Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/34199
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | HEYENS, Leen | - |
dc.contributor.author | BUSSCHOTS, Dana | - |
dc.contributor.author | Koek, Ger H. | - |
dc.contributor.author | ROBAEYS, Geert | - |
dc.contributor.author | Francque, Sven | - |
dc.date.accessioned | 2021-06-02T10:31:35Z | - |
dc.date.available | 2021-06-02T10:31:35Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-06-01T13:34:38Z | - |
dc.identifier.citation | Frontiers in medicine (Lausanne), 8 (Art N° 615978) | - |
dc.identifier.uri | http://hdl.handle.net/1942/34199 | - |
dc.description.abstract | An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis to non-alcoholic steatohepatitis (NASH). NASH is a chronic state of liver inflammation that leads to the transformation of hepatic stellate cells to myofibroblasts. These cells produce extra-cellular matrix that results in liver fibrosis. In a normal situation, fibrogenesis is a wound healing process that preserves tissue integrity. However, sustained and progressive fibrosis can become pathogenic. This process takes many years and is often asymptomatic. Therefore, patients usually present themselves with end-stage liver disease e.g., liver cirrhosis, decompensated liver disease or even hepatocellular carcinoma. Fibrosis has also been identified as the most important predictor of prognosis in patients with NAFLD. Currently, only a minority of patients with liver fibrosis are identified to be at risk and hence referred for treatment. This is not only because the disease is largely asymptomatic, but also due to the fact that currently liver biopsy is still the golden standard for accurate detection of liver fibrosis. However, performing a liver biopsy harbors some risks and requires resources and expertise, hence is not applicable in every clinical setting and is unsuitable for screening. Consequently, different non-invasive diagnostic tools, mainly based on analysis of blood or other specimens or based on imaging have been developed or are in development. In this review, we will first give an overview of the pathogenic mechanisms of the evolution from isolated steatosis to fibrosis. This serves as the basis for the subsequent discussion of the current and future diagnostic biomarkers and anti-fibrotic drugs. | - |
dc.description.sponsorship | The Ph.D. authors of this paper are part of the Limburg Clinical Research Center (LCRC), supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | 2021 Heyens, Busschots, Koek, Robaeys and Francque. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | NAFLD | - |
dc.subject.other | liver fibrosis | - |
dc.subject.other | liver biopsy | - |
dc.subject.other | non-invasive assessment | - |
dc.subject.other | liver stiffness | - |
dc.title | Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 8 | - |
local.format.pages | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Francque, S (corresponding author), Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Antwerp, Belgium.; Francque, S (corresponding author), Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Med & Paediat, Antwerp, Belgium. | - |
dc.description.notes | sven.francque@uza.be | - |
dc.description.other | Francque, S (corresponding author), Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Antwerp, Belgium ; Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Med & Paediat, Antwerp, Belgium. sven.francque@uza.be | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 615978 | - |
dc.identifier.doi | 10.3389/fmed.2021.615978 | - |
dc.identifier.isi | WOS:000644699200001 | - |
dc.identifier.eissn | 2296-858X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Heyens, Leen J. M.; Busschots, Dana; Robaeys, Geert] Hasselt Univ, Fac Hlth & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [Heyens, Leen J. M.; Busschots, Dana; Koek, Ger H.] Maastricht Univ, Sch Nutr & Translat Res Metab, NUTRIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Heyens, Leen J. M.; Robaeys, Geert] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. | - |
local.description.affiliation | [Koek, Ger H.] Maastricht Univ, Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Maastricht, Netherlands. | - |
local.description.affiliation | [Robaeys, Geert] Univ Hosp Katholieke Univ KU Leuven, Dept Gastroenterol & Hepatol, Leuven, Belgium. | - |
local.description.affiliation | [Francque, Sven] Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Antwerp, Belgium. | - |
local.description.affiliation | [Francque, Sven] Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Med & Paediat, Antwerp, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | HEYENS, Leen; BUSSCHOTS, Dana; Koek, Ger H.; ROBAEYS, Geert & Francque, Sven (2021) Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment. In: Frontiers in medicine (Lausanne), 8 (Art N° 615978). | - |
item.accessRights | Open Access | - |
item.contributor | HEYENS, Leen | - |
item.contributor | BUSSCHOTS, Dana | - |
item.contributor | Koek, Ger H. | - |
item.contributor | ROBAEYS, Geert | - |
item.contributor | Francque, Sven | - |
crisitem.journal.issn | 2296-858X | - |
crisitem.journal.eissn | 2296-858X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fmed-08-615978.pdf | Published version | 1.86 MB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
98
checked on Jul 11, 2024
Page view(s)
22
checked on May 20, 2022
Download(s)
8
checked on May 20, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.