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Title: | Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders | Authors: | SPAAS, Jan VAN VEGGEL, Lieve SCHEPERS, Melissa TIANE, Assia VAN HORSSEN, Jack WILSON, David Moya, Pablo R. PICCART, Elisabeth HELLINGS, Niels OP 'T EIJNDE, Bert Derave, Wim Schreiber, Rudy VANMIERLO, Tim |
Issue Date: | 2021 | Publisher: | SPRINGER BASEL AG | Source: | Cellular and Molecular Life Sciences, 78 (10) , p. 4615-4637 | Abstract: | Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that occurs due to brain injury or inflammation-induced demyelination (remyelination) but are also pivotal in plastic processes such as learning and memory (adaptive myelination). OPC differentiation into mature myelinating oligodendrocytes is controlled by a complex transcriptional network and depends on high metabolic and mitochondrial demand. Mounting evidence shows that OPC dysfunction, culminating in the lack of OPC differentiation, mediates the progression of neurodegenerative disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. Importantly, neurodegeneration is characterised by oxidative and carbonyl stress, which may primarily affect OPC plasticity due to the high metabolic demand and a limited antioxidant capacity associated with this cell type. The underlying mechanisms of how oxidative/carbonyl stress disrupt OPC differentiation remain enigmatic and a focus of current research efforts. This review proposes a role for oxidative/carbonyl stress in interfering with the transcriptional and metabolic changes required for OPC differentiation. In particular, oligodendrocyte (epi)genetics, cellular defence and repair responses, mitochondrial signalling and respiration, and lipid metabolism represent key mechanisms how oxidative/carbonyl stress may hamper OPC differentiation in neurodegenerative disorders. Understanding how oxidative/carbonyl stress impacts OPC function may pave the way for future OPC-targeted treatment strategies in neurodegenerative disorders. | Notes: | Vanmierlo, T (corresponding author), Univ MS Ctr UMSC, Hasselt Pelt, Belgium.; Vanmierlo, T (corresponding author), Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, Hasselt, Belgium.; Vanmierlo, T (corresponding author), Maastricht Univ, European Grad Sch Neurosci, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol,Div Translat Neurosc, Maastricht, Netherlands. tim.vanmierlo@uhasselt.be |
Other: | Vanmierlo, T (corresponding author), Univ MS Ctr UMSC, Hasselt Pelt, Belgium ; Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, Hasselt, Belgium Maastricht Univ, European Grad Sch Neurosci, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol,Div Translat Neurosc, Maastricht, Netherlands. tim.vanmierlo@uhasselt.be | Keywords: | Oligodendrocyte precursor cell;Oxidative stress;Carbonyl stress;Neurodegeneration;Myelination | Document URI: | http://hdl.handle.net/1942/34178 | ISSN: | 1420-682X | e-ISSN: | 1420-9071 | DOI: | 10.1007/s00018-021-03802-0 | ISI #: | 000626819200001 | Rights: | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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