven, Belgium. | - |
local.description.affiliation | [Bogaerts, Kris] Univ Hasselt, Hasselt, Belgium. | - |
local.description.affiliation | [Anagnostou, Elisabeth] Ctr Procreat Medicalement Assistee, Tournai, Belgium. | - |
local.description.affiliation | [Autin, Candice] Ctr Procreat Medicalement Assistee, Brussels, Belgium. | - |
local.description.affiliation | [Blockeel, Christophe] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Reprod Med, Brussels, Belgium. | - |
local.description.affiliation | [Coetsier, Tom] AZ St Lucas, Fertil Ctr, Ghent, Belgium. | - |
local.description.affiliation | [Delbaere, Anne] Univ Libre Bruxelles, Serv Gynecol Obstet, Clin Fertilite, Hop Erasme, Brussels, Belgium. | - |
local.description.affiliation | [Gillain, Nicolas] Univ Liege, Nutr Environm & Hlth, Liege, Belgium. | - |
local.description.affiliation | [Vandekerckhove, Frank] UZ Gent, Afdeling Reprod Geneeskunde, Ghent, Belgium. | - |
local.description.affiliation | [Wyns, Christine] Catholic Univ Louvain, Clin Univ St Luc, Dept Gynaecol Androl, Brussels, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.contributor | De Neubourg, Diane | - |
item.contributor | BOGAERTS, Kris | - |
item.contributor | Anagnostou, Elisabeth | - |
item.contributor | Autin, Candice | - |
item.contributor | Blockeel, Christophe | - |
item.contributor | Coetsier, Tom | - |
item.contributor | Delbaere, Anne | - |
item.contributor | Gillain, Nicolas | - |
item.contributor | Vandekerckhove, Frank | - |
item.contributor | Wyns, Christine | - |
item.accessRights | Open Access | - |
item.fullcitation | De Neubourg, Diane; BOGAERTS, Kris; Anagnostou, Elisabeth; Autin, Candice; Blockeel, Christophe; Coetsier, Tom; Delbaere, Anne; Gillain, Nicolas; Vandekerckhove, Frank & Wyns, Christine (2021) Evolution of cumulative live birth and dropout rates over six complete IVF/ICSI cycles: a large prospective cohort study. In: REPRODUCTIVE BIOMEDICINE ONLINE, 42 (4) , p. 717 -724. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1472-6483 | - |
crisitem.journal.eissn | 1472-6491 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
CLBR & Drop-out rates 20201117.pdf | Peer-reviewed author version | 1.55 MB | Adobe PDF | View/Open |
RBMO.pdf Restricted Access | Published version | 1.31 MB | Adobe PDF | View/Open Request a copy |
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