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Title: | The prevalence and related factors of fatigue in patients with COPD: a systematic review | Authors: | Ebadi, Zjala Goërtz, Yvonne VAN HERCK, Maarten Janssen, Daisy SPRUIT, Martijn A. BURTIN, Chris Thong, Melissa Muris, Jean Otker, Jacqueline Looijmans, Milou Vlasblom, Christel Bastiaansen, Joëlle Prins, Judith Wouters, Emiel Vercoulen, Jan Peters, Jeannette |
Issue Date: | 2021 | Publisher: | European Respiratory Society | Source: | European Respiratory Review, 30 (160) (Art N° 200298) | Abstract: | Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD. Methods Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings "COPD" and "Fatigue". Studies were reviewed in accordance with PRISMA guidelines. Results 196 studies were evaluated. The prevalence of fatigue ranged from 17-95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue. Conclusions Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD. | Document URI: | http://hdl.handle.net/1942/34101 | ISSN: | 0905-9180 | e-ISSN: | 1600-0617 | DOI: | 10.1183/16000617.0298-2020 | ISI #: | WOS:000640215500004 | Rights: | This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Ebadi Goërtz et al 2021 - ERR - SR fatigue and related factors in COPD.pdf | Published version | 709.48 kB | Adobe PDF | View/Open |
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